Article
Chemistry, Multidisciplinary
Durairaj Siva, Subramanian Abinaya, Durairaj Rajesh, Govindaraju Archunan, Parasuraman Padmanabhan, Balazs Gulyas, Shanmugam Achiraman
Summary: This study investigates the possible mechanism of doxorubicin-mediated cardiotoxicity and explores the use of chitosan nanoparticles conjugated with doxorubicin and supplemented with propionic acid to reduce the cardiotoxicity. The results show that DCNPs and propionic acid have a protective effect against doxorubicin-induced cardiotoxicity.
Article
Biochemistry & Molecular Biology
Zhendong Ding, Mengmiao Mo, Kai Zhang, Yongguang Bi, Fansheng Kong
Summary: In this study, PC-CS-NPs were successfully prepared and demonstrated sustainable release of proanthocyanidins, excellent scavenging ability of free radicals, and inhibitory effects on bacterial growth. The findings suggest that the use of chitosan nanoparticles can enhance the bioactivity of proanthocyanidins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Samira Heidari, Mehdi Akhlaghi, Mahdi Sadeghi, Amin Mokhtari Kheirabadi, Davood Beiki, Alireza Emami Ardekani, Amir Rouhollah, Parya Saeidzadeh, Rouhollah Soleyman
Summary: Selective delivery of high dosage of doxorubicin to the lung was achieved through the use of hollow microcapsules. The microcapsules were non-toxic, compatible with red blood cells, and did not affect blood coagulation time. PET-CT images showed that the majority of the loaded drug was delivered to the lungs and sustainably released.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Rahaf M. Ahmad, Yaser E. Greish, Hesham F. El-Maghraby, Loay Lubbad, Yahia Makableh, Fayez T. Hammad
Summary: Chitosan-alginate nanoparticles loaded with Nerolidol were successfully fabricated and characterized, showing potential encapsulation and delivery using an in vitro model. Various techniques including Fourier transform infrared spectroscopy, scanning and transmission electron microscopy were used for nanoparticle characterization.
Article
Biochemistry & Molecular Biology
Ezgi Kizilkonca, Emrah Torlak, F. Bedia Erim
Summary: The effects of cerium oxide nanoparticles on chitosan-based films were investigated, showing enhanced antibacterial activity. These composite films, based on chitosan, exhibit flexibility, antibacterial efficacy, and good mechanical strength, making them suitable for packaging or coating materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Nuraziemah Ahmad, Chua Eng Wee, Lam Kok Wai, Noraziah Mohamad Zin, Fazren Azmi
Summary: Natural antimicrobial peptides (AMPs) are a promising source for new antimicrobial agents, but their clinical application is limited by poor bioavailability and toxicity. This study addresses these limitations by designing a new series of chitosan derivatives that mimic the structure of AMPs, with one derivative showing the most potent antimicrobial activity against Gram-negative bacteria while causing minimal cell death in tested cell lines. The results confirm the importance of cationicity and lipophilicity for selective bacteria targeting with the potential for chitosan nanoparticles as a new class of AMPs mimics effective against Gram-negative bacteria.
CARBOHYDRATE POLYMERS
(2021)
Article
Biotechnology & Applied Microbiology
Zuoqin Zhou, Caiyun Wang, Jingqi Bai, Zihan Zeng, Xiaoyu Yang, Bing Wei, Zheng Yang
Summary: This study reports a hybrid nanoparticle based on lactobionic acid modified chitosan and cinnamaldehyde modified chitosan, which possesses active tumor-targeting ability and ROS regulation ability, synergistic with the anti-tumor drug doxorubicin.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chaojie Xu, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Huahua Yu, Pengcheng Li
Summary: In this study, stable nanoparticles with good encapsulation efficiency and stability were successfully prepared using a novel method. The nanoparticles exhibited significant promotion of cytokine expression and showed favorable immune activity in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Luiza Izabela Toderascu, Livia Elena Sima, Stefana Orobeti, Paula Ecaterina Florian, Madalina Icriverzi, Valentin-Adrian Maraloiu, Cezar Comanescu, Nicusor Iacob, Victor Kuncser, Iulia Antohe, Gianina Popescu-Pelin, George Stanciu, Petre Ionita, Cristian N. N. Mihailescu, Gabriel Socol
Summary: In this study, L-Cysteine-coated magnetic iron oxide nanoparticles loaded with doxorubicin were synthesized and extensively characterized. The binding of doxorubicin to L-Cysteine was confirmed, and the internalization of the nanoparticles delivering doxorubicin was observed in melanoma cells. The nanoparticles also modulated cell signaling pathway activity, induced cell cycle arrest and apoptosis, and exhibited pH-dependent drug release. These results demonstrate the potential of the nanoparticles as efficient drug delivery vehicles in melanoma therapy.
Article
Chemistry, Multidisciplinary
Yufeng Lin, Cuixia Qiao, Zhihui Zhao, Yanzhi Xia, Gang Zhao, Zhixin Xue
Summary: A high-performance carrageenan/ZnO/chitosan composite film (F-CA/ZnO/CS) was fabricated using solution/dispersion casting and layer-by-layer methods. The film exhibited enhanced mechanical strength, transparency, and decreased water vapor transmission compared to carrageenan film (F-CA) and carrageenan/ZnO composite film (F-CA/ZnO). The addition of ZnO and CS also improved the antibacterial activity against Escherichia coli and Staphylococcus aureus. F-CA/ZnO/CS has the potential to be used in food packaging, wound dressings, and antimicrobial coatings.
Article
Biochemistry & Molecular Biology
Man Zhang, Zikun Li, Mengqi Dai, Hongjun He, Bin Liang, Chanchan Sun, Xiulian Li, Changjian Ji
Summary: Chitosan and pea protein isolate were used to prepare nanoparticles and their structures and functional properties were evaluated. The particle size and interface properties of the nanoparticles varied with different ratios, and the emulsifying activity was affected by the proportion of protein. The nanoparticles with a ratio of 1:1 showed the highest potential and the best thermal stability, while those with a ratio of 1:3 displayed a spherical morphology.
Article
Chemistry, Applied
Eduardo M. Costa, Sara Silva, Mariana Veiga, Patricia Baptista, Freni K. Tavaria, Manuela E. Pintado
Summary: By using eco-friendly chitosan nanoparticles for textile dyeing, it is possible to improve entrapment efficacy and show no cytotoxicity towards human skin cells.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Applied
Sapna Sethi, Medha, Balbir Singh Kaith
Summary: Chitosan-gelatin nanocomposites are emerging rapidly as a wide range of materials with diverse properties for biomedical applications. They provide a biocompatible and bioactive base, and can improve the mechanical strength and drug release capacity of the resulting material.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Wessam A. Abd-Elraoof, Ahmed A. Tayel, Shaymaa W. El-Far, Omar Mohamed Walid Abukhatwah, Amany M. Diab, Osama M. Abonama, Mona A. Assas, Asmaa Abdella
Summary: In this study, nanocomposites with antimicrobial and antioxidant properties were synthesized using biotechnological approaches, and their effectiveness in preserving chicken fillets was evaluated. The nanomaterials and composites were characterized and their antibacterial activities were assessed against various strains. Coating the chicken fillets with the nanomaterials resulted in a significant reduction in microbial count and improved sensory attributes.
Article
Chemistry, Applied
Tinnakorn Phuangkaew, Nadda Booranabunyat, Suda Kiatkamjornwong, Panida Thanyasrisung, Voravee P. Hoven
Summary: Hydrophobized chitosan derivatives with hydrophilic positively charged groups were synthesized and assembled into nanoparticles, showing effective anti-biofilm activity against the dental caries pathogen.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
