期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 140, 期 -, 页码 93-102出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2019.03.032
关键词
Reactive oxygen species; ROS defenses; Bacteria; Anaerobic; Aerobic; Superoxide dismutase; Catalase; Peroxidase
资金
- Ontario Graduate Scholarship
- Queen Elizabeth II Graduate Scholarship in Science and Technology
- Tier II Canada Research Chair
Bacteria are the most diverse and numerous organisms on the planet, inhabiting environments from the deep subsurface to particles in clouds. Across this range of conditions, bacteria have evolved a diverse suite of enzymes to mitigate cellular damage from reactive oxygen species (ROS). Here, we review the diversity and distribution of ROS enzymatic defense mechanisms across the domain Bacteria, using both peer-reviewed literature and publicly available genome databases. We describe the specific strategies used by well-characterized organisms in order to highlight differences in oxidative stress responses between aerobic, facultatively anaerobic, and anaerobic lifestyles. We present evidence from genome minimization experiments to suggest that ROS defenses are obligately required for life. This review clarifies the variability in ROS defenses across Bacteria, including the novel diversity found in currently uncharacterized Candidate Phyla.
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