Article
Cell Biology
Hyosuk Kim, Yeongji Jang, Eun Hye Kim, Hochung Jang, Haeun Cho, Geonhee Han, Hyun Kyu Song, Sun Hwa Kim, Yoosoo Yang
Summary: Exosomes derived from bovine colostrum have been found to promote hair growth and regulate the hair cycle, making it a promising therapy for hair loss. This method is comparable to minoxidil treatment but without adverse effects, and can maintain its efficacy after freeze-drying and resuspension.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guanning Wei, Hongmei Sun, Haijun Wei, Tao Qin, Yifeng Yang, Xiaohong Xu, Shoujing Zhao
Summary: Dermal papilla cells from different species exhibit distinct growth patterns in vitro, suggesting a relationship between self-aggregation behavior and culture conditions. Using sika deer dermal papilla cells, it was demonstrated that the culture condition plays a crucial role in determining the growth pattern and hair inducing capability of dermal papilla cells. The transition between 2D and 3D growth patterns in sika deer dermal papilla cells highlights the potential regulating genes and pathways involved in the recovery of 3D pattern and hair inducing capability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Masahiro Fukuyama, Aki Tsukashima, Momoko Kimishima, Yoshimi Yamazaki, Hideyuki Okano, Manabu Ohyama
Summary: This study attempted to reproduce the anatomical relationship between the epithelial main body and the dermal papilla within hair follicles in vitro and evaluated how follicle characteristics were reproduced in constructs. Using hiPSC-derived cell composites, the study showed promising potential for regenerating hair follicle equivalents with in vitro hair inductive capacity, reducing the reliance on human tissue-derived trichogenic cell subsets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Zhen Liu, Junfei Huang, Deni Kang, Yi Zhou, Lijuan Du, Qian Qu, Jin Wang, Lihong Wen, Danlan Fu, Zhiqi Hu, Yong Miao
Summary: An optimized 3-D co-culture system was developed to restore the hair-inductive characteristics of human dermal papilla cells (hDPCs) by mimicking the in-vivo microenvironment. The study showed that Matrigel-encapsulated hDPCs spontaneously formed hDPC aggregates (hDPAs) with better activity, higher proliferation rates, and less apoptosis and hypoxia. The co-culture with hair matrix cells and dermal sheath cup cells further enhanced the expression of hair regeneration-related genes and improved mature hair follicle induction.
ACTA BIOMATERIALIA
(2023)
Article
Multidisciplinary Sciences
Carla M. Abreu, Mariana T. Cerqueira, Rogerio P. Pirraco, Luca Gasperini, Rui L. Reis, Alexandra P. Marques
Summary: The conditioned medium from interfollicular keratinocytes (KCs-CM) has been shown to improve the hair inductive ability of DP cells, with significant effects on DP cell growth and restoration of activity. Additionally, DP cells cultured with KCs-CM in spheroids demonstrated superior activity and supported the formation of hair follicle- and sebaceous gland-like structures in mice when co-grafted with human keratinocytes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jiali Li, Bohao Zhao, Shuyu Yao, Yingying Dai, Xiyu Zhang, Naisu Yang, Zhiyuan Bao, Jiawei Cai, Yang Chen, Xinsheng Wu
Summary: This study found that exosomes derived from dermal papilla cells regulate hair follicle stem cell proliferation by stimulating LEF1, providing new insights into the regulatory mechanisms of hair follicle growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Yuting Zhang, Chunya Ni, Yan Huang, Yulong Tang, Kai Yang, Xiangguang Shi, Yue Zhang, Zheng Li, Ji'an Wang, Yifei Zhu, Haiyang Li, Yanyun Ma, Jinran Lin, Jiucun Wang, Qingmei Liu, Wenyu Wu
Summary: Research has shown that resveratrol (RSV) can significantly promote hair growth in mice and delay human hair follicles entering the catagen phase. Additionally, in vitro experiments have demonstrated that RSV promotes the proliferation of human dermal papilla cells and protects them from oxidative damage.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Dermatology
Mayumi Ikeda, Shigeharu Yabe, Masahiro Kiso, Naoko Ishiguro, Yuichiro Tsunemi, Hitoshi Okochi
Summary: This study evaluated the function of TERT and BMI1 in human DPCs. The results showed that overexpression of both TERT and BMI1 extends the lifespan of human DPCs and improves their hair inducing ability on mouse hair follicles.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fan Li, Hongli Liu, Xiaojing Wu, Zhicheng Song, Haojia Tang, Maohua Gong, Lei Liu, Fuchang Li
Summary: Dermal papilla cells (DPCs) play important roles in hair growth regulation, but strategies to regrow hair are lacking. This study found that copper depletion severely impaired the key marker of hair growth in DPCs by increasing excessive ROS production, leading to decreased ATP production, mitochondrial membrane potential depolarization, and increased total cellular ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Bohao Zhao, Jiali Li, Ming Liu, Shuaishuai Hu, Naisu Yang, Shuang Liang, Xiyu Zhang, Yingying Dai, Zhiyuan Bao, Yang Chen, Xinsheng Wu
Summary: The study reveals the important role of lncRNA2919 in the cyclic regeneration of hair follicles, as it regulates the expression of related genes and affects cell proliferation and apoptosis processes, thus influencing the growth and development of hair follicles.
Article
Pharmacology & Pharmacy
Jiyu Hyun, Jisoo Im, Sung-Won Kim, Han Young Kim, Inwoo Seo, Suk Ho Bhang
Summary: The use of Morus alba root extract promotes hair growth by activating beta-catenin in hair follicle dermal papilla cells, leading to the induction of the anagen phase. Additionally, the extract enhances growth factor secretion and shows no cytotoxic effects on the cells. Overall, Morus alba root extract demonstrates potential in transitioning hair follicles from the telogen phase to the anagen phase.
Article
Cell Biology
Carla M. Abreu, Rui L. Reis, Alexandra P. Marques
Summary: The study showed that under 5% oxygen levels, human dermal papilla cells and melanocytes exhibited improved physiological state and phenotype, with interactions between them enhancing hair growth and pigmentation. The findings provide important insights for research on hair regeneration.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Aprill Kee Oliva, Meriem Bejaoui, Atsushi Hirano, Takashi Arimura, Tran Ngoc Linh, Eriko Uchiage, Sachiko Nukaga, Kenichi Tominaga, Hiroyuki Nozaki, Hiroko Isoda
Summary: This study evaluated the hair growth promoting effect of the green alga Botryococcus terribilis and discovered its ability to stimulate various pathways and genes, influence collagen and keratin synthesis, and reduce inflammation. Additionally, a novel compound was isolated and found to have promising effects on hair growth.
Article
Cell Biology
Xiaolan Zhang, Pengjia Bao, Qingbo Zheng, Min Chu, Chunnian Liang, Xian Guo, Xiaoyun Wu, Meilan He, Chengfang Pei, Ping Yan
Summary: This study analyzed the interaction between dermal papilla cells (DPCs) and epidermal hair matrix cells (HMCs) in yak, revealing significant molecular differences between these two cell types. DPCs showed a higher expression of genes related to hair follicle development, while HMCs showed enrichment of genes associated with microbiota and immunity. Several microRNAs associated with hair follicle development were found to be differentially expressed. These findings contribute to our understanding of the interaction and cellular communication between DPCs and HMCs during hair follicle development in yak.
Article
Biochemistry & Molecular Biology
Justin J. Y. Tan, Duc-Viet Nguyen, John E. Common, Chunyong Wu, Paul C. L. Ho, Lifeng Kang
Summary: Hair follicle morphogenesis relies on the interaction between epidermal stem cells and specialized mesenchymal cells. Previous studies have shown that co-culture with keratinocytes can maintain the characteristics of the dermal papilla, but challenges exist due to poor intercellular adherence. Developing long-term 3D co-culture models is difficult because of keratinocytes' exfoliative behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Vidya Sankarapandian, Balu Alagar Venmathi Maran, Ramya Lakshmi Rajendran, Manasi P. Jogalekar, Sridharan Gurunagarajan, Rajapandiyan Krishnamoorthy, Prakash Gangadaran, Byeong-Cheol Ahn
Summary: Probiotics play a significant role in the prevention and treatment of cancer by enhancing the epithelial barrier and stimulating the production of anti-inflammatory, antioxidant, and anticarcinogenic compounds.
Review
Medicine, Research & Experimental
Anand Krishnan, Prakash Gangadaran, Vivek P. Chavda, Manasi P. Jogalekar, Ramesh Muthusamy, Disha Valu, Chithravel Vadivalagan, Prasanna Ramani, Alexey Laishevtcev, Naresh Kumar Katari, Byeong-Cheol Ahn
Summary: COVID-19, caused by the spread of SARS-CoV-2, has impacted society greatly, with misdiagnoses and inaccurate test results being common. A more specific, selective, and reliable diagnostic tool is needed, and convalescent serum-derived exosomes show potential in this regard.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Balu Alagar Venmathi Maran, Mohammad Iqbal, Prakash Gangadaran, Byeong-Cheol Ahn, Pasupuleti Visweswara Rao, Muhammad Dawood Shah
Summary: Medicinal plants, such as Andrographis paniculata, Bauhinia purpurea, Commelina nudiflora, Dillenia suffruticosa, Elaeis guineensis, Lygodium microphyllum, and Nephrolepis biserrata, have been reported to have hepatoprotective properties due to their phytochemical composition. These plants contain various compounds, including alkaloids, saponins, flavonoids, tannins, terpenoids, steroids, polyphenols, and diterpenoid lactones, which contribute to their antioxidant, anti-inflammatory, immunomodulatory, and hepatoprotective effects.
Article
Oncology
Ji Min Oh, Ramya Lakshmi Rajendran, Prakash Gangadaran, Chae Moon Hong, Ju Hye Jeong, Jaetae Lee, Byeong-Cheol Ahn
Summary: In this study, the researchers found that reversing iodine non-avid thyroid cancers to iodine avid cancers can make the cancers sensitive to radioactive-iodine therapy again. They demonstrated that GLI1 knockdown increased expression of thyroid-specific proteins, restoring iodine avidity and improving the efficacy of radioactive-iodine therapy. Targeting GLI1 could be a potential strategy for redifferentiation in dedifferentiated thyroid cancers.
Article
Pharmacology & Pharmacy
Talagavadi Channaiah Anudeep, Madhan Jeyaraman, Sathish Muthu, Ramya Lakshmi Rajendran, Prakash Gangadaran, Prabhu Chandra Mishra, Shilpa Sharma, Saurabh Kumar Jha, Byeong-Cheol Ahn
Summary: Alopecia, including scarring and non-scarring types, is a common diagnosis in clinical practice. The most prevalent type is non-scarring alopecia, with androgenetic alopecia and alopecia areata being the majority of cases. Traditional treatments have significant downsides, leading to the exploration of regenerative therapies. Growth factor-rich and stem cell-rich treatments have shown potential, but standardization is lacking. Further understanding and standardization of regenerative cellular therapies for hair restoration are needed.
Article
Chemistry, Medicinal
Prakash Gangadaran, Eun Jung Oh, Ramya Lakshmi Rajendran, Hyun Mi Kim, Ji Min Oh, Suin Kwak, Chae Moon Hong, Kang Young Choi, Ho Yun Chung, Byeong-Cheol Ahn
Summary: This study explores the use of human normal fibroblast-derived extracellular vesicles (hNF-EVs) for wound healing. The researchers found that hNF-EVs contain proangiogenic factors and can promote the proliferation and migration of fibroblasts and endothelial cells, as well as accelerate wound healing in mice. The delivery of hNF-EVs without the need for scaffolds and invasiveness offers a novel approach for efficient wound healing.
Review
Chemistry, Medicinal
Gollahalli Shivashankar Prajwal, Naveen Jeyaraman, Krishna Kanth, Madhan Jeyaraman, Sathish Muthu, Sree Naga Sowndary Rajendran, Ramya Lakshmi Rajendran, Manish Khanna, Eun Jung Oh, Kang Young Choi, Ho Yun Chung, Byeong-Cheol Ahn, Prakash Gangadaran
Summary: Tissue engineering and regenerative medicine provide a new approach for treating musculoskeletal diseases, utilizing MSCs and growth factors to improve the regenerative environment. However, the selection of MSCs source and the long-term and short-term effects of MSCs treatment remain uncertain.
Article
Biology
Luciano C. Ramires, Madhan Jeyaraman, Sathish Muthu, Navaladi A. Shankar, Gabriel Silva Santos, Lucas Furtado da Fonseca, Jose Fabio Lana, Ramya Lakshmi Rajendran, Prakash Gangadaran, Manasi P. Jogalekar, Alfredo A. Cardoso, Alex Eickhoff
Summary: Orthobiologics, including various cell populations, cytokines, and growth factors, show potential in promoting tissue regeneration and homeostasis in Achilles tendinopathy, a condition characterized by disrupted healing responses, persistent inflammation, and catabolic reactions. Further studies and clinical trials are needed to validate the clinical utility and efficacy of these therapeutic strategies in the management of tendinopathies.
Article
Cell Biology
Ramya Lakshmi Rajendran, Prakash Gangadaran, Mi Hee Kwack, Ji Min Oh, Chae Moon Hong, Madhan Jeyaraman, Young Kwan Sung, Jaetae Lee, Byeong-Cheol Ahn
Summary: The study suggests that engineered nanovesicles (eNVs) have therapeutic potential for alopecia, as they can enhance the proliferation and migration of hair follicle cells and increase the size of human hair follicles.
Review
Biotechnology & Applied Microbiology
Ragunanthan Narayanaswamy, Bishnu Prasad Patro, Naveen Jeyaraman, Prakash Gangadaran, Ramya Lakshmi Rajendran, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Prasanna Ramani, Byeong-Cheol Ahn
Summary: Various forms of platelet concentrates have evolved over the past few decades, with newer generation products such as leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) showing superior biological properties in musculoskeletal regeneration compared to the first-generation concentrates. These newer platelet concentrates have a complete matrix of physiological fibrin and facilitate intercellular signaling and migration, promoting angiogenic, chondrogenic, and osteogenic activities. A-PRF, with higher leukocyte inclusion, also possesses antimicrobial activity and can replicate various physiological and immunological factors of wound healing. Its applications have expanded to include the management of musculoskeletal conditions, reconstructive cosmetic surgery, wound healing in diabetic patients, and maxillofacial surgeries.
BIOENGINEERING-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Bushu Harna, Vijay Gupta, Shivali Arya, Naveen Jeyaraman, Ramya Lakshmi Rajendran, Madhan Jeyaraman, Prakash Gangadaran, Manish Khanna, Chae Moon Hong, Byeong-Cheol Ahn
Summary: Adhesive capsulitis shoulder is a common problem, and this study evaluated the efficacy of intra-articular injections of platelet-rich plasma (PRP) in the treatment. The results showed that PRP injections improved clinical and functional outcomes in patients with adhesive capsulitis shoulder, and no major side effects were observed.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Prakash Gangadaran, Eun Jung Oh, Ramya Lakshmi Rajendran, Ji Min Oh, Hyun Mi Kim, Suin Kwak, Ho Yun Chung, Jaetae Lee, Byeong-Cheol Ahn, Chae Moon Hong
Summary: Cultured MSCs exhibit different effects on their secretomes depending on whether they are grown as 2D monolayers or 3D spheroids. The secretomes of 3D-MSCs contain higher levels of proangiogenic factors compared to 2D-MCs. The secretomes of 3D-MSCs promote proliferation, migration, and tube formation of ECs, and show enhanced wound healing in a burn injury mouse model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Vidya Sankarapandian, Kirubakaran Nitharsan, Kavitha Parangusadoss, Prakash Gangadaran, Prasanna Ramani, Balu Alagar Venmathi Maran, Manasi P. P. Jogalekar
Summary: The study aimed to develop prebiotic products from Spirulina and analyzed the biological properties. Various value-added products were prepared to meet the nutritional needs of vulnerable populations.
Article
Biotechnology & Applied Microbiology
Sathish Muthu, Madhan Jeyaraman, Moinuddin Basha Kotner, Naveen Jeyaraman, Ramya Lakshmi Rajendran, Shilpa Sharma, Manish Khanna, Sree Naga Sowndary Rajendran, Ji Min Oh, Prakash Gangadaran, Byeong-Cheol Ahn
Summary: Stem cells have the ability to self-renew and differentiate into various cell lineages, making them valuable for regenerative therapies. Stem cell therapy is a rapidly advancing branch of medicine that offers potential treatments for severe diseases. The development of international standards for advanced therapeutic medicinal products aims to facilitate global information exchange.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Madhan Jeyaraman, Shiva Kumar Bingi, Sathish Muthu, Naveen Jeyaraman, Rathinavelpandian Perunchezhian Packkyarathinam, Rajni Ranjan, Shilpa Sharma, Saurabh Kumar Jha, Manish Khanna, Sree Naga Sowndary Rajendran, Ramya Lakshmi Rajendran, Prakash Gangadaran
Summary: Human bone marrow is a promising source of mesenchymal stromal cells (MSCs) for regenerative procedures involving cartilage and bone. However, the low proportion of MSCs in the bone marrow requires careful harvesting and processing techniques. There is currently a lack of consensus regarding the variables in the harvesting and processing technique of bone marrow aspiration concentrate (BMAC) and their impact on MSC yield.
BIOENGINEERING-BASEL
(2022)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
