Article
Biochemistry & Molecular Biology
Adelina S. Plachokova, Sergio Andreu-Sanchez, Marlies P. Noz, Jingyuan Fu, Niels P. Riksen
Summary: This study explores the relationship between the oral microbiome of periodontitis patients and disease severity and systemic inflammation. Significant differences in microbial composition were found between severe and mild periodontitis, particularly in subgingival microbiome, which was positively associated with systemic inflammatory markers like interleukin-6 and white blood cell count. The findings suggest that systemic inflammation in severe periodontitis may be driven by the oral microbiome, supporting the indirect inflammatory mechanism linking periodontitis to cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Marlies P. Noz, Adelina S. Plachokova, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Siroon Bekkering, Prya Vart, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Summary: Periodontitis-associated bacteria can induce trained immunity in monocytes, accelerating atherosclerosis development. Patients with severe periodontitis showed signs of increased systemic inflammation and hematopoietic tissue activation, but their circulating monocytes did not exhibit a hyperresponsive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Weiqi Li, Jiakuan Peng, Qianhui Shang, Dan Yang, Hang Zhao, Hao Xu
Summary: This study found that moderate/severe periodontitis is associated with increased all-cause and cardiovascular disease-related mortality in adults with diabetes. Periodontitis may represent a marker for residual risk.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kuangyun Tang, Yongjia Wu, Qianhan Zheng, Xuepeng Chen
Summary: This study used bibliometric methods to investigate the relationship between periodontitis and cardiovascular diseases, finding that periodontal pathogens may link these two diseases and inflammation may be a significant shared factor. The study also identified emerging topics, such as COVID-19 and peri-implantitis, as having potential research value.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Alessia Pardo, Annarita Signoriello, Caterina Signoretto, Elena Messina, Maria Carelli, Maddalena Tessari, Nunzio Davide De Manna, Cecilia Rossetti, Massimo Albanese, Giorgio Lombardo, Giovanni Battista Luciani
Summary: This observational study investigated the presence of periodontal disease and oral pathogens in patients requiring aortic valve replacement. The study found a qualitative comparison between oral and cardiac profiles of microorganisms, suggesting a potential link between periodontal bacteria and valvular tissue in patients with periodontitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mireya Martinez-Garcia, Roberto Carlos Castrejon-Perez, Adriana Patricia Rodriguez-Hernandez, Santiago Sandoval-Motta, Maite Vallejo, Socorro Aida Borges-Yanez, Enrique Hernandez-Lemus
Summary: Cardiovascular diseases are the leading global cause of morbidity and mortality, with high blood pressure increasing rapidly worldwide. The study aims to explore the association between periodontal disease, microbiome, and hypertension in a cohort from Mexico City, using statistical and machine learning approaches. Implications for public health policy and population empowerment through primary prevention recommendations will be considered.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Julia I. P. van Heck, Ranko Gacesa, Rinke Stienstra, Jingyuan Fu, Alexandra Zhernakova, Hermie J. M. Harmsen, Rinse K. Weersma, Leo A. B. Joosten, Cees J. Tack
Summary: The gut microbiome in patients with type 1 diabetes is altered and associated with glycemic control and diabetes-related complications. Factors such as HbA(1c) and disease duration play a significant role in the variation of the gut microbiome, while micro- and macrovascular complications also contribute to this variation.
Article
Biochemistry & Molecular Biology
Federica Barutta, Stefania Bellini, Marilena Durazzo, Gabriella Gruden
Summary: Periodontitis and diabetes have a bidirectional relationship, with recent studies confirming a potential causal link between the two and highlighting the importance of host response. Trained immunity may serve as a unifying mechanism explaining the intertwined association between the two diseases.
Article
Dentistry, Oral Surgery & Medicine
Nathan Yip, Chuwen Liu, Di Wu, Ashraf F. Fouad
Summary: The study found a significant association between T2DM and AP prevalence, with the use of metformin and statins associated with a lower prevalence of AP. Poorly controlled glycemia was also significantly associated with a greater prevalence of AP.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Antonio E. Pesaro, Marcio Sommer Bittencourt, Marcelo Franken, Jose A. M. Carvalho, Daniel Bernardes, Jaakko Tuomilehto, Raul D. Santos
Summary: The FINDRISC score is associated with the development of type 2 diabetes mellitus and inflammation, showing good predictive value for incident T2DM but less accuracy for inflammation.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Nanoscience & Nanotechnology
Jessica A. Ferreira, Karla Z. Kantorski, Nileshkumar Dubey, Arwa Daghrery, J. Christopher Fenno, Yuji Mishina, Hsun-Liang Chan, Gustavo Mendonca, Marco C. Bottino
Summary: This study developed personalized antibiotic-laden scaffolds for periodontitis treatment using electrospinning techniques. Evaluation through chemo-morphological analyses, cytocompatibility assessment, and antimicrobial validation showed promising results for promoting new bone formation, reducing bone loss, and lowering inflammatory response. The fabrication of defect-specific antibiotic-laden scaffolds holds potential for personalized medication and regenerative properties.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Julia I. P. van Heck, Therese W. Fabricius, Rinke Stienstra, Steven Teerenstra, Rory J. McCrimmon, Cees J. Tack, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: Iatrogenic hypoglycemia activates the immune system and is associated with an increased risk of atherosclerotic disease. The study found that hypoglycemia induces a sustained inflammatory response at the cellular and protein level, which is present in both individuals with type 2 diabetes and control subjects.
Article
Dentistry, Oral Surgery & Medicine
M. Liu, J. Shao, Y. Zhao, B. Ma, S. Ge
Summary: Porphyromonas gingivalis can escape antimicrobial autophagy by promoting lysosome efflux to block autophagic maturation and survive within host cells. This leads to cellular oxidative stress, mitochondrial damage, and inflammatory responses. P. gingivalis may survive in the host by promoting lysosome efflux, blocking autophagosome-lysosome fusion, and disrupting autophagic flux, causing oxidative stress and inflammation.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Eva Munoz Aguilera, Jean Suvan, Marco Orlandi, Queralt Miro Catalina, Jose Nart, Francesco D'Aiuto
Summary: Recent evidence suggests a close relationship between hypertension and periodontitis, with individuals suffering from periodontitis showing higher systolic and diastolic blood pressure compared to those without. The diagnosis of periodontitis is associated with higher systolic blood pressure independently from common cardiovascular risk factors. Promoting periodontal and systemic health strategies may help reduce the burden of hypertension and its complications.
Article
Biochemistry & Molecular Biology
Oelisoa M. Andriankaja, Reuben Adatorwovor, Alpdogan Kantarci, Hatice Hasturk, Luciana Shaddox, Michael A. Levine
Summary: This study assessed the association between serum or gingival crevicular fluid endothelial and inflammatory mediators and chronic periodontal disease among Hispanic adults with type 2 diabetes. The findings showed that oral and systemic endothelial and inflammatory mediators are related to periodontal clinical parameters.
Article
Cardiac & Cardiovascular Systems
Angela Sciacqua, Elena Succurro, Giuseppe Armentaro, Sofia Miceli, Daniele Pastori, Giuseppe Rengo, Giorgio Sesti
Summary: Heart failure and type 2 diabetes are two important public health problems, especially among the elderly. Certain antidiabetic drugs should be used with caution in elderly individuals due to the risk of hypoglycemia and fluid retention. GLP-1 RAs and SGLT2 inhibitors have shown positive effects on cardiovascular outcomes. Treatment of diabetic elderly patients with heart failure should be based on scientific evidence, clinical judgment, and consideration for their dignity and quality of life.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto M. Marra, Roberta D'Assante, Andrea Salzano, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo, Giuseppe Limongelli, Daniele Masarone, Maria Perticone, Antonio Cimellaro, Pasquale Perrone Filardi, Stefania Paolillo, Paola Gargiulo, Antonio Mancini, Maurizio Volterrani, Olga Vriz, Roberto Castello, Andrea Passantino, Michela Campo, Pietro A. Modesti, Alfredo De Giorgi, Michele Arcopinto, Anna D'Agostino, Valeria Raparelli, Andrea M. Isidori, Valeria Valente, Federica Giardino, Giulia Crisci, Angela Sciacqua, Marcella Savoia, Toru Suzuki, Eduardo Bossone, Antonio Cittadini
Summary: This study investigated the prognostic impact of testosterone deficiency (TD) on women with heart failure with reduced ejection fraction (HFrEF). It found that around one-third of women with HFrEF had TD, which significantly affected their morbidity and mortality. TD was associated with a worse clinical profile including exercise capacity, right ventricular-pulmonary arterial coupling, and renal function.
Article
Medicine, General & Internal
Leonardo Bencivenga, Klara Komici, Stefania Paolillo, Carmela Nappi, Paola Gargiulo, Roberta Assante, Giuseppina Gambino, Fabio Santillo, Grazia Daniela Femminella, Grazia Maria Corbi, Nicola Ferrara, Alberto Cuocolo, Pasquale Perrone-Filardi, Giuseppe Rengo
Summary: The study found a weak association between cardiac sympathetic innervation and risk scores for predicting mortality in patients with heart failure. Therefore, it is recommended to integrate tools indicative of both arrhythmic and general mortality risks when evaluating patients eligible for device implantation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Psychology, Clinical
Natascia De Lucia, Giovanni Carbone, Benedetta Muzii, Nicola Ferrara, Giuseppe Rengo, Nelson Mauro Maldonato, Grazia Daniela Femminella
Summary: This study aimed to evaluate the association between neuropsychiatric symptoms, cognitive function, regional tau deposition, and brain volumes in MCI subjects. The results showed that 61.4% of MCI subjects had at least one neuropsychiatric symptom, with depression, irritability, and sleep disturbances being the most prevalent. MCI subjects with neuropsychiatric symptoms showed significant differences in cognitive tests of frontal and executive functions and reduced brain volumes in the orbitofrontal and posterior cingulate cortices.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Editorial Material
Environmental Sciences
Daniela Adamo, Gianrico Spagnuolo
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Rohan Diwakar, Rosaria Bucci, Ankur Kaushik, Anubhav Bansal, Paolo Bucci, Anuraj Singh Kochhar, Gianrico Spagnuolo
Summary: The aim of this study was to use CBCT to investigate the condyle-fossa relationship, TMJ morphology, and facial asymmetry in subjects with different vertical skeletal growth patterns. Results showed that the hyperdivergent group had larger anterior joint space and smaller condylar dimensions compared to the normodivergent and hypodivergent groups. Additionally, the right condylar distances to the midsagittal plane were significantly larger than the left distances in all three groups. Facial asymmetry values did not differ among the different vertical groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Salvatore Sauro, Gianrico Spagnuolo, Carmela Del Giudice, Davino M. Andrade Neto, Pierre B. A. Fechine, Xiaohui Chen, Sandro Rengo, Xiaojing Chen, Victor P. Feitosa
Summary: This study evaluated the cytotoxicity, chemical and structural properties of fluoride-doped calcium-phosphates as potential remineralising materials for dental applications. Experimental calcium phosphates were tested for their ability to crystallise into apatite-like and their fluoride release. The materials showed biocompatibility and the ability to promote cell proliferation, indicating their potential use as remineralising materials in dentistry.
Article
Chemistry, Multidisciplinary
Alessandra Valletta, Kioumars Tavakoli Tafti, Kimia Baghaei, Amirhossein Moaddabi, Parisa Soltani, Gianrico Spagnuolo, Akhilanand Chaurasia
Summary: Fractal analysis was used to evaluate the trabecular pattern of the mandibular condyle, angle, and dental region in individuals with and without bruxism using panoramic radiographs. No significant differences were found in the fractal dimension values of the regions of interest between the two groups. Fractal analysis of panoramic radiographs is not useful in detecting patients with bruxism.
APPLIED SCIENCES-BASEL
(2023)
Review
Clinical Neurology
Liliana Szyszka-Sommerfeld, Magdalena Sycinska-Dziarnowska, Gianrico Spagnuolo, Krzysztof Wozniak
Summary: Temporomandibular disorders (TMD) are prevalent painful conditions affecting the orofacial region. Surface electromyography (sEMG) is a useful method for assessing patients with TMD-P. Results showed differences in masticatory muscle activity (MMA) between TMD-P patients and healthy controls. The diagnostic efficacy of sEMG in TMD-P remains unclear.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Niccolo Giuseppe Armogida, Alessandra Valletta, Elena Calabria, Federica Canfora, Carlo Rengo, Gianrico Spagnuolo
Summary: This study proposes the use of Nd:YAG laser with low energy levels to treat labial venous lakes. All patients achieved complete healing within 30 days, with patients with a diameter <= 6 mm showing complete resolution after 7 days. The study suggests that Nd:YAG laser treatment is an effective and well-tolerated approach to aesthetic treatment of labial venous lakes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Mauro Cataldi, Camilla Celentano, Leonardo Bencivenga, Michele Arcopinto, Chiara Resnati, Annalaura Manes, Loreta Dodani, Lucia Comnes, Robert Vander Stichele, Dipak Kalra, Giuseppe Rengo, Francesco Giallauria, Ugo Trama, Nicola Ferrara, Antonio Cittadini, Maurizio Taglialatela
Summary: This study identified drug interaction perpetrators among drugs prescribed to older adults and analyzed the prevalence of gene polymorphisms that can increase their interacting potential. The study also found that few commercial clinical decision support systems include pharmacogenomic factors in drug-drug interaction risk evaluation, and none of them are designed for use in older adults.
Editorial Material
Biochemistry & Molecular Biology
Alessandro Cannavo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Parisa Soltani, Jaber Yaghini, Kosar Rafiei, Mojdeh Mehdizadeh, Niccolo Giuseppe Armogida, Luigi Esposito, Gianrico Spagnuolo
Summary: The accuracy of measuring gingival thickness was investigated by comparing clinical evaluation and intraoral ultrasonography. The study found that there was no significant difference in gingival thickness between ultrasonography and clinical evaluation in the anterior region, but there was a significant difference in the posterior region. The area under the ROC curve values indicated that ultrasonography had acceptable accuracy in determining gingival thickness, particularly in the anterior region.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Jacek Switala, Magdalena Sycinska-Dziarnowska, Gianrico Spagnuolo, Krzysztof Wozniak, Katarzyna Mankowska, Liliana Szyszka-Sommerfeld
Summary: This review examines the current scientific evidence on the oral microflora in children with cleft lip and/or palate (CLP). The results of the available studies are inconclusive, and further research is needed to gain a comprehensive understanding of the oral microbiota and potential implications for oral health management in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Federica Canfora, Elena Calabria, Gianrico Spagnuolo, Noemi Coppola, Niccolo Giuseppe Armogida, Cristina Mazzaccara, Domenico Solari, Luca D'Aniello, Massimo Aria, Giuseppe Pecoraro, Michele Davide Mignogna, Stefania Leuci, Daniela Adamo
Summary: This study analyzed a large sample of 500 BMS patients with different symptom combinations and found that xerostomia is the most frequent additional symptom. The study also identified various sociodemographic, psychological, and medical factors associated with different symptom subgroups. Further research is needed to understand the underlying causes and develop tailored treatment approaches for BMS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)