期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 244, 期 6, 页码 494-504出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370219830075
关键词
Probiotic; microbiota transplant; microbiome; animal health; disease; dysbiosis
资金
- NIH HHS [T32 OD017863] Funding Source: Medline
Interest in animal microbiomes as therapeutics is rapidly expanding, as techniques to study the microbial world decrease in cost and increase in accessibility and case studies from human medicine receive widespread attention. In this review, we summarize the current state of techniques to modify the microbiome to improve animal health, focusing on applications in domestic pets, farm animals, and in wild settings for conservation. We discuss options for modifying the microbiome, including community-wide changes such as fecal microbiota transplants, prebiotics, probiotics, and antibiotics, and more targeted approaches such as phage therapy and CRISPR-Cas. We conclude that although much remains to be done in untangling the basic biology of microbiome-directed therapies in animals, the rapid progress currently being made in human medicine and the examples to date of application of probiotics and other microbiome-directed therapies in taxa ranging from horses to salamanders to bees suggest excellent prospects for these technologies as they are further developed and as data on both the benefits and risks are carefully and systematically collected.
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