Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ali A. Shati, J. Alkabli, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Reda F. M. Elshaarawy, Waleed M. Serag, Yasser A. Hassan
Summary: This study compared the effects of bone marrow-derived mesenchymal stem cells (BMSCs) and crab chitosan nanoparticles (CCNPs) on renal fibrosis in cisplatin-induced kidney injury rats. The results showed that CCNPs and BMSC treatment had protective effects on renal function, with CCNPs administration showing more improvement of kidney damage resembling normal cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ejaz R. Dar, Mudasir B. Gugjoo, Moien Javaid, Shahid Hussain, Mujeeb R. Fazili, Kuldeep Dhama, Taha Alqahtani, Ali M. Alqahtani, Riaz A. Shah, Talha Bin Emran
Summary: The study evaluates the influence of ambient temperature, donor physiological status, and tissue source on sheep mesenchymal stem cells. Results show that adipose tissue-derived MSCs from full term pregnant female sheep exhibit higher potential for proliferation and differentiation compared to male sheep-derived MSCs. Cryopreserved MSCs have similar characteristics to fresh cells. Therefore, it is important to consider tissue type and donor physiological status when applying MSCs in clinical settings.
Article
Cell Biology
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee
Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Sanghyuk Choi, Jinyeong Yu, Wootak Kim, Ki-Sook Park
Summary: In this study, N-cadherin was identified as a key molecule in mediating the migration of BM-MSCs towards breast tumors. The expression of N-cadherin increased on the intercellular borders of BM-MSCs through TGF-beta canonical signaling, leading to their collective migration in response to breast tumor cells via N-cadherin-dependent cell-cell adhesion. This introduces a novel and promising strategy for controlling and re-engineering the breast tumor microenvironment.
Article
Biochemistry & Molecular Biology
Elise Aasebo, Annette K. Brenner, Maria Hernandez-Valladares, Even Birkeland, Frode S. Berven, Frode Selheim, Oystein Bruserud
Summary: Although the proteomic profiles of osteoblasts and MSCs show many similarities, there are still several specific differences, including extracellular matrix proteins and intracellular signaling networks. Targeting these specific proteins therapeutically may have minor effects on MSCs, and careful standardization of ex vivo handling will be required for the clinical use of cultured osteoblasts/MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Applied
Chang Su, Xiaojie Sun, Yuzhi Mu, Piwu Li, Jing Li, Pengsheng Fan, Mengxue Zhang, Mengyang Wang, Xiguang Chen, Chao Feng
Summary: A multilayer calcium alginate beads were designed for sewage treatment, combining organic matter degradation and metal ions absorption, which significantly improves the efficiency of wastewater treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Xiaojie Sun, Jing Li, Kai Shao, Chang Su, Shichao Bi, Yuzhi Mu, Kaichao Zhang, Zheng Cao, Xiaoye Wang, Xiguang Chen, Chao Feng
Summary: The AC-DB sponge demonstrated rapid hemostatic ability and good biocompatibility, activating intrinsic coagulation pathway to accelerate clotting process, with shortest clotting time and minimal blood loss in vivo assessments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Xin Cong, Yuzhi Mu, Di Qin, Xiaojie Sun, Chang Su, Tongtong Chen, Xiaoye Wang, Xiguang Chen, Chao Feng
Summary: A new Cu-DBs developed for infected wound therapy showed enhanced photothermal and photodynamic performance, achieving high antibacterial efficiency and promoting wound healing effectively.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Tongtong Chen, Feifei Wu, Yang Li, Hussein E. Rozan, Xiguang Chen, Chao Feng
Summary: A label-free photoluminescence immune-detection platform based on functionalized diatom frustules was developed, showing high sensitivity and a wide detection range. The platform has the potential for sensitive quantitative analysis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Zheng Cao, Chang Su, Xiaojie Sun, Kai Shao, Xiaoye Wang, Yuzhi Mu, Xiguang Chen, Chao Feng
Summary: The temperature-sensitive hydrogel composed of diatom biosilica and hydroxybutyl chitosan shows significantly enhanced mechanical strength and favorable blood compatibility and biocompatibility. By adjusting the ratio of diatom biosilica and hydroxybutyl chitosan, the properties of the hydrogel can be flexibly controlled.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Xiaoye Wang, Yuzhi Mu, Kuikun Yang, Kai Shao, Xin Cong, Zheng Cao, Xiaojie Sun, Chang Su, Xiguang Chen, Chao Feng
Summary: In this study, we proposed a novel solution for reversible regulation of reactive oxygen species (ROS) levels using a semiconductor heterojunction. By integrating two metal-based ROS scavengers, a n-type CeO2 nanoparticles and a n-type Cu-doped diatom biosilica, a cascade catalytic reaction was activated to quickly eliminate ROS, while a near-infrared (NIR)-triggered photocatalytic effect switched to ROS generation. This reversible ROS regulation system provided a noninvasive strategy for controlling ROS levels both in vitro and in vivo, which can relieve cellular oxidative stress and inhibit bacterial growth.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Chang Su, Changqing Jiang, Xiaojie Sun, Zheng Cao, Yuzhi Mu, Xin Cong, Kaijin Qiu, Jiawen Lin, Xiguang Chen, Chao Feng
Summary: This study developed diatomite hemostatic granules through rotating granulation method, which showed rapid hemostatic ability and good biocompatibility. The granules retained the porous structure of diatomite, exhibited strong clotting ability, and had no side effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Multidisciplinary
Di Qin, Xinguo You, Haonan Wang, Yixuan Liu, Yan Shi, Na Wang, Xin Zhang, Chao Feng, Ya Liu, Ming Kong, Xiaojie Cheng, Shichao Bi, Xiguang Chen
Summary: Surface topography of fish scales promotes bone regeneration by directing cell behavior and modulating the osteoimmune microenvironment. The anisotropic ridged micropatterns and mineralized collagen on the scales induce macrophage polarization and stimulate anti-inflammatory cytokine secretion. In addition, they enhance osteogenic differentiation of mesenchymal stem cells and increase bone formation. The findings suggest that fish scales can be a potential implant material for bone repair.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Engineering, Biomedical
Xu Qiu, Chao Feng, Wenxuan Wang, Guangsheng Wu, Yingzhe Hu, Shuhan Li, Xiangru Gao, Xiguang Chen, Qiuxia Ji
Summary: This study demonstrated that copper-deposited Diatom-biosilica (Cu-DBs) have the potential to repair bone defects caused by inflammation. Cu-DBs promoted osteogenesis and angiogenesis, as well as inhibited inflammatory responses and reduced immune cell infiltration. In vitro and in vivo experiments confirmed the osteogenic properties of Cu-DBs. The unique chemical characteristics of Cu2+ and Si4+ ions enhanced the osteogenic differentiation of periodontal ligament stem cells and stimulated osteogenesis in rats.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Chenfei Yang, Chao Feng, Yuhang Li, Zheng Cao, Yan Sun, Xiaohui Li, Lin Zhang, Chengxu Zhou, Jichang Han
Summary: Diatoms, with their silicified cell wall known as frustule, are crucial to marine primary production. The frustule provides various benefits to diatoms, including nutrient uptake, UV protection, predator deterrent, parasite resistance, light harvesting, CO2 capture, and position control. Moreover, as an exquisite biosilica, the frustule holds great potential as bionanomaterials in the biomedical field. This review explores the morphological and physicochemical characteristics of the frustule, as well as its biological functions and biomedical applications.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Xiaojie Sun, Na Li, Chang Su, Yuzhi Mu, Xin Cong, Zheng Cao, Xiaoye Wang, Xiaoyan Yang, Xiguang Chen, Chao Feng
Summary: In this study, a diatom-inspired bionic hydrophilic polysaccharide adhesive was developed for rapid hemostasis. The adhesive exhibited strong mechanical strength and viscosity, and maintained adhesion ability in wet environments. The dry adhesive prepared by lyophilization also showed excellent clotting ability for anticoagulant whole blood.
Article
Chemistry, Physical
Chang Su, Zheng Cao, Jiahao Liu, Xiaojie Sun, Kaijin Qiu, Yuzhi Mu, Xin Cong, Xiaoye Wang, Xiguang Chen, Nan Jia, Chao Feng
Summary: We developed a Ca2+ modified diatom biosilica-based hemostat (DBp-Ca2+) with a hierarchical porous structure. The unique porous size arrangement of DBp-Ca2+ allows for selective adsorption during coagulation process, resulting in rapid hemorrhage control. In vitro and in vivo studies confirmed that DBp-Ca2+ has high porosity, water absorption, protein absorption, and can accelerate blood exchange and reduce thrombosis time.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Marine & Freshwater Biology
Qinfeng Li, Zheng He, Hussein. E. Rozan, Chao Feng, Xiaojie Cheng, Xiguang Chen
Summary: The influence of Ca2+ biomineralization on diatom biosilica (DBs) was explored to develop fast hemostatic materials with a low hemolysis rate. Ca-DBs-3 exhibited good biocompatibility, rapid hemostatic effect, and non-hemolysis, making it a potential candidate for diatom biosilica hemostatic materials.
MARINE LIFE SCIENCE & TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Xiaojie Sun, Mengxue Zhang, Jinfeng Liu, Guangyan Hui, Xiguang Chen, Chao Feng
Summary: Diatom biosilica is a natural inorganic material with a micro-nanoporous structure and has great application potential in drug delivery, hemostat materials, and biosensors. Manipulating the micro-nanostructure of diatom biosilica through biological regulation methods can transform the screening mode of its structural features and maximize its possibility as a biological material.
Article
Materials Science, Biomaterials
Xiaojie Sun, Na Li, Xiaolei Wang, Yuzhi Mu, Chang Su, Xin Cong, Xiaoye Wang, Feifei Wu, Guangsheng Wu, Xiguang Chen, Chao Feng
Summary: In this study, a hybrid hemostatic gauze (MG-PEG) was prepared by template method for hemorrhage control. It exhibited superior hemostatic performance and wider indications range for practical application.
BIOMATERIALS ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
