Article
Gastroenterology & Hepatology
Tsung-Hsien Chiang, Wei-Jung Chang, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Jean Ching-Yuan Fann, Sherry Yueh-Hsia Chiu, Yi-Ru Chen, Shu-Ling Chuang, Chun-Fu Shieh, Cheng-Ying Liu, Han-Mo Chiu, Hung Chiang, Chia-Tung Shun, Ming-Wei Lin, Ming-Shiang Wu, Jaw-Town Lin, Chang-Chuan Chan, David Y. Graham, Hsiu-Hsi Chen, Yi-Chia Lee
Summary: Mass eradication of H. pylori infection in a high-risk Taiwanese population significantly reduced gastric cancer incidence and showed potential for reducing mortality, with no significant changes in other digestive tract cancers or antibiotic resistance rates of H. pylori. Long-term follow-up may lead to further reductions in mortality rates.
Article
Multidisciplinary Sciences
Hiroto Noda, Mitsuru Kaise, Ryuichi Wada, Eriko Koizumi, Kumiko Kirita, Kazutoshi Higuchi, Jun Omori, Teppei Akimoto, Osamu Goto, Hiroshi Kawachi, Katsuhiko Iwakiri
Summary: The study found that the frequency and length ratio of internal surface type non-neoplastic epithelium (NE) were significantly higher in HP-eradicated gastric cancers, compared to HP-infected gastric cancers. Additionally, HP-eradicated gastric cancers showed a higher frequency of endoscopic findings like gastritis-like appearance (GLA), suggesting a correlation between NE types and HP eradication as well as certain endoscopic features.
Article
Gastroenterology & Hepatology
Zhan-Yue Niu, Si-Zhu Li, Yan-Yan Shi, Yan Xue
Summary: This study found that the effectiveness of quadruple H. pylori eradication therapy depended on gastric microbiota, and the high rate of H. pylori eradication was associated with the presence of Rhodococcus, Lactobacillus, and Sphingomonas.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Dan Li, Sheng-Fang Jiang, Nan Ye Lei, Shailja C. Shah, Douglas A. Corley
Summary: This large-scale retrospective cohort study in the United States investigated the incidence of noncardia gastric adenocarcinoma (NCGA) after Helicobacter pylori eradication therapy. The findings showed a significantly reduced risk of NCGA after 8 years of treatment compared to no treatment. This study highlights the potential for substantial gastric cancer prevention through H pylori eradication. Evaluation: 8 out of 10.
Review
Microbiology
Mariagrazia Piscione, Mariangela Mazzone, Maria Carmela Di Marcantonio, Raffaella Muraro, Gabriella Mincione
Summary: Gastric cancer is the fifth most common cancer worldwide and the third leading cause of death in developed countries, mainly caused by Helicobacter pylori which is considered a type I carcinogen. The development of gastric cancer involves a progression from gastritis to intestinal metaplasia and eventual adenocarcinoma, with steps including chronic non-atrophic gastritis triggered by H. pylori infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Immunology
Yang Guo, Xue-Shan Cao, Guan-Yi Guo, Meng-Ge Zhou, Bo Yu
Summary: Successful eradication of H. pylori can reverse dysbiosis of the gastric microbiota and have beneficial effects on the gastric microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Chun-Yan Weng, Jing-Li Xu, Shao-Peng Sun, Kai-Jie Wang, Bin Lv
Summary: H. pylori infection affects gastric mucosal functions significantly, and eradication can lead to functional recovery.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Hidehiko Takigawa, Ryo Yuge, Satoshi Masaki, Rina Otani, Hiroki Kadota, Toshikatsu Naito, Ryohei Hayashi, Yuji Urabe, Shiro Oka, Shinji Tanaka, Kazuaki Chayama, Yasuhiko Kitadai
Summary: For gastric MALT lymphoma cases that are Helicobacter pylori-negative and API2-MALT1-negative, a high rate of non-Helicobacter pylori Helicobacter infections was observed, which may have contributed to the success of eradication therapy. Therefore, eradication therapy is recommended as a first-line treatment for non-Helicobacter pylori Helicobacter-positive gastric MALT lymphoma.
Article
Gastroenterology & Hepatology
Akiko Kowada
Summary: The study assessed the cost-effectiveness of gastric cancer screening in patients with gastric mucosal atrophy after successful Helicobacter pylori eradication, and found that biennial endoscopy was the most cost-effective option.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Gil Ho Lee
Summary: This study investigated the long-term effect of Helicobacter pylori eradication on the prevention of metachronous gastric neoplasm after endoscopic submucosal dissection (ESD) of gastric adenoma. The results showed that eradication of H. pylori did not increase the risk of metachronous gastric neoplasm after ESD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Liang Wang, Jinfeng Wang, Sha Li, Fei Bai, Hailong Xie, Hanguo Shan, Zhuo Liu, Tiexiang Ma, Xiayu Tang, Haibing Tang, Ang Qin, Sanlin Lei, Chaohui Zuo
Summary: This retrospective study investigated the impact of Helicobacter pylori eradication on the prognosis of postoperative early gastric cancer (EGC). The findings suggest that H. pylori eradication treatment can prevent recurrence of postoperative EGC and prolong the overall survival of patients with EGC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Li-Qi Mao, Yan-Lin Zhou, Shuang-Shuang Wang, Lin Chen, Yue Hu, Lei-Min Yu, Jing-Ming Xu, Bin Lyu
Summary: This study investigated the impact of Helicobacter pylori eradication on the gastric microflora, revealing that successful eradication leads to partial recovery of the stomach microbiota. However, this restoration is incomplete and may pose long-term risks.
Article
Multidisciplinary Sciences
Oddmund Nestegard, Behrouz Moayeri, Fred-Arne Halvorsen, Tor Tonnesen, Sveinung Wergeland Sorbye, Eyvind Paulssen, Kay-Martin Johnsen, Rasmus Goll, Jon Ragnar Florholmen, Kjetil K. Melby
Summary: This study characterized the antimicrobial resistance pattern of H. pylori before and after treatment, and found that clarithromycin resistance was more frequent in the treatment-resistant group. No resistance was observed for amoxicillin and levofloxacin.
Article
Medicine, General & Internal
Xin Luo, Hui Li, Li He
Summary: The study found a correlation between age, endoscopic manifestations, and the effectiveness of H. pylori eradication therapy. Patients over 60 years old and those with multiple white and flat elevated lesions in endoscopic examination were more likely to fail H. pylori eradication with empirical quadruple therapy. On the other hand, patients with diffuse redness in endoscopic examination were more likely to succeed in H. pylori eradication therapy with empirical quadruple therapy.
FRONTIERS IN MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Satoki Shichijo, Noriya Uedo, Tomoki Michida
Summary: The review article examines the characteristics of primary and metachronous gastric cancers after H. pylori eradication, risk factors for their development, and the potential utility of image-enhanced endoscopy in diagnosing gastric cancer post-eradication. The study finds that a gastritis-like appearance with low-grade atypia may complicate early detection of cancer after eradication therapy, and identifies common risk factors for both primary and metachronous gastric cancers. Image-enhanced endoscopy, such as linked color imaging, is suggested as a useful tool for detection and risk stratification of gastric cancer post-eradication.