期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 164, 期 -, 页码 366-377出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2018.12.057
关键词
Salinomycin; Polyether ionophores; Cancer stem cells; Targeted therapy; Multi-drug resistance; Sensitizing effects; Synergy; Mechanism of action; Toxicity
资金
- Polish Science Centre (NCN) [2016/23/D/ST5/00242]
- Foundation for Polish Science (FNP)
Tumors are phenotypically heterogeneous and include a small sub-population of cancer cells (2-5% of the tumor mass) with stem-cell like properties. The cancer stem cell hypothesis postulates that the cancer stem cells (CSCs) show the ability to seed the tumor to distant tissues/organs, and their presence results in cancer progression and relapses. Extensive efforts have therefore been directed at new therapy strategies to eliminate not only non-CSCs, but also cancer cells with stem-cell like properties. Importantly, in 2009, the natural ionophore - salinomycin (SAL) was shown to be promising in this respect; SAL selectively and efficiently reduced the proportion of breast CSCs in vitro and in vivo. Since this original report, SAL has been shown to be active against numerous cancer cells and CSCs of different origin, including those that display multi-drug resistance. This concise review article is focused on the possible role of SAL in future cancer therapy. (C) 2018 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据