Article
Rheumatology
Pernille Steen Pettersen, Tuhina Neogi, Karin Magnusson, Alexander Mathiessen, Hilde Berner Hammer, Till Uhlig, Tore K. Kvien, Ida K. Haugen
Summary: The pathologies and symptom duration of hand osteoarthritis (OA) are related to central sensitization, with erosive hand OA potentially causing greater central sensitization. Structural and inflammatory severity are not associated with central sensitization, while symptom duration does not contribute to central sensitization.
Article
Cell Biology
Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka, Norikazu Kiguchi
Summary: The study focuses on investigating the sex-dependent roles of microglia in pain hypersensitivity, highlighting the importance of understanding the molecular aspects of spinal microglia regulation in pain. The results showed that chemogenetic activation of spinal microglia resulted in pain hypersensitivity in male mice, with sex differences observed in the upregulation of reactive microglia-dominant molecules and response to microglia depletion using pexidartinib.
Article
Plant Sciences
Rafaela Cunha Matosinhos, Juliana Pantaleao Bezerra, Camila Helena Barros, Ana Catharina Fernandes Pereira Ferreira Bernardes, Grazielle Brandao Coelho, Marcela Carolina de Paula Michel Araujo, Rodrigo Dian de Oliveira Aguiar Soares, Daniela Sachs, Denia Antunes Saude-Guimaraes
Summary: The study demonstrated that coffee extracts prepared with water at 98 degrees C were more effective in exerting anti-gouty and anti-inflammatory activities. Caffeic and chlorogenic acids were found to decrease hypernociception, inhibit neutrophil migration, and reduce pro-inflammatory cytokines concentration, suggesting coffee as a potential candidate for acute gout therapy studies.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeng-Chang Chen, Cheng-Chi Chan, Nai-Chun Ting, Ming-Ling Kuo
Summary: The study found that neonatal exposure to allergens can trigger asthma-related immune responses and exacerbate asthma symptoms in adulthood. Gender differences play a significant role in asthma development, with females being more susceptible to asthma-related stimuli.
Article
Plant Sciences
Maria Graca Miguel, Carina Isabel da Silva, Luana Farah, Fernao Castro Braga, Ana Cristina Figueiredo
Summary: This study evaluated the effect of 20 essential oils on the release of CCL2 and TNF-alpha by LPS-stimulated THP-1 cells. Some essential oils showed toxicity to cells, while T. capitata and L. luisieri essential oils exhibited good inhibitory effects on TNF-alpha release.
Article
Dermatology
Francesco Bellinato, Paolo Gisondi, Angelo Fassio, Giampiero Girolomoni
Summary: This study investigated central sensitization in patients with chronic plaque psoriasis. The results showed a higher proportion of central sensitization in patients with both psoriasis and psoriatic arthritis. Central sensitization was found to be associated with quality of life, disease severity, and psychological factors.
DERMATOLOGY AND THERAPY
(2023)
Article
Immunology
Fausto Salaffi, Marina Carotti, Sonia Farah, Luca Ceccarelli, Andrea Giovagnoni, Marco Di Carlo
Summary: In patients with active rheumatoid arthritis, treatment with JAKis for 4 weeks has a positive effect on central sensitization and pain catastrophizing, leading to improvement in disease activity. There is a correlation between central sensitization, pain catastrophizing, and improvement in disease activity.
INFLAMMOPHARMACOLOGY
(2022)
Review
Neurosciences
Meiling Bai, Ruize Sun, Bin Cao, Juan Feng, Jue Wang
Summary: Ischemic stroke is a leading cause of death worldwide and the most common cause of disability in Western countries. Inflammation plays a vital role in the development and progression of ischemic stroke, and peripheral blood immune cells, particularly monocytes, are involved in the immune cascade after stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Meiling Liu, Kang Wu, Jinduan Lin, Qingqiang Xie, Yuan Liu, Yin Huang, Jun Zeng, Zhaogang Yang, Yifan Wang, Shiyan Dong, Weiye Deng, Mingming Yang, Song Wu, Wen Jiang, Xuefeng Li
Summary: COPD is a global disease with complex causes, where the immune system plays a key role in inflammation. IL-17A is involved in the development of COPD through multiple signaling pathways, making it a potential novel therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Paraskevi Bilika, Jo Nijs, Emmanouil Fandridis, Zacharias Dimitriadis, Nikolaos Strimpakos, Eleni Kapreli
Summary: This study examined the associations between central sensitization and various factors in patients with chronic shoulder pain. The results showed that catastrophizing, depression, and functionality were predictive factors for central sensitization symptoms. Patients classified as centrally sensitized had worse functionality, psychological factors, and pain intensity.
Review
Immunology
Mahvash Sadeghi, Sajad Dehnavi, Ali Asadirad, Suowen Xu, Muhammed Majeed, Tannaz Jamialahmadi, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Chemokines are cytokines that regulate chemotaxis and leukocyte migration, as well as angiogenesis and hemostasis. Curcumin has various pharmacological actions and modulates chemokines and chemokine receptors. This review focuses on the molecular mechanisms of curcumin's effects on chemoattractant cytokines and its regulatory effects on inflammatory conditions and other diseases.
INFLAMMOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Elena R. Serrano-Ibanez, Rosa Esteve, Carmen Ramirez-Maestre, Gema T. Ruiz-Parraga, Alicia E. Lopez-Martinez
Summary: The COVID-19 crisis has been found to be associated with changes in daily routines, pain intensity, emotional distress, and sensitization scores. There were correlations between emotional distress, sensitization, and pain intensity. Significant predictors of emotional distress included age, difficulty in receiving medical care, changes in daily routines, and diminished social support. Emotional distress did not mediate the association between sensitization and pain intensity.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Soo Youn Song, Ye Won Jung, WonKyo Shin, Mia Park, Geon Woo Lee, Soohwa Jeong, Sukjeong An, Kyoungmin Kim, Young Bok Ko, Ki Hwan Lee, Byung Hun Kang, Mina Lee, Heon Jong Yoo
Summary: Endometriosis, a common gynecologic disease, often leads to various pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. Inflammatory responses, nervous system sensitization, and altered distribution of nerve fibers may contribute to chronic pain in these patients. Understanding these mechanisms is crucial in guiding treatment decisions for endometriosis-related pain symptoms.
Article
Medicine, General & Internal
Bjorn Gerdle, Karin Wahlen, Torsten Gordh, Emmanuel Backryd, Anders Carlsson, Bijar Ghafouri
Summary: This study reveals that plasma proteins obtained from proteomics and targeted inflammatory panels can differentiate chronic widespread pain/fibromyalgia patients from controls. The analysis of biological processes shows the relevance of acute phase response, complement activation, and innate immune response to pain symptoms. Besides cytokines/chemokines, other components of the immune and inflammation systems also play a significant role.
Review
Biochemistry & Molecular Biology
Martina Ferrillo, Amerigo Giudice, Nicola Marotta, Francesco Fortunato, Daniela Di Venere, Antonio Ammendolia, Pietro Fiore, Alessandro de Sire
Summary: Temporomandibular disorders (TMD) are musculoskeletal diseases affecting the jaw muscles and temporomandibular joints. Chronic TMD can be considered as a condition with chronic primary orofacial pain. The main objectives of treatment are to decrease pain, improve jaw joint function, and reduce muscle spasms and pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)