期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 132, 期 -, 页码 87-96出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.03.192
关键词
Novel polysaccharides; Sorghum bicolor (L); Chemical structure; Antioxidant and hemolytic activity; Laser burn wound healing
资金
- Laboratoy of Microorganisms and Biomolecules of the Center of Biotechnology of Sfax [LRCBS05]
- Ministry of Higher Education and Scientific Research, Tunisia
This work was undertaken to determine the structural characteristics of a novel polysaccharide, Sorghum Water Soluble Polysaccharide (SWSP), extracted from Sorghum (Sorghum bicolor (L)) seeds and to assess its in vitro hemolytic and antioxidant activities as well as its in vivo wound healing ability to treat burns induced by fractional CO2 laser. Results obtained by C-13,H-1 and HSQC Nuclear magnetic resonance (NMR) indicated that SWSP showed the characteristic bands of polysaccharides. Scanning electron microscopy of SWSP showed a rough surface with numerous cavities. SWSP exhibited strong antioxidant activities determined through three different assays: ferrous chelating activity, reducing power and DNA nicking. Also, no hemolytic activity was detected towards human erythrocytes. On the other hand, the application of SWSP hydrogel on the burn site in a rat model significantly improved wound appearance and accelerated the wound closure after 8 days of induction. Histological assessment of biopsies also demonstrated complete re-epithelialized wounds with a full epidermal regeneration. Thus, SWSP hydrogel which was efficient on wound closure might be useful as a wound healing agent in modern medicine. (C) 2019 Published by Elsevier B.V.
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