期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2019, 期 20, 页码 3105-3111出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900209
关键词
Homogeneous catalysis; Organocatalysis; Tandem catalysis; -Aminophosphonates; Chiral phosphoric acids
The selective N-alkylation of anilines with benzylic alcohols can be switched in favor of the dehydrogenative condensation process using the nitrile-ligated Knolker's complex by conducting the reaction either in a closed system under inert conditions, or in an open system in air. The selective formation of imines, containing reactive C=N bonds, provides an opportunity towards further functionalization. Indeed, a one-pot three-component condensation of alcohols, amines and phosphites, promoted by an iron-based Knolker-type complex in combination with a chiral BINOL-based phosphoric acid, provides access to enantioenriched -N-alkylaminophosphonates.
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