期刊
ENVIRONMENT INTERNATIONAL
卷 123, 期 -, 页码 171-180出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2018.11.055
关键词
Urine metals; Oxidative stress; Metal mixtures; Population-based
资金
- Strategic Action for Research in Health Sciences [CP12/03080, PI10/0082, PI13/01848, PI07/0497, PI11/00726]
- Valencia Government [GRUPOS 03/101, PROMETEO/2009/029, 2005/027, AMP07/075, ACOMP/2013/039]
- Castilla-Leon Government [GRS/279/A/08]
- European Network of Excellence Ingenious Hypercare from the European Commission [EPSS-037093]
- Retics [PREDIMED RD06/0045/0006]
- CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn) [CIBER-02-08-2009, CB06/03, CB12/03/30016]
- CIBER de Diabetes y Enfermedades Metabolicas Relacionadas [CIBERDEM CB07/0/018]
- European Funds for Regional Development (FEDER)
Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8-oxo-7,8-dihydroguanine(8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA. Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
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