Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis

Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function

(2015) Michael G. Risbano et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease

(2015) J. A. Detterich et al.   BLOOD

Diversity of animal immune receptors and the origins of recognition complexity in the deuterostomes

(2015) Katherine M. Buckley et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration

(2015) David C. Irwin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity

(2015) Jeremy W. Deuel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autologous Transfusion of Stored Red Blood Cells Increases Pulmonary Artery Pressure

(2014) Lorenzo Berra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications

(2014) Felicitas S. Boretti et al.   Frontiers in Physiology

Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage

(2014) Iris C. Vermeulen Windsant et al.   Frontiers in Physiology

Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

(2013) Chris E. Cooper et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

(2013) Miriam Lipiski et al.   ANTIOXIDANTS & REDOX SIGNALING

Cell-Free Hemoglobin and Its Scavenger Proteins: New Disease Models Leading the Way to Targeted Therapies

(2013) D. J. Schaer et al.   Cold Spring Harbor Perspectives in Medicine

Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia

(2012) S. B. Solomon et al.   BLOOD

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe

(2012) M. Nouraie et al.   HAEMATOLOGICA

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetically Encoded Tetrazine Amino Acid Directs Rapid Site-Specific in Vivo Bioorthogonal Ligation with trans-Cyclooctenes

(2012) Jason L. Seitchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cardiovascular Abnormalities in Sickle Cell Disease

(2012) Mark T. Gladwin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Down Selection of Polymerized Bovine Hemoglobins for Use as Oxygen Releasing Therapeutics in a Guinea Pig Model

(2012) Jin Hyen Baek et al.   TOXICOLOGICAL SCIENCES

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

(2011) Chenell Donadee et al.   CIRCULATION

Endothelial Dysfunction Enhances Vasoconstriction Due to Scavenging of Nitric Oxide by a Hemoglobin-based Oxygen Carrier

(2010) Binglan Yu et al.   ANESTHESIOLOGY

Quantitative Mass Spectrometry Defines an Oxidative Hotspot in Hemoglobin that is Specifically Protected by Haptoglobin

(2010) Tatiana Pimenova et al.   JOURNAL OF PROTEOME RESEARCH

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design

(2010) Paul W. Buehler et al.   TRENDS IN MOLECULAR MEDICINE

Haptoglobin: Basic and Clinical Aspects

(2009) Andrew P. Levy et al.   ANTIOXIDANTS & REDOX SIGNALING

Evolutionary Aspects of Hemoglobin Scavengers

(2009) Krzysztof B. Wicher et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Inhaled Nitric Oxide Enables Artificial Blood Transfusion Without Hypertension

(2008) Binglan Yu et al.   CIRCULATION

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin

(2008) Ivan Azarov et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY