Article
Environmental Sciences
Jie Gu, Kongdong Li, Hong Lin, Yanwei Wang, Yang Zhou, Dongfeng Chen, Xin Gu, Haifeng Shi
Summary: Cadmium exposure inhibits the expression of TNF-alpha and IFN-gamma, and may affect the NF kappa B signaling pathway in mouse spleen tissues. By promoting autophagy-lysosomal degradation of TLR9, cadmium suppresses immune response under ConA activation condition.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Svetlana Sharifulina
Summary: HDAC and HAT play crucial roles in regulating cell functions through acetylating/deacetylating histones and non-histone proteins, impacting cell survival, death, and other processes. The effects of stroke on non-histone protein acetylation/deacetylation in brain cells are still poorly understood, but HDAC inhibitors have shown promise in protecting the brain from ischemic damage. The roles of different HDAC isoforms in brain cell survival and death after stroke remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Farhan Ullah, Qiutao Xu, Yu Zhao, Dao-Xiu Zhou
Summary: HDA710 plays a role in regulating salt and ABA stress-responsive genes in rice by altering H4 acetylation levels in their promoters, with knockout and overexpression of HDA710 resulting in opposite stress tolerance phenotypes.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Environmental Sciences
Wei Yuan, Zhaopeng Xu, You Wei, Wuting Lu, Kun Jia, Jing Guo, Yunlong Meng, Yuyang Peng, Zhanfeng Wu, Zulin Zhu, Fei Ma, Fenghua Wei, Guiyou Tian, Zhou Liu, Qiang Luo, Jinze Ma, Hao Zhang, Wenjin Liu, Huiqiang Lu
Summary: Exposure to Sulfometuron methyl (SM) led to toxicity in zebrafish early developmental stages, affecting development, immune system, locomotor behavior, oxidative stress, and cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biology
Alicia Tapias, David Lazaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Summary: The study reveals the importance of TRRAP for neuroprotection and the network connecting TRRAP, HAT, and SP1 in regulating microtubule dynamics.
Article
Oncology
Li-Xia Peng, Ming-Dian Wang, Ping Xie, Jun-Ping Yang, Rui Sun, Li-Sheng Zheng, Yan Mei, Dong-Fang Meng, Xing-Si Peng, Yan-Hong Lang, Yuan-Yuan Qiang, Chang-Zhi Li, Liang Xu, Zhi-Jie Liu, Ling-Ling Guo, De-Huan Xie, Di-Tian Shu, Si-Ting Lin, Fei-Fei Luo, Bi-Jun Huang, Chao-Nan Qian
Summary: Nasopharyngeal carcinoma (NPC) originates in the nasopharyngeal epithelium and is known for its high metastatic rate. The study found elevated expression of LACTB in tumor tissues of NPC, which correlated with poorer patient survival. The role of LACTB in promoting NPC metastasis is dependent on the activation of ERBB3/EGFR-ERK signaling pathway.
Article
Biochemistry & Molecular Biology
Chia-Chun Chang, Yi-Chou Liu, Chih-Hsuan Lin, Yi-Chun Liao
Summary: This study elucidated the mechanism by which EGFR signaling upregulates CTEN gene expression through modulating chromatin structure and histone acetylation status within the CTEN promoter.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Saadia Khilji, Yuan Li, Jihong Chen, Qiao Li
Summary: Bexarotene, an agonist of retinoid X receptor, plays a crucial role in promoting myoblast differentiation. Integration of RNA-seq and ChIP-seq data helps decipher the molecular regulation of rexinoid signaling in myogenic differentiation. These datasets provide strategies and a framework for future research.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shunhao Zhang, Sining Duan, Zhuojun Xie, Wanlin Bao, Bo Xu, Wenbin Yang, Lingyun Zhou
Summary: The NRF2/KEAP1 signaling pathway plays a key role in cellular physiology by protecting cells from stress conditions. However, recent studies have shown that this pathway may have oncogenic effects and contribute to therapy resistance. This article investigates the role of epigenetic modifications in regulating the NRF2/KEAP1 signaling pathway and its impact on cancer development, and explores the potential of targeting epigenetic changes as therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lele Song, Xinyi Yao, Hangpeng Li, Bo Peng, Alan P. Boka, Yiman Liu, Guochao Chen, Zhenyang Liu, Kaeli M. Mathias, Lingbo Xia, Qinglan Li, Mustafa Mir, Yuanyuan Li, Haitao Li, Liling Wan
Summary: Growing evidence suggests the presence of transcriptional condensates on chromatin, but their formation mechanisms and functional significance are still unclear. This study reveals that mutations in the histone acetylation reader ENL can lead to aberrant condensate formation, which drives oncogenic gene activation in human cancer.
Article
Orthopedics
S. Monteagudo, F. M. F. Cornelis, X. Wang, A. de Roover, T. Peeters, J. Quintiens, A. Sermon, R. C. de Almeida, I Meulenbelt, R. J. Lories
Summary: ANP32A is identified as a novel repressor of Wnt signaling in articular cartilage, and its loss leads to hyper-activation of Wnt signaling. ANP32A inhibits target gene expression by histone acetylation masking. The study also reveals the involvement of ANP32A in cardiac hypertrophy. These findings have significant implications for understanding the pathogenesis of osteoarthritis and cardiac diseases.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Editorial Material
Endocrinology & Metabolism
Natalie Niemi
Summary: Previous studies suggested that acetylation of mitochondrial proteins occurs non-enzymatically, but a new research challenges this notion by demonstrating the involvement of a histone acetyltransferase in enhancing mitochondrial metabolism through acetylating a complex IV assembly factor.
Review
Cell Biology
Clovis H. T. Seumen, Tanja M. Grimm, Christof R. Hauck
Summary: Toll-like receptors (TLRs) play a crucial role in immune response, but exaggerated activation can lead to inflammatory diseases. This review discusses the impact of protein phosphorylation on TLR signaling, highlighting the role of phosphatases as negative regulators. Understanding phosphatase-mediated regulation could offer new approaches to modulate immune signaling.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Engineering, Environmental
Liang Tang, Wenhui Qiu, Shuwen Zhang, Jiazhen Wang, Xin Yang, Bentuo Xu, Jason T. Magnuson, Elvis Genbo Xu, Minghong Wu, Chunmiao Zheng
Summary: Through experiments, it was found that perfluorobutanesulfonic acid (PFBA), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) with different carbon chain lengths significantly reduced the antibacterial ability of zebrafish during the early-life stage, suppressed the innate and adaptive immune systems, and showed a positive correlation with carbon chain length. It was also discovered that PFASs exerted immunomodulatory effects by activating downstream genes of the Toll-like receptor, and inhibiting the Toll-like receptor pathway could alleviate the immunotoxicity of PFASs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kwon Young Chou, Jun-Yeong Lee, Kee-Beom Kim, Eunjeong Kim, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: The budding yeast Saccharomyces cerevisiae is a widely used model system for studying histone modifications and chromatin states. Recent advances in biotechnology have allowed for the detection and quantification of protein post-translational modifications, leading to the identification of new modification sites in histones. Understanding the cellular functions of these new histone markers is crucial for unraveling epigenetic mechanisms and their impact on biological processes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Fisheries
Guanghua Xiong, Yunyun Deng, Zigang Cao, Xinjun Liao, Jun'e Zhang, Huiqiang Lu
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Fisheries
Bo Cheng, Hua Zhang, Kun Jia, Enchao Li, Shouhua Zhang, Huiyun Yu, Zigang Cao, Guanghua Xiong, Chengyu Hu, Huiqiang Lu
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xinjun Liao, Xiaowen Shi, Hongmei Hu, Xiangju Han, Kai Jiang, Yong Liu, Guanghua Xiong
Summary: This study investigated the differences in nutritional components and muscle characteristics of the Chinese Taihe Black-bone silky fowl (TBsf) under different diets. Metabolic analysis revealed differential metabolites between TBsf-ncf and BF-gsc groups, as well as TBsf-ncf and TBsf-bpf groups. Integrated network analysis identified significant metabolic biomarkers in TBsf. These findings provide valuable information for the production and development of TBsf, enhancing its economic value.