Article
Oncology
Yi Fang, He Wang, Ming Feng, Hongjie Chen, Wentai Zhang, Liangfeng Wei, Zhijie Pei, Renzhi Wang, Shousen Wang
Summary: In this study, a CNN model was used to assess cavernous sinus invasion (CSI) in pituitary adenoma (PA), and it showed a high proficiency in diagnosis compared to the traditional Knosp grading system.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Yi Fang, Zhijie Pei, Hongjie Chen, Renzhi Wang, Ming Feng, Liangfeng Wei, Jun Li, Heng Zhang, Shousen Wang
Summary: The study found that grades 2-4, 3-4, and 3B-4 of the Knosp grade had good discriminative abilities in predicting CSI, and modifying the KG improved its prognostic role in CSI and gross total resection. However, the reliability of the scale's middle grades (grades 2 and 3A) was weak, and therefore these grading systems cannot be used as a standard for invasive and non-invasive pituitary adenomas. It is recommended that future studies report KG as high, medium, and low to optimize the application of the scale.
Article
Clinical Neurology
Lijun Heng, Hang Wang, Shuo Zhang, Xue Jiang, Yan Qu
Summary: The cavernous sinus molding technique with hemostatic agent injection during endoscopic endonasal pituitary surgery is a practical, effective, and safe method for controlling intracavernous bleeding. It involves making a small incision in the cavernous sinus wall, injecting the hemostatic agent along the venous channels to establish partial molding, and using tailored instruments for injection. Multi-spot injections are preferred for better bleeding control and reducing complications. Postoperative complications were not observed in the patients treated with this technique.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Abdelsimar T. Omar, David G. Munoz, Jeannette Goguen, John M. Lee, Fabio Rotondo, Kalman Kovacs, Michael D. Cusimano
Summary: Resection of the medial wall of the cavernous sinus using BETS appears to be safe and technically feasible for treating patients with functioning pituitary adenomas. There were no significant differences observed in biochemical remission and tumor control rates during the follow-up period in the cohort.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyeryeong Park, Yeo Kyung Nam, Ho Sung Kim, Ji Eun Park, Da Hyun Lee, Joonsung Lee, Seonok Kim, Young-Hoon Kim
Summary: A comparative study on 104 patients found that 1-mm deep learning reconstruction (DLR) provides better delineation of the pituitary axis and identification of cavernous sinus invasion for pituitary macroadenoma compared to routine 3-mm MRI imaging.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Yuanzhi Xu, Ahmed Mohyeldin, Karam P. Asmaro, Maximiliano Alberto Nunez, Ayoze Doniz-Gonzalez, Vera Vigo, Aaron A. Cohen-Gadol, Juan C. Fernandez-Miranda
Summary: Superior, lateral, and posterior compartments of the cavernous sinus have unique anatomical features as potential breakthrough routes for invasive pituitary adenomas. Understanding these patterns is crucial for achieving higher resection rates and remission rates.
OPERATIVE NEUROSURGERY
(2022)
Article
Surgery
Ethan Harel, Giulia Cossu, Roy Thomas Daniel, Mahmoud Messerer
Summary: This study analyzed the surgical outcomes of L- and G-PAs based on factors such as tumor relationship with the diaphragm, invasion of CS, and invasion of the subarachnoid space. Results showed that most patients had grade 1 tumors and achieving GTR was linked to lower CS invasion rates. Radiological evaluation plays a crucial role in planning surgical strategy for L- and G-PAs.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Liang Lu, Xueyan Wan, Yu Xu, Juan Chen, Kai Shu, Ting Lei
Summary: This study aimed to identify clinical factors associated with tumor recurrence and develop a nomogram to predict postoperative recurrence in patients with pituitary adenomas (PAs) who underwent gross-total resection (GTR). The study found that pseudocapsule-based extracapsular resection, cavernous sinus invasion, and tumor size were independent predictors of PA recurrence. The developed nomogram showed good predictive accuracy and could facilitate individualized counseling for patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Atsushi Ishida, Hideki Shiramizu, Haruko Yoshimoto, Masataka Kato, Naoko Inoshita, Nobuhiro Miki, Masami Ono, Shozo Yamada
Summary: This study evaluated the effects of medial wall of cavernous sinus (MWCS) resection during functioning pituitary tumor (FPT) surgery. The results showed that MWCS invasion occurred in 57% of cases histologically confirmed, and its resection improved the overall complete remission rate in FPT cases.
Article
Oncology
FuMing Yang, YunKe Bi, QiangYi Zhou, HongChan Li, YaJun Xue, QingWei Zhu, Jian Yin, ZhiYu Wang, MeiQing Lou
Summary: The study aimed to understand the characteristics and growth corridors of Knosp grade 4 pituitary adenomas (Knosp4PA) with cavernous sinus (CS) compartments penetration and intracranial extension. A case series of 120 Knosp4PA patients was reviewed, and a novel surgery-relevant grading system was proposed. The study found that the grading system can improve the total resection rate of Knosp4PA.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Zhijie Pei, Jiaxing Wang, Shuwen Mu, Tianshun Feng, Meina Wang, Shentong Yu, Liangfeng Wei, Yi Fang, Shousen Wang
Summary: The study found that factors such as Knosp grade 3-4, a greater proportion of suprasellar tumor volume, and evidence of invasion of the cavernous sinus during surgery make it more difficult to completely remove giant pituitary adenomas.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Sida Zhao, Bin Li, Yiyuan Chen, Chuzhong Li, Yazhuo Zhang
Summary: The study investigates the expression and prognostic value of HSPB1 in pituitary adenomas with invasive and non-invasive features, as well as its potential relationship with immune functions. Analysis of 159 pituitary adenoma specimens reveals that HSPB1 is upregulated in invasive tumors and affects immune cell infiltration. High expression of HSPB1 is significantly associated with poorer overall survival and it plays a role in immune system regulation. Inhibitors of HSPB1 expression could potentially be used as therapy for invasive pituitary adenoma.
MEDICINA-LITHUANIA
(2023)
Article
Clinical Neurology
Nicholas Chang, Jessica W. Grayson, Joao Mangussi-Gomes, Sebastian Fung, Raquel Alvarado, Mark Winder, Benjamin P. Jonker, Ann McCormack, Richard J. Harvey
Summary: This study aimed to assess the diagnostic performance of four MRI criteria in diagnosing cavernous sinus invasion by pituitary tumors. The Knosp criteria, percentage encasement of the internal carotid (PEICA), and venous compartment obliteration (VCO) were found to be the most effective indicators of CSI, while the presence of certain signs indicated a lower likelihood of CSI. Alternatives to the Knosp criteria, such as PEICA and VCO, can aid in the diagnosis of CSI.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Simona Serioli, Pedro Plou, Luciano C. P. C. Leonel, Stephen Graepel, Barbara Buffoli, Rita Rezzani, Marco Maria Fontanella, Pietro Luigi Poliani, Francesco Doglietto, Michael J. Link, Carlos D. Pinheiro-Neto, Maria Peris-Celda
Summary: This study proposes the candy wrapper model to describe the anatomy of the medial wall of the cavernous sinus (MWCS) and parasellar ligaments (PLs). The study identifies two groups of fan-shaped ligaments that connect to the anterior and posterior walls of the cavernous sinus, providing important information for safe cavernous sinus surgery, including resection of functioning pituitary adenomas (FPAs).
ACTA NEUROCHIRURGICA
(2023)
Article
Oncology
Taohui Ouyang, Na Zhang, Shenhao Xie, Bin Tang, Junjun Li, Limin Xiao, Fabao Zhang, Bowen Wu, Dongwei Zhou, Meihua Li, Tao Hong
Summary: The study retrospectively analyzed outcomes and complications in 102 patients with Knosp grade 4 pituitary adenomas. It found that patients with complete resection of the entire tumor were more likely to have favorable endocrine and visual outcomes, and that recurrent tumors and firm consistency tumors were adverse factors for complete resection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Ryota Tamura, Hiroyuki Miyoshi, Kazunari Yoshida, Hideyuki Okano, Masahiro Toda
Summary: Malignant glioma, a highly aggressive primary brain tumor, has poor prognosis and requires new therapeutic modalities. Suicide gene therapy has gained attention, with recent focus on using tumor-tropic stem cells as cellular delivery vehicles. This approach shows potential for effective treatment of malignant gliomas.
NEUROSURGICAL REVIEW
(2021)
Article
Medicine, General & Internal
Yuki Kuranari, Ryota Tamura, Noboru Tsuda, Kenzo Kosugi, Yukina Morimoto, Kazunari Yoshida, Masahiro Toda
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Ryota Tamura, Yukina Morimoto, Kenzo Kosugi, Mizuto Sato, Yumiko Oishi, Ryo Ueda, Ryogo Kikuchi, Hideaki Nagashima, Shinobu Noji, Yutaka Kawakami, Hikaru Sasaki, Kazunari Yoshida, Masahiro Toda
Article
Oncology
Ryota Tamura, Toshihide Tanaka, Yukina Morimoto, Yuki Kuranari, Yohei Yamamoto, Jun Takei, Yuichi Murayama, Kazunari Yoshida, Hikaru Sasaki
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Pathology
Ryota Tamura, Mizuto Sato, Yukina Morimoto, Kentaro Ohara, Kenzo Kosugi, Yumiko Oishi, Yuki Kuranari, Makoto Murase, Kazunari Yoshida, Masahiro Toda
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2020)
Article
Pathology
Makoto Murase, Ryota Tamura, Yuki Kuranari, Mizuto Sato, Kentaro Ohara, Yukina Morimoto, Kazunari Yoshida, Masahiro Toda
Summary: The depth and patterns of dural invasion in meningiomas were quantitatively evaluated, and it was found that the invasion patterns were associated with meningioma recurrence.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Immunology
Ryota Tamura, Yukina Morimoto, Mizuto Sato, Tetsuro Hikichi, Kazunari Yoshida, Masahiro Toda
Article
Clinical Neurology
Mizuto Sato, Ryota Tamura, Yukina Morimoto, Yumiko Oishi, Kazunari Yoshida, Masahiro Toda
Summary: This study found an association between activated fibroblasts and dura matere-like membrane capsules in LVMs. The characteristics of membranous structure in LVMs may differ depending on tumor size.
WORLD NEUROSURGERY
(2021)
Review
Biochemistry & Molecular Biology
Ryota Tamura
Summary: Neurofibromatosis is a neurocutaneous syndrome characterized by tumors in the nervous system, with NF1, NF2, and SWN as its three main types. While NF1 and NF2 have known genetic mutations and targeted therapies, the molecular mechanisms of SWN remain unclear and require further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yumiko Oishi, Ryota Tamura, Kazunari Yoshida, Masahiro Toda
Summary: The dura-like membrane (DLM) is an membranous structure arising from the dura mater adjacent to the internal auditory meatus that envelops some vestibular schwannomas (VSs). Recognition of DLM is important for preserving facial and cochlear nerves during tumor resection. The study found that the presence of DLM was associated with lower tumor resection volume, larger intratumoral vessel diameter, and higher intratumoral microvessel density.
Review
Biochemistry & Molecular Biology
Ryota Tamura, Masahiro Toda
Summary: Vestibular schwannoma is a benign tumor that originates from Schwann cells. Gamma knife radiosurgery is an accepted treatment, while targeted therapy and immunotherapy show potential for refractory cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Kento Takahara, Makoto Katayama, Ryota Tamura
Summary: Leptomeningeal carcinomatosis (LMC) is a rare but devastating complication of advanced cancer, more commonly caused by breast cancer, lung cancer, and melanoma. Treatment with intrathecal chemotherapy via Ommaya reservoir and radiation therapy has shown success in prolonging survival in patients with LMC from ovarian cancer.
Article
Biotechnology & Applied Microbiology
Ryota Tamura, Hiroyuki Miyoshi, Kent Imaizumi, Masahiro Yo, Yoshitaka Kase, Tsukika Sato, Mizuto Sato, Yukina Morimoto, Oltea Sampetrean, Jun Kohyama, Munehisa Shinozaki, Atsushi Miyawaki, Kazunari Yoshida, Hideyuki Saya, Hideyuki Okano, Masahiro Toda
Summary: This study demonstrates the potential benefit of gene-edited induced pluripotent stem cells (iPSCs) for the treatment of invasive glioma stem cells (GSCs). Neural stem cells (NSCs) derived from CRISPR/Cas9-edited iPSCs expressing a suicide gene showed enhanced tumor-trophic migratory capacity and significant in vivo antitumor effects. The study also identified key signaling pathways and gene expressions associated with the efficacy of therapeutic iPSC-NSCs.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ryota Tamura
Summary: Drug repositioning is the process of identifying new therapeutic potentials for approved drugs and discovering new therapies for untreated diseases. It can save time and cost compared to de novo drug discovery. This article reviews the utility of drug repositioning for refractory benign tumors of the central nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ryosuke Tomio, Takashi Horiguchi, Hamid Borghei-Razavi, Ryota Tamura, Kazunari Yoshida, Takeshi Kawase
Summary: The anterior transpetrosal approach (ATPA) has been used for surgery since 1985, and this study analyzed 274 cases performed from 1984 to 2017. Petroclival meningioma was the most common diagnosis. Modifications to the ATPA, such as zygomatic osteotomy, were used to decrease complications, but brain injury and CSF leak remained unresolved problems. Facial nerve damage decreased after 2010, but CSF leak incidence did not improve.
JOURNAL OF NEUROSURGERY
(2022)