Article
Medicine, Research & Experimental
Yelda A. Leal, Minkyo Song, Jovanny Zabaleta, Gilberto Medina-Escobedo, Patrick Caron, Aurelio Lopez-Colombo, Chantal Guillemette, M. Constanza Camargo
Summary: The study suggests that higher levels of circulating DHEA may be associated with a lower risk of noncardia gastric cancer, while estradiol and testosterone levels were not significantly linked to gastric cancer. Further longitudinal studies are needed to explore the temporality of this association and the mechanisms of disease pathogenesis.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Theresa W. Cheng, Lucia Magis-Weinberg, Victoria Guazzelli Williamson, Cecile D. Ladouceur, Sarah L. Whittle, Megan M. Herting, Kristina A. Uban, Michelle L. Byrne, Marjolein E. A. Barendse, Elizabeth A. Shirtcliff, Jennifer H. Pfeifer
Summary: The ABCD Study is a long-term research project on adolescent development that provides rich data resources for researchers. By offering recommendations on the use of pubertal variables and conducting cross-sectional empirical analysis, researchers can better understand the characteristics of adolescent development, thus advancing the field.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicholas D. Fried, Anna Whitehead, Eric Lazartigues, Xinping Yue, Jason D. Gardner
Summary: This study using a bilateral ovariectomy model suggests that the cardiopulmonary protection observed in nicotine-exposed female mice may be independent of ovarian hormones.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Qiao Zhu, Ping Ping, Pei Zhang, Chaoxue Ning, Yali Zhao, Yao Yao, Xiubing Li, Shihui Fu
Summary: This study explored the relationship between sex hormone levels and physical function in Chinese oldest-old and centenarian women. The results showed that age and estradiol levels were negatively associated with activities of daily living in all participants.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Victoria-Luise Batury, Friederike I. Tam, Inger Hellerhoff, Marie-Louis Wronski, Katrin Borucki, Kerstin Weidner, Veit Roessner, Wei Gao, Stefan Ehrlich
Summary: Anorexia nervosa (AN) is a complex psychiatric disorder that affects endocrine system. Previous short-term measurement methods have shown altered levels of sex steroid hormones in AN patients. This study aimed to use hair-based assessments to investigate sex steroid hormone levels in underweight AN patients compared to healthy controls, as well as the changes in hormone levels during inpatient treatment. The results indicate that hair hormone levels of DHEA were similar between the groups, but progesterone was suppressed in underweight AN patients. There was no significant change in hair hormone levels during weight restoration. Hair analysis can be used to detect suppressed progesterone levels in severe AN patients.
Review
Neurosciences
Nada Aloufi, Antje Heinrich, Kay Marshall, Karolina Kluk
Summary: This study aims to discuss sex differences in auditory function between women and men, and whether cyclic fluctuations in female sex hormones affect auditory function in pre-menopausal and post-menopausal women. The systematic review identified consistent sex differences in auditory function, fluctuations in hearing function across the menstrual cycle, and the onset of hearing loss in menopause. Well-designed and controlled studies are needed to evaluate the influence of female sex hormones on hearing and should include control groups and objective measurements of hormonal levels.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Ke Xu, Yicheng Fu, Buzi Cao, Mingyi Zhao
Summary: This study aims to evaluate the association between sex hormones and sex hormone-binding globulin (SHBG) with bone mineral density (BMD) in adolescents. The results show differences in the association of sex hormones with BMD in boys and girls, where an appropriate increase in serum testosterone levels may be beneficial for skeletal development in girls and keeping estradiol levels below a certain level in boys may be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Tatjana Tasic, Marijana Tadic, Maja Lozic
Summary: Hypertension is a major cause of illness and death in the human population, but the pathophysiological mechanisms leading to hypertension in women are not fully understood. From young age to old age, women's bodies go through different stages with specific physiological features and susceptibility to certain diseases, making it challenging to understand the genesis and treatment of hypertension in women. Clinical and experimental findings highlight the roles of sex hormones, the autonomic nervous system, the renin-angiotensin-aldosterone system, and arterial stiffness in the development of chronically elevated blood pressure in females. The purpose of this review is to briefly summarize the knowledge of the mechanisms and treatment of hypertension in women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Anna Beltrame, Pedro Salguero, Emanuela Rossi, Ana Conesa, Lucia Moro, Laura Rachele Bettini, Eleonora Rizzi, Mariella D'Angio, Michela Deiana, Chiara Piubelli, Paola Rebora, Silvia Duranti, Paolo Bonfanti, Ilaria Capua, Sonia Tarazona, Maria Grazia Valsecchi
Summary: This study investigates the association between sex hormone levels and outcomes in COVID-19 patients, stratified by sex and age. The results show that lower testosterone levels are linked to the occurrence of ARDS and severe COVID-19 in older males, while higher estradiol levels are associated with an increased risk of death. Testosterone levels are negatively associated with ARDS, severe COVID-19, and in-hospital mortality, while estradiol levels are positively associated with the risk of death.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Andrea L. Frump, Marjorie Albrecht, Bakhtiyor Yakubov, Sandra Breuils-Bonnet, Valerie Nadeau, Eve Tremblay, Francois Potus, Junichi Omura, Todd Cook, Amanda Fisher, Brooke Rodriguez, R. Dale Brown, Kurt R. Stenmark, C. Dustin Rubinstein, Kathy Krentz, Diana M. Tabima, Rongbo Li, Xin Sun, Naomi C. Chesler, Steeve Provencher, Sebastien Bonnet, Tim Lahm
Summary: This study identifies a novel cardioprotective mechanism in the right ventricle where 17β-estradiol upregulates apelin expression via estrogen receptor α, potentially leading to alleviation of RV failure induced by pulmonary arterial hypertension. Understanding and harnessing this E2/ERα/BMPR2/apelin axis may offer new RV-targeted therapies for PAH patients of both sexes.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Public, Environmental & Occupational Health
Rong Lei, Yan Sun, Jiawen Liao, Yuan Yuan, Linlin Sun, Yugeng Liu, Xinyu Yang, Wenyou Ma, Zhenjian Yu
Summary: This study explored the correlation between the severity of depression in females and sex hormones, as well as differences in sex hormone levels among females of different ages. Results showed that sex hormone levels, especially estradiol, varied among females with depression of different ages, and recurrent depression also had an impact on sex hormone levels in females. It is important to not only consider age and relapse when studying sex hormone levels in females with depression, but also whether they have used antidepressants before hormonal testing.
Review
Cardiac & Cardiovascular Systems
Peng Hu, Jun Huang, Yi Lu, Murui Zheng, Haiyi Li, Xueru Duan, Hai Deng, Wenjing Zhao, Xudong Liu
Summary: This study aimed to evaluate the association between circulating sex hormones and the risk of atrial fibrillation (AF). Through a meta-analysis of multiple cohort studies, it was found that higher endogenous dehydroepiandrosterone sulfate (DHEAS) levels in men were associated with a lower risk of AF, while total testosterone and estradiol were not associated with AF risk. Further longitudinal studies are needed to explore the relationship between various circulating sex hormones and AF risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Ram P. Singh, David S. Bischoff
Summary: Gender and sex hormones can influence susceptibility to SLE by affecting regulatory T cells and FoxP3 expression, with females being more susceptible than males. Female SLE patients have higher estradiol levels and lower testosterone levels, which may lead to reduced T-regulatory cells and decreased FoxP3 expression, contributing to the increased susceptibility to SLE and other autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zhou Bingzheng, Zhao Xinzhuo, Jin Zhuo, Yang Xing, Li Bin, Bai Lunhao
Summary: This study investigated the effects of the menstrual cycle and serum sex hormone concentrations on knee kinematic parameters in female college soccer athletes. The results showed that subjects had a lower maximum knee valgus in the mid-luteal phase, indicating a lower risk of ACL injury. There was no significant correlation between serum sex hormone concentrations and knee kinematic parameters.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Surgery
Christina Villard, Joy Roy, Marko Bogdanovic, Per Eriksson, Rebecka Hultgren
Summary: In elderly men, higher levels of estradiol and progesterone were observed in those with AAA, while testosterone levels were lower. AAA was associated with elevated progesterone levels, smoking, coronary heart disease, and a body mass index >25 kg/m(2).
JOURNAL OF VASCULAR SURGERY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
David A. Bluemke
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
David A. Bluemke
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sarah L. Atzen, David A. Bluemke
Article
Cardiac & Cardiovascular Systems
Hilary F. Armstrong, David Lederer, Gina S. Lovasi, Grant Hiura, Corey E. Ventetuolo, RGraham Barr
Summary: This study investigated the relationship between depression and the use of selective serotonin reuptake inhibitors (SSRIs) in patients with chronic obstructive pulmonary disease (COPD). The results showed that patients taking SSRIs had lower FEV1 and a higher likelihood of experiencing dyspnea compared to those not taking antidepressants.
RESPIRATORY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Xiuna Sun, Erika Nakajima, Carmelissa Norbrun, Parand Sorkhdini, Alina Xiaoyu Yang, Dongqin Yang, Corey E. Ventetuolo, Julie Braza, Alexander Vang, Jason Aliotta, Debasree Banerjee, Mandy Pereira, Grayson Baird, Qing Lu, Elizabeth O. Harrington, Sharon Rounds, Chun Geun Lee, Hongwei Yao, Gaurav Choudhary, James R. Klinger, Yang Zhou
Summary: CHI3L1 is closely associated with pulmonary vascular disease, and its levels are positively correlated with the severity of PH. In mouse models, overexpression of CHI3L1 exacerbates pulmonary vascular disease, while its knockout mitigates the disease. Additionally, CHI3L1 can induce proliferation of pulmonary arterial smooth muscle cells and loss of endothelial barrier function.
Article
Radiology, Nuclear Medicine & Medical Imaging
Charlene A. Mauger, Kathleen Gilbert, Avan Suinesiaputra, David A. Bluemke, Colin O. Wu, Joao A. C. Lima, Alistair A. Young, Bharath Ambale-Venkatesh
Summary: This study aimed to quantify the relationship between left ventricular (LV) three-dimensional shape at MRI and incident cardiovascular events over 10 years. Results showed that adding LV remodeling signatures to traditional cardiovascular risk factors improved the prediction of heart failure, coronary heart disease, and cardiovascular disease events over 10 years.
Article
Multidisciplinary Sciences
Alger M. Fredericks, Maximilian S. Jentzsch, William G. Cioffi, Maya Cohen, William G. Fairbrother, Shivam J. Gandhi, Elizabeth O. Harrington, Gerard J. Nau, Jonathan S. Reichner, Corey E. Ventetuolo, Mitchell M. Levy, Alfred Ayala, Sean F. Monaghan
Summary: COVID-19 has impacted millions of patients worldwide. Deep RNA sequencing and computational biology analysis revealed the presence of SARS-CoV-2 RNA in both respiratory and blood samples of critically ill patients. Differential expression of immune modulating genes and alternative transcription and splicing events in certain proteins were associated with mortality in COVID-19 patients. Deep RNA sequencing with computational biology analysis can provide important prognostic information and guide therapeutic focus in future studies.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Maria Doughan, Omar Chehab, Henrique Doria de Vasconcellos, Ralph Zeitoun, Vinithra Varadarajan, Bassel Doughan, Colin O. Wu, Michael J. Blaha, David A. Bluemke, Joao A. C. Lima
Summary: A self-reported history of periodontal disease was found to be associated with increased measures of interstitial myocardial fibrosis in men, but not in women. This suggests a possible link between periodontal disease and subclinical myocardial fibrosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Critical Care Medicine
Bryan S. Blette, Jude Moutchia, Nadine Al-Naamani, Corey E. Ventetuolo, Chao Cheng, Dina Appleby, Ryan J. Urbanowicz, Jason Fritz, Jeremy A. Mazurek, Fan Li, Steven M. Kawut, Michael O. Harhay
Summary: This study aimed to determine whether pulmonary arterial hypertension (PAH) risk scores could serve as adequate surrogates for clinical worsening or mortality outcomes in PAH randomized clinical trials (RCTs). Through an individual participant data meta-analysis, the study found that these risk scores were not accurate predictors of long-term clinical worsening and survival improvement. Therefore, further study is necessary before using these risk scores or other scores as surrogate outcomes in PAH RCTs or clinical care.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Urology & Nephrology
Faeq Husain-Syed, Matthew F. DiFrancesco, Rajat Deo, R. Graham Barr, Julia J. Scialla, David A. Bluemke, Richard A. Kronmal, Joao A. C. Lima, Amy Praestgaard, Russell P. Tracy, Michael Shlipak, Steven M. Kawut, John S. Kim
Summary: Low glomerular filtration rate (GFR) and increased albuminuria are associated with all-cause and cardiovascular mortality. Limited data are available on the independent associations of GFR and albuminuria with cardiac morphology, especially in early chronic kidney disease (CKD). This study found that reductions in eGFR within the normal range and higher albuminuria were associated with smaller right ventricular volumes, and albuminuria had a stronger association with mortality among those with smaller RV volumes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tarek Zghaib, Thiago Quinaglia A. C. Silva, Bharath Ambale-Venkatesh, Eric Xie, Mohammad R. Ostovaneh, Mohammadali Habibi, David A. Bluemke, Elsayed Z. Soliman, Colin O. Wu, Susan R. Heckbert, Saman Nazarian, Joao A. C. Lima
Summary: The purpose of this study was to investigate the prevalence and correlates of left atrial late gadolinium enhancement (LGE) at cardiac MRI and its association with atrial fibrillation (AF). The results showed that LA LGE was associated with adverse atrial remodeling and independently predicted the development of AF in a multiethnic population-based sample.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2023)
Article
Respiratory System
Corey E. Ventetuolo, Jude Moutchia, Grayson L. Baird, Dina H. Appleby, Robyn L. McClelland, Jasleen Minhas, Jeff Min, John H. Holmes, Ryan J. Urbanowicz, Nadine Al-Naamani, Steven M. Kawut
Summary: This study found that sex differences have an impact on baseline 6-minute walk distance, hemodynamics, and functional class in pulmonary arterial hypertension (PAH). Females had shorter 6MWD, higher cardiac index, and lower right atrial pressure and mean pulmonary artery pressure. Age and body mass index modulated the relationship between sex and these outcomes. The study suggests that sex, age, and body size should be taken into consideration in the evaluation and interpretation of surrogate outcomes in PAH.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Daniel C. Yee, Debasree Banerjee, Sara E. Vargas, Melissa Allahua, Mary E. Whittenhall, Nicholas Perry, Corey E. Ventetuolo, Kate M. Guthrie
Summary: Women with pulmonary arterial hypertension (PAH) face challenges and burdens regarding sexual health-related quality of life (SHRQoL), including decreased frequency of sex, fear of intercourse due to cardiopulmonary symptoms, compensatory behaviors/strategies during sex, negative body image related to medications and oxygen supplementation, and the desire for more communication and discussion with healthcare professionals regarding sexual practices.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Correction
Respiratory System
J. Min, R. Feng, D. Badesch, E. Berman-Rosenzweig, C. Burger, M. Chakinala, Marco T. De, J. Feldman, A. Hemnes, E. M. Horn, M. R. Lammi, S. Mathai, J. W. McConnell, K. Presberg, J. Robinson, J. Sager, O. A. Shlobin, M. Simon, T. Thenappan, C. Ventetuolo, N. Al-Naamani
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Meeting Abstract
Critical Care Medicine
J. Minhas, G. Baird, D. Appleby, R. McClelland, J. Min, J. A. Mazurek, C. E. Ventetuolo, N. Al-Naamani, S. M. Kawut
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)