Article
Oncology
Lin Niu, Songhe Yang, Xueying Zhao, Xiaochao Liu, Lina Si, Meng Wei, Lei Liu, Luyang Cheng, Yuebing Qiao, Zhihong Chen
Summary: The study found that sericin could effectively inhibit TNBC cell proliferation, induce cell cycle arrest, and promote cellular apoptosis, primarily by downregulating the PI3K/Akt signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Abdullah Alsrhani, Abozer Y. Elderdery, Badr Alzahrani, Nasser A. N. Alzerwi, Maryam Musleh Althobiti, Musaed Rayzah, Bandar Idrees, Ahmed M. E. Elkhalifa, Suresh K. Subbiah, Pooi Ling Mok
Summary: Breast cancer is a common and increasing malignant disease, and there is a need for better treatment options. Nanotechnology, particularly albumin-based nanoparticles, has potential as a chemotherapy technique for cancer therapy. In this study, albumin visnagin nanoparticles were synthesized and characterized, and their efficacy in suppressing breast cancer cells was examined.
Article
Genetics & Heredity
Ana Paco, Joana Leitao-Castro, Renata Freitas
Summary: HOXB7 is often overexpressed in breast cancer cells and related to poor prognosis. Silencing HOXB7 in TNBC cells can lead to lower migration and invasion rates, as well as changes in CDH1 expression and DNA methylation, suggesting a potential therapeutic target for TNBC treatment.
Article
Biochemistry & Molecular Biology
Zhonghua An, Xuelin Feng, Mengjia Sun, Yifan Wang, Hongbo Wang, Yanling Gong
Summary: The chemical constituents of chamomile essential oil (CEO) were analyzed using gas chromatography-mass spectrometry (GC/MS). CEO is rich in terpenoids, with Caryophyllene, d-Cadinene, and Caryophyllene oxide as the main components. CEO showed significant antitumor activity by inhibiting the proliferation, migration, and invasion of MDA-MB-231 cells through the inhibition of the PI3K/Akt/mTOR signaling pathway.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Oncology
Sophie El Zein, Nadege Gruel, Sylvie Bonvalot, Olivier Mir, Sarah Watson
Summary: This report describes the case of an adult patient with giant unresectable mesenteric cystic lymphangioma, in which activation of the mTOR pathway was identified through molecular characterization. The patient showed significant response to the mTOR inhibitor everolimus, leading to the successful resection of residual tumor lesions after 9 months of treatment. This highlights the potential of mTOR targeting as a neoadjuvant treatment in adult large cystic lymphangioma for complete surgical cure.
Article
Oncology
Masoumeh Hajizadeh, Salar Hafez Ghoran, Hewa Jalal Azeez, Mohammad Ali Hosseinpour Feizi, Esmaeil Babaei
Summary: Gemini Curcumin (Gemini-Cur) is a nanoformulation of curcumin that exhibits significant apoptotic effects on cancer cell lines. This in vitro study demonstrates that Gemini-Cur suppresses the proliferation of MDA-MB-468 breast cancer cells in a time- and dose-dependent manner. The apoptotic effects are mediated through modulation of the expression of Bax, Bcl-2, survivin, and caspase-3.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Bao-Bao Yu, Hao Yuan, Yun-Cong Chen, Dan-Xia Zhou, Zhen-Ji Gan, Jie Wang, Jian-Xin Li, Zhu-Jun Yao
Summary: AA005 shows potential as a future therapeutic agent for TNBC by inhibiting cell growth and activating aerobic glycolysis pathway. AA005 also causes irreversible damage to cell activity and mitochondrial function, leading to cell death. In addition, the in vivo therapeutic efficacy of AA005 has been demonstrated in a mouse model.
Article
Biochemistry & Molecular Biology
Wen-Kuan Huang, Yi Chen, Huafang Su, Tung-Ying Chen, Jiwei Gao, Yaxuan Liu, Chun-Nan Yeh, Shuijie Li
Summary: ARHGAP25 acts as a tumor suppressor in pancreatic adenocarcinoma by inhibiting the AKT/mTOR signaling pathway. Its overexpression can suppress tumor growth by regulating Rac1/PAK1 signaling, as shown in both in vitro and in vivo experiments. Furthermore, ARHGAP25 reduces HIF-1 alpha-mediated glycolysis in PAAD cells, suggesting it as a potential therapeutic target for PAAD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Li Li, Chuting Wang, Zhenpeng Qiu, Dongjie Deng, Xin Chen, Qi Wang, Yan Meng, Baohui Zhang, Guohua Zheng, Junjie Hu
Summary: This study revealed that triptolide suppresses the growth of ICC by inhibiting glycolysis via the AKT/mTOR pathway, offering a potential therapeutic target for ICC treatment.
Article
Oncology
Haowei Wang, Yujia Chen, Qinzi Yuan, Lixia Chen, Peiling Dai, Xuenong Li
Summary: This study found that HRK is lowly expressed in colorectal cancer tissues. For the first time, it was shown that HRK promotes apoptosis and inhibits proliferation of colorectal cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. HRK represents a potential target for the treatment of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Pengfei Zhang, Yuan Shao, Fang Quan, Lifeng Liu, Jin Yang
Summary: FBP1 promotes radiosensitivity in NPC cells by inhibiting glycolysis through the FBXW7/mTOR axis.
Article
Oncology
Rahil Ghanbarnasab Behbahani, Amir Danyaei, Ali Teimoori, Mohammad Javad Tahmasbi, Niloofar Neisi
Summary: This study investigated the synergistic effects of OPN gene knockout and radiotherapy in MDA-MB-231 breast cancer cells using CRISPR/Cas9 technique. The results showed that the combination of OPN gene knockout and radiotherapy promoted cell apoptosis, suppressed downstream gene expression, reduced cell viability, and inhibited cell cycle progression. Additionally, this approach substantially altered DNA damage responses.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Tianyu Li, Tiantao Kuang, Zhaoshuo Yang, Qiqi Zhang, Wen Zhang, Yue Fan
Summary: This study identified the mechanism of resistance of pancreatic cancer cells to genistein, with DEPTOR expression levels being associated with drug resistance and mTOR signaling activation playing a role in genistein-resistant PC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiuyan Chen, Haiying Zhang, Yimeng Yang, Shuming Zhang, Jing Wang, Dawei Zhang, Huimei Yu
Summary: In this study, the potential skin protective mechanism of Metformin (MF) in UVA-induced chronic skin damage was investigated using cell and mouse models. The results suggest that MF exerts anti-photoaging effects by inhibiting mitophagy and the PI3K/AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon, Sang-Kyu Ye
Summary: Under conditions of tumor acidosis, the expression of PD-L1 significantly increases and it is likely mediated by activation of the STAT3 signaling pathway. This finding provides new insights into the study of tumor immune evasion mechanisms.