期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 164, 期 -, 页码 678-688出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2018.12.017
关键词
Isatin; Hybrid compounds; Anti-Bacterial; Structure-activity relationship
资金
- Natural Science Fund of Liaoning Province [2015020680]
Bacterial infections are account for the majority of hospital-acquired and community-acquired infections. The emergency and widespread of drug-resistant pathogens has further worsened the situation. In recent years, various isatin derivatives have been screened for their anti-bacterial activities, and some of them demonstrated promising in vitro and in vivo potency. This review covers the recent advances of isatin derivatives including isatin-azole, isatin-quinoline/quinolone, isatin-furan/coumarin, isatin-hydrazone/(thio)semicarbazone, isatin dimers and isatin-indole hybrids as potential anti-bacterial agents. The enriched structure-activity relationship may pave the way for further rational development of isatin derivatives with broader spectrum, higher potency, lower toxicity and multiple mechanisms of action. (C) 2018 Elsevier Masson SAS. All rights reserved.
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