HIMF (Hypoxia-Induced Mitogenic Factor)-IL (Interleukin)-6 Signaling Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Hypertrophy and Fibrosis

Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism

(2018) Sumia A. Bageghni et al.   FASEB JOURNAL

Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α MechanismsNovelty and Significance

(2018) Santosh Kumar et al.   HYPERTENSION

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

(2018) Nikolaos G. Frangogiannis   MOLECULAR ASPECTS OF MEDICINE

Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and DysfunctionNovelty and Significance

(2016) Lin Zhao et al.   CIRCULATION RESEARCH

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial

(2016) Ola Kleveland et al.   EUROPEAN HEART JOURNAL

Role of TGF Beta and PPAR Alpha Signaling Pathways in Radiation Response of Locally Exposed Heart: Integrated Global Transcriptomics and Proteomics Analysis

(2016) Vikram Subramanian et al.   JOURNAL OF PROTEOME RESEARCH

Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)–Induced Pulmonary HypertensionSignificance

(2015) Roger A. Johns et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

(2014) Karim C. El Kasmi et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

IL-6 and its receptors in coronary artery disease and acute myocardial infarction

(2013) Daniel R. Anderson et al.   CYTOKINE

The problem of choice: current biologic agents and future prospects in RA

(2013) Ernest H. Choy et al.   Nature Reviews Rheumatology

Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) in chronic hypoxia- and antigen-mediated pulmonary vascular remodeling

(2013) Daniel J Angelini et al.   RESPIRATORY RESEARCH

Interleukin 6 Mediates Myocardial Fibrosis, Concentric Hypertrophy, and Diastolic Dysfunction in Rats

(2010) Giselle C. Meléndez et al.   HYPERTENSION

High-mobility group box 1 (HMGB1) downregulates cardiac transient outward potassium current (Ito) through downregulation of Kv4.2 and Kv4.3 channel transcripts and proteins

(2010) Wenjuan Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) induces the vascular and hemodynamic changes of pulmonary hypertension

(2009) Daniel J. Angelini et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Calcineurin activates interleukin-6 transcription in mouse skeletal muscle in vivo and in C2C12 myotubes in vitro

(2009) David L. Allen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Crucial Role of Interleukin-6 in the Development of Norepinephrine-induced Left Ventricular Remodeling in Mice

(2009) Henning Meier et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS