Article
Gastroenterology & Hepatology
Xiaoting Huang, Leyang Xiang, Wei Liu, Mingyi Li, Anbang Ren, Zide Chen, Chu Zheng, Chen Chengcong, Jinquan Liu, Yawei Yuan
Summary: The study revealed that overexpression of DMBX1 in HCC is associated with metastasis and poor prognosis, suggesting that DMBX1 may be a therapeutic target for HCC.
ANNALS OF HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Basma El-Helkan, Manal Emam, Marwa Mohanad, Shadia Fathy, Abdel Rahman Zekri, Ola S. Ahmed
Summary: This study evaluated a panel of long non-coding RNAs and two mRNAs as prognostic biomarkers for breast cancer. The results showed that the expression levels of some lncRNAs and mRNAs changed significantly in breast cancer patients, and they may serve as potential prognostic markers for breast cancer.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Vaibhavi Joshi, Sunil R. Lakhani, Amy E. McCart E. Reed
Summary: N-myc downregulated gene-1 (NDRG1) has been reported to have diverse roles in cancer, serving as either a metastasis suppressor, a biomarker of poor outcome, or a facilitator of disease progression. Its functions in cancer are context-dependent and pleiotropic, with its effects in breast cancer varying depending on post-translational modifications and subcellular localization.
Article
Oncology
Weidan Ji, Zhangxiao Peng, Bin Sun, Lei Chen, Qin Zhang, Minggao Guo, Changqing Su
Summary: The study confirmed that high expression of LpCat1 in HCC cells promoted cancer cell invasion, playing a crucial role in the progression and metastasis of HCC by interacting with STAT1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yingying Tian, Beibei Ma, Xinyue Zhao, Shiqiu Tian, Yilin Li, Hailuan Pei, Shangyue Yu, Chuang Liu, Zhaozhou Lin, Zeping Zuo, Zhibin Wang
Summary: DL extracted from Aucklandia lappa Decne. has been found to possess significant anticancer effects by suppressing the proliferation and migration of hepatocellular carcinoma (HCC) cells and inducing cell cycle arrest and apoptosis. It shows potential as a promising drug for the treatment of HCC.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Noriko Yamada, Rie Matsushima-Nishiwaki, Kaido Kobayashi, Shota Takahata, Hidenori Toyoda, Takashi Kumada, Osamu Kozawa
Summary: Heat shock proteins (HSPs) play a crucial role in proteostasis, with small HSPs like HSPB1, HSPB6, and HSPB8 showing both protective and suppressive effects in hepatocellular carcinoma (HCC). Phosphorylation of these small HSPs may contribute to the inhibition of HCC progression.
CURRENT MOLECULAR MEDICINE
(2021)
Article
Immunology
Mei-Ling Dong, Xu Wen, Xin He, Ji-Hua Ren, Hai-Bo Yu, Yi-Ping Qin, Zhen Yang, Min-Li Yang, Chong-Yang Zhou, Hui Zhang, Sheng-Tao Cheng, Juan Chen
Summary: The study found that DDX17 plays an important role in the replication of HBV and the metastasis of HBV-related HCC. By promoting HBV replication and transcription as well as HBx-mediated HCC metastasis, DDX17 has a promotive effect on the development of HBV and HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qian Yun Ge, Jin Chen, Gan Xun Li, Xiao Long Tan, Jia Song, Deng Ning, Jie Mo, Peng Cheng Du, Qiu Meng Liu, Hui Fang Liang, Ze Yang Ding, Xue Wu Zhang, Bi Xiang Zhang
Summary: GRAMD4 inhibits the migration and metastasis of HCC by promoting the degradation of TAK1, which leads to the inactivation of MAPK and NF-kappa B signalling pathways.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Chengfei Zhang, Xiaoming Wang, Dan Fang, Ping Xu, Xiao Mo, Chao Hu, Alaa Abdelatty, Mei Wang, Haojun Xu, Qi Sun, Guoren Zhou, Junjun She, Jinglin Xia, Kam Man Hui, Hongping Xia
Summary: The study revealed that STK39 is highly overexpressed in clinical HCC tissues, induced by transcription factor SP1, and correlated with poor patient survival. Overexpression of STK39 promoted HCC cell proliferation, migration, and invasion, while depletion of STK39 attenuated growth and metastasis. Knockdown of STK39 induced HCC cell cycle arrest and apoptosis.
Article
Cell Biology
Danlei Chen, Yan Yan, Xinyi Wang, Suzhi Li, Yan Liu, Dandan Yu, Yongjing He, Ruiqing Deng, Yakun Liu, Mei Xu, Jia Luo, Hongjun Gao, Siying Wang
Summary: This study found that chronic alcohol exposure promotes the progression of hepatocellular carcinoma (HCC), with miR-22-3p and TET2 playing important roles in this process, affecting the stemness, tumor growth, and metastasis of HCC cells.β-catenin was identified as an upstream activator of miR-22-3p, indicating the involvement of the beta-catenin/miR-22-3p/TET2 regulatory axis in alcohol-induced HCC malignancy.
Article
Biochemistry & Molecular Biology
Lu Bai, Zhao-Xu Yang, Peng-Fei Ma, Jian-Shan Liu, De-Sheng Wang, Heng-Chao Yu
Summary: SLC25A51 is overexpressed in hepatocellular carcinoma (HCC) and correlates with clinicopathological characteristics and poor survival in HCC patients. Its overexpression promotes the growth and metastasis of HCC cells through reprogramming glucose metabolism.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Xiao Zhao, Des R. Richardson
Summary: Breast cancer is the leading cause of cancer death in women, and there are different clinical subtypes based on hormone receptor and HER2 status. Targeted therapies exist for ER-α positive and HER2 overexpressing tumors, but resistance and metastasis remain problems, while TNBC lacks suitable targets.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biology
Sofia Lage-Vickers, Juan Bizzotto, Maria Pia Valacco, Pablo Sanchis, Sergio Nemirovsky, Estefania Labanca, Carlos Scorticati, Osvaldo Mazza, Antonina Mitrofanova, Nora Navone, Elba Vazquez, Javier Cotignola, Geraldine Gueron
Summary: This study identifies high YWHAZ and NDRG1 expression as molecular biomarkers associated with poor prognosis in prostate cancer patients, defining two subgroups with high and intermediate risk of disease progression. YWHAZ outperforms Gleason score in predicting aggressiveness of prostate cancer beyond 60 months post-diagnosis.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
Xiaojun Zhang, Feng Gao, Huihan Ai, Shuyue Wang, Zhenbo Song, Lihua Zheng, Guannan Wang, Ying Sun, Yongli Bao
Summary: The study suggests that TSP50 accelerates hepatocyte proliferation by inhibiting the acetylation of G6PD at the K171 site, and promotes the binding of G6PD to SIRT2, mediating cell proliferation and tumor formation. Moreover, TSP50 and G6PD are negatively correlated with the survival of HCC patients according to The Cancer Genome Atlas (TCGA) program.
CELL PROLIFERATION
(2021)
Article
Biology
Rose Hodgson, Xijin Xu, Consuelo Anzilotti, Mukta Deobagkar-Lele, Tanya L. Crockford, Jessica D. Kepple, Eleanor Cawthorne, Aneesha Bhandari, Alberto Cebrian-Serrano, Martin J. Wilcock, Benjamin Davies, Richard J. Cornall, Katherine R. Bull
Summary: NDRG1 plays a role in immune cell suppression, but is functionally redundant in lymphocyte tolerance.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Tao Zeng, Dan Wang, Juan Chen, Ke Chen, Gangfeng Yu, Qiuxu Chen, Yuyang Liu, Shaoyin Yan, Liying Zhu, Huihao Zhou, Ailong Huang, Hua Tang
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Cell Biology
Qiuxu Chen, Dan Wang, Yongguo Li, Shaoying Yan, Hao Dang, Huan Yue, Jiaji Ling, Fengjiao Chen, Yannan Zhao, Luxia Gou, Ping Tang, Ailong Huang, Hua Tang
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Chemistry, Analytical
Fengjiao Chen, Dan Wang, Juan Chen, Jiaji Ling, Huan Yue, Luxia Gou, Hua Tang
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Review
Medicine, General & Internal
Li Pan, Dengshun Lei, Wenbing Wang, Yanqiu Luo, Dan Wang
Article
Oncology
Yan Dong, Dan Wang, Yisheng Luo, Ling Chen, Huili Bai, Yifan Shen, Yangli Zhang, Xueping Chen, Xinliang Su, Jinqiu Zhao, Huandong Liu, Jungao Lu, Zuoyi Yao, Yajing Zhao, Changlong He, Xiaosong Li
Summary: This study identified female sex and tumor diameter <= 1 cm as significant independent predictors of lymph node metastasis in papillary thyroid cancer (PTC). In addition, female sex was identified as a significant independent predictor of lymph node metastasis in PT microcarcinoma. Furthermore, a bilateral tumor was found to be an independent protective factor for lymph node metastasis in PTC.
Article
Public, Environmental & Occupational Health
Ling Chen, Yan Dong, Jiao Li, Jinqiu Zhao, Dan Wang, Li Xu, Yue Wu, Huandong Liu, Jungao Lu, Zuoyi Yao, Xiaosong Li
Summary: The study revealed high prevalence of HPV in Western China with a notable rate of high-risk HPV infections. The distribution of HPV genotypes showed different patterns, with HPV 53 and 6 being the most common viral subtypes in this population, highlighting the need for significant clinical attention.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Biotechnology & Applied Microbiology
Dan Wang, Ling Chen, Chengbi Li, Quanxin Long, Qing Yang, Ailong Huang, Hua Tang
Summary: This study designed a CRISPR/Cas9 delivery system with nanoparticles, which effectively treated hepatitis B virus infection. The results showed that the nanoparticles could inhibit HBV replication and had minimal toxicity and off-target DNA damage in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dan Wang, Fengjiao Chen, Tao Zeng, Qingxia Tang, Bing Chen, Ling Chen, Yan Dong, Xiaosong Li
Summary: Long non-coding RNAs (lncRNAs) play a significant role in various types of human cancers, especially hepatocellular carcinoma (HCC). With further research and the emergence of new molecular targeted therapies, the diagnosis, treatment, and prognosis of HCC can be considerably improved.