Article
Health Care Sciences & Services
Pauline Ducrot, Ilaria Montagni, Viet Nguyen Thanh, Anne-Juliette Serry, Jean-Baptiste Richard
Summary: The study revealed the changes in the evolution of internet as a source of health information and the characteristics, sources, and trustworthiness of online health information seekers from 2010 to 2017. The use of the internet for health information seeking continuously increased during this period but showed a decrease in 2017, along with a decline in trust in the quality and reliability of online information.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Anna Freytag, Eva Baumann, Matthias Angermeyer, Georg Schomerus
Summary: In a face-to-face survey in Germany, factors related to mental health information-seeking were investigated. The study found that individuals' proximity to mental health issues, education level, and desire for social distance from affected people play an important role in information-seeking. Differences in sociodemographic and proximity factors were observed between self-seekers and surrogate-seekers.
Article
Psychology, Multidisciplinary
Qian Li, Xue Yang, Xin Wang, Han Zhang, Ningning Ding, Wenqian Zhao, Wenwen Tian, Jiankang He, Mingxuan Du, Haiyan Hu, Guohua Zhang
Summary: This study aimed to evaluate the relationship between COVID-19 symptoms and health anxiety in individuals infected with COVID-19, as well as the mediation paths between them. The results showed that COVID-19 symptoms influenced health anxiety through internet health information-seeking behavior and perceived stigma. Therefore, interventions for reducing health anxiety should focus on improving the quality of online health information, enhancing individuals' online health literacy, and reducing stigma during and after pandemics.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Communication
Joseph Schwartz, Josh Grimm, Rick Zimmerman, Meredith Clement
Summary: This study found that men who have sex with men most frequently obtained information about HIV from HIV organizations, LGBT organizations, and dating/hookup apps, with Scruff app being the strongest predictor of beliefs about PrEP and condoms. Implications for health promotion were discussed.
HEALTH COMMUNICATION
(2022)
Article
Oncology
Seyedeh Leila Mousavi, Mandana Saki, Fatemeh Mohammadipour, Mohammad Gholami, Mohammad Almasian, Fatemeh Jafari Pour
Summary: This qualitative study explored the experiences of cancer patients seeking health information and identified three central categories. The findings highlight the importance of understanding how patients obtain health information in order to promote their health literacy and design a tailored health information dissemination system.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Nursing
Duygu Gulec Satir
Summary: This study examined the online information-seeking behaviors and antenatal anxiety of expectant fathers. The results showed that majority of expectant fathers searched for information online during pregnancy, with the most frequent topics being fetal development, complications to pregnancy, and nutrition. The study also found that expectant fathers who searched for information on vaccination during pregnancy, exercise, antenatal tests, labor pain, and childbirth signs had higher anxiety scores.
Review
Health Care Sciences & Services
Hanna Choi, Gyeonghui Jeong
Summary: This paper reviews 13 survey tools from 8 countries worldwide to explore the characteristics of measurement tools for assessing health information-seeking behaviors in nationally representative surveys. The survey tools mainly focus on domains such as information, channel, and health, encompassing behavioral and attitude dimensions.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Peivand Bastani, Mohammad Amin Bahrami, Kostas Kapellas, Alireza Yusefi, Giampiero Rossi-Fedele
Summary: This study explores the experience of seeking online oral health information and investigates the associations between online oral health information seeking behavior and oral health knowledge, attitudes, and practices (KAP) of participants. The results indicate that online oral health information seeking behavior is related to oral health KAP, emphasizing the need for planning, education, and empowerment of individuals' health literacy.
Article
Public, Environmental & Occupational Health
Emily Pfender, Amy Bleakley
Summary: This study, guided by the reasoned action approach, examined young adults' attitudes towards seeking health information from social media influencers through focus groups. Results suggest that young adults perceive influencers as a source of health education, but also face barriers such as sponsorship, lack of credibility, and normative pressure from peers and family.
QUALITATIVE HEALTH RESEARCH
(2023)
Review
Psychology, Multidisciplinary
Megan Conrad
Summary: This review synthesizes cross-disciplinary literature on women's health information-seeking behavior on the internet during pregnancy and childbirth, and provides suggestions for future research in each area. The findings can help healthcare providers better understand patients' informational needs and guide patients on how to evaluate information.
JOURNAL OF REPRODUCTIVE AND INFANT PSYCHOLOGY
(2022)
Article
Psychology, Applied
Michael Horvath, Nicole A. Celin, Ryan Murcko, Brittany P. Bate, Christopher A. Davis
Summary: This study aims to understand job-seekers' beliefs about job-seeking strategies and establish a typology and measurement tool for these beliefs. The findings show that job-seekers have different beliefs about different strategies, and some beliefs have unique relationships with job-seeker effort and motivation.
JOURNAL OF MANAGERIAL PSYCHOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Maddalena Fiordelli, Sara Rubinelli, Nicola Diviani
Summary: This study aimed to enhance the understanding of factors associated with public acceptance of public health measures during the COVID-19 pandemic. A cross-sectional survey of the Swiss population was conducted, revealing that individuals with higher education levels were more likely to use channels from public institutions, newspapers, and television for information. Trust in doctors, healthcare workers, universities, research institutes, and public health institutions was high. Overall acceptance of public health measures was high, and attitudes, beliefs, information-seeking behavior, and trust were positively related to acceptance. Trust in science remained stable, while trust in public health institutions slightly decreased.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Xiaoyun Jia, Yan Pang, Liangni Sally Liu
Summary: This paper systematically reviews online health information seeking behavior, identifies general behavioral patterns, influencing factors, facilitators, and barriers to this behavior.
Article
Health Care Sciences & Services
Ryusuke Suzuki, Teppei Suzuki, Shintaro Tsuji, Kensuke Fujiwara, Hiroko Yamashina, Akira Endoh, Katsuhiko Ogasawara
Summary: This study aims to propose a hospital website search behavior model by analyzing browsing behavior through a Bayesian network perspective of one-to-one marketing. By analyzing the website access log of Hokkaido University Hospital, access records related to radiology were specified, and 3 Bayesian network models were structured based on specific patient needs. The results showed that almost all target visitors could reach their requested page, but only a few were able to reach other specific pages.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Health Care Sciences & Services
Hooi Min Lim, Adam G. Dunn, Jing Ran Lim, Adina Abdullah, Chirk Jenn Ng
Summary: The evidence of the association between online health information-seeking (OHIS) and medication adherence is inconclusive. This review highlights methodological issues related to measuring OHIS objectively and calls for further research on how OHIS affects health decisions and behavior.
Article
Medicine, Research & Experimental
Katharine Cheng, Fenna Mahler, Irja Lutsar, Begonya Nafria Escalera, Stefanie Breitenstein, Gilles Vassal, Joana Claverol, Nuria Noel Palacio, Ron Portman, Gavin Pope, Martijn Bakker, Tessa van Der Geest, Mark A. A. Turner, Saskia N. N. de Wildt
Summary: Many medicines are used off-label in children outside the terms of the license. The Conect4children project aims to establish a pan-European pediatric clinical trial network to facilitate the development of new medicines for children. The project has successfully set up a multidisciplinary advice service, including the input of young patients and families, to optimize pediatric trial development and provide valuable advice to trial sponsors.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Evelina Cardoso, Anaelle Monfort, Ema Ferreira, Hedvig Nordeng, Ursula Winterfeld, Karel Allegaert, Peggy Gandia, Monia Guidi, Alice Panchaud
Summary: Human milk is the best nutrition for infants, and taking medication postpartum is common. Discontinuing breastfeeding is often wrongly advised due to concerns of adverse effects on the infant, even though only a few drugs are strictly prohibited while breastfeeding. Most drugs are transferred from the mother's blood to the milk, but the amount ingested by the infant is usually small. As there is limited population-based evidence on drug safety during breastfeeding, risk assessment relies on available clinical evidence, pharmacokinetic principles, and specialized sources of information for clinical decision-making. Risk assessment should consider both the potential risk to the infant and the benefits and risks associated with breastfeeding and maternal disease. Identifying situations with potential for drug accumulation in the infant is crucial for risk assessment. Healthcare providers should assume maternal concerns and utilize risk communication to ensure medication adherence without interrupting breastfeeding unnecessarily. Decision support algorithms and strategies can be used to minimize drug exposure in the breastfed infant, even when clinically not justified.
Article
Nutrition & Dietetics
Michael Ceulemans, Joline van de Vel, Dorine W. W. Swinkels, Coby M. M. Laarakkers, Jaak Billen, Kristel Van Calsteren, Karel Allegaert
Summary: This observational study aimed to provide the first data on cord blood hepcidin levels in a Belgian cohort and determine variables associated with cord blood hepcidin concentrations. The study found a moderate correlation between cord blood hepcidin and cord blood ferritin and hemoglobin, as well as an association with mode of delivery.
Article
Peripheral Vascular Disease
Yu-Ling Yu, Paula Moliterno, De-Wei An, Anke Raaijmakers, Dries S. Martens, Katarzyna Stolarz-Skrzypek, Valerie Tikhonoff, Sofia Malyutina, Edoardo Casiglia, Babangida Chori, Jan Filipovsky, Marek Rajzer, Karel Allegaert, Kalina Kawecka-Jaszcz, Peter Verhamme, Tim S. Nawrot, Jan A. Staessen, Jose Boggia
Summary: This study did not confirm its previous hypothesis, but demonstrated a correlation between birth weight and adult weight, and suggested that low birth weight increases salt sensitivity.
JOURNAL OF HYPERTENSION
(2023)
Article
Pediatrics
Pieter Schellekens, Marcelien Verjans, Peter Janssens, Angelique Dachy, Stephanie De Rechter, Luc Breysem, Karel Allegaert, Bert Bammens, Rudi Vennekens, Pieter Vermeersch, Hans Pottel, Djalila Mekahli
Summary: This study examined a cohort of 68 genotyped ADPKD patients and compared several commonly used equations for estimating eGFR. The CKiD and CKiDU25 equations showed age or sex differences, while the FAS equations were independent of age and sex. Therefore, having reliable methods to calculate eGFR is crucial for clinical follow-up and trials.
PEDIATRIC NEPHROLOGY
(2023)
Article
Psychiatry
Anaelle Monfort, Evelina Cardoso, Chin B. Eap, Celine J. Fischer Fumeaux, Myriam Bickle Graz, Mathilde Morisod Harari, Etienne Weisskopf, Peggy Gandia, Karel Allegaert, Hedvig Nordeng, Jean-Michel Hascoet, Olivier Claris, Manuella Epiney, Chantal Csajka, Monia Guidi, Ema Ferreira, Alice Panchaud
Summary: Two women diagnosed with depression were treated with 50 mg fluvoxamine during pregnancy and lactation. The results showed minimal exposure to fluvoxamine during lactation, which is consistent with previous studies. Larger clinical and pharmacokinetic studies are needed to assess the long-term safety of this drug during lactation and the variability of its exposure through breastmilk.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Pediatrics
Marina-Stefania Stroe, Lieselotte Van Bockstal, Allan Valenzuela, Miriam Ayuso, Karen Leys, Pieter Annaert, Sebastien Carpentier, Anne Smits, Karel Allegaert, Adrian Zeltner, Antonius Mulder, Chris Van Ginneken, Steven Van Cruchten
Summary: Animal models provide valuable information on human disease mechanisms and (patho)physiological factors affecting drug development. Nonclinical data is critical for understanding pediatric disease conditions and developing new drug therapies. This study aimed to develop a neonatal Gottingen Minipig model for investigating the impact of systemic hypoxia and therapeutic hypothermia on drug disposition in perinatal asphyxia.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Nina Nauwelaerts, Julia Macente, Neel Deferm, Rodolfo Hernandes Bonan, Miao-Chan Huang, Martje Van Neste, David Bibi, Justine Badee, Frederico S. S. Martins, Anne Smits, Karel Allegaert, Thomas Bouillon, Pieter Annaert
Summary: Currently, there is limited information about the safety of maternal medicines for breastfed infants. This study developed a generic physiologically-based pharmacokinetic (PBPK) model to predict concentrations of ten different medicines in human milk. The PBPK models accurately predicted plasma concentrations for non-lactating individuals and reasonably predicted milk concentrations for lactating individuals. This generic PBPK model is an important tool for assessing the safety of maternal medication during lactation.
Meeting Abstract
Neurosciences
Michael Ceulemans, Morgane Meylemans, Laurien Raskin, Laure Sillis, Veerle Foulon, Titia Hompes, Lore Lannoo, Anne Smits, Kristel Van Calsteren, Karel Allegaert, Loes de Vries, Saskia Vorstenbosch, Benedikte Cuppers, Anneke Passier
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Meeting Abstract
Neurosciences
Laure Sillisa, Cleo Vandegoor, Cato Vercaeren, Karel Allegaert, Annick Bogaerts, Maarten De Vos, Titia Hompes, Anne Smits, Kristel Van Calsteren, Jan Y. Verbakel, Veerle Foulon, Michael Ceulemans
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wojciech Krzyzanski, Pia Wintermark, Pieter Annaert, Floris Groenendaal, Suzan Sahin, Mehmet Yekta Oncel, Didem Armangil, Esin Koc, Malcolm R. Battin, Alistair J. Gunn, Adam Frymoyer, Valerie Y. -L. Chock, Elif Keles, Djalila Mekahli, John van den Anker, Anne Smits, Karel Allegaert
Summary: This study aims to use a population model to investigate the time course and variability of serum creatinine (sCr) in (near) term neonates with moderate to severe encephalopathy during and after therapeutic hypothermia (TH). The study found that acute kidney injury (AKI) has a strong impact on sCr kinetics and glomerular filtration rate (GFR). Birth weight and gestational age were not significant factors. Therapeutic hypothermia transiently increased sCr levels in neonates, while neonates with AKI exhibited delayed postnatal GFR increase and higher sCr synthesis rate.
Article
Medicine, General & Internal
E. Degraeuwe, L. Persijn, L. Nuytinck, K. Allegaert, L. De Taeye, E. Gasthuys, D. Christiaens, S. Karamaria, A. Raes, M. Turner, J. Vande Walle
Summary: Pediatric clinical trials are often hindered by limited evidence-based dosing, lack of expertise, and regulatory burdens. The Belgian Paediatric Clinical Research Network has been relaunched in 2018 to address these issues and improve trial quality, safety, and efficiency. Collaboration, government support, and site-level improvements are crucial for lasting transformation in pediatric medicine research.
ACTA CLINICA BELGICA
(2023)
Review
Pharmacology & Pharmacy
Martje Van Neste, Annick Bogaerts, Nina Nauwelaerts, Julia Macente, Anne Smits, Pieter Annaert, Karel Allegaert
Summary: Physiologically based pharmacokinetic (PBPK) modelling is a method to predict pharmacokinetics in specific populations based on population-specific and medicine-specific data. This review focuses on the challenges of developing PBPK models for postpartum, lactating women and breastfed infants, including factors such as postpartum weight retention, human milk intake, and changes in milk composition and enzymatic activities. The currently available models lack structured systematic acquisition of population-specific data, and future directions include systematic searches to fully identify physiological data and improve the models.
Review
Obstetrics & Gynecology
Themistoklis Dagklis, Ranjit Akolekar, Cecilia Villalain, Ioannis Tsakiridis, Assaad Kesrouani, Aydin Tekay, Walter Plasencia, Sven Wellmann, Satoshi Kusuda, Nelly Jekova, Federico Prefumo, Nicola Volpe, Petya Chaveeva, Karel Allegaert, Asma Khalil, Cihat Sen
Summary: This practice guideline aims to improve the management of preterm labor and provides further guidance for healthcare practitioners on diagnosing preterm labor and the appropriate use of medications.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Peripheral Vascular Disease
Yu-Ling Yu, De-Wei An, Wen-Yi Yang, Peter Verhamme, Karel Allegaert, Tim S. Nawrot, Jan A. Staessen
Summary: The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure and renal function responses in workers without previous occupational lead exposure over a period of 6 years. The results showed that there was no significant correlation between the changes in blood pressure and renal function and the increase in blood lead level. Therefore, it can be concluded that modern lead-handling facilities operating under current safety rules are safe.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
