Article
Oncology
Chanjuan Peng, Yong Wu, Yang Yang, Ningning Li, Xi Chen, Linhui Gu, Dong Xu, Chen Yang
Summary: The study demonstrated the enhanced destructive effect of UTMD combined with 4 Gy radiotherapy on glioblastoma, likely achieved through increased ability of DNA damage of tumor cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chao Zhang, Shuyuan Chen, Qunying Li, Jiao Wu, Fuqiang Qiu, Zhiyi Chen, Yang Sun, Jieli Luo, Raul A. Bastarrachea, Paul A. Grayburn, Ralph A. DeFronzo, Yajing Liu, Kun Qian, Pintong Huang
Summary: The study demonstrated successful gene delivery of GLP-1 in macaques using UTMD, leading to enhanced GLP-1 expression and improvement in pancreatic beta cell regeneration and plasma glucose regulation. This approach shows promising alternatives for treating type 2 diabetes.
Review
Oncology
Senbo Liu, Yan Zhang, Yang Liu, Wenkang Wang, Shuochen Gao, Weitang Yuan, Zhenqiang Sun, Lin Liu, Chengzeng Wang
Summary: Cancer immunotherapy has made promising progress, but its therapeutic efficacy needs to be improved. Ultrasound-targeted microbubble destruction is an emerging technology that can remodel the tumor microenvironment and enhance the effectiveness of immunotherapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Hui Li, Yao Zhang, Hong Shu, Wenhao Lv, Chunhong Su, Fang Nie
Summary: This article reviews recent developments in the application of UTMD-mediated gene and drug delivery in the diagnosis and treatment of tumors, including the concept, mechanism of action, clinical application status, and advantages of UTMD. Furthermore, future perspectives in this field are also discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Jinhui Gao, Keiran A. Logan, Heather Nesbitt, Bridgeen Callan, Thomas McKaig, Mark Taylor, Mark Love, Anthony P. McHale, Darren M. Griffith, John F. Callan
Summary: FIRINOX MB, an ultrasound responsive microbubble formulation containing 5-fluorouridine, irinotecan, and oxaliplatin, enhances the delivery of FIRINOX chemotherapy, resulting in significantly improved tumor growth delay and survival prospects in preclinical murine models of pancreatic and colorectal cancer. This improved efficacy is achieved at substantially lower drug loadings compared to standard FOLFIRINOX treatment, suggesting potential for reduced systemic levels and adverse effects.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Instruments & Instrumentation
Carlos A. Franco-Urquijo, J. Angel Navarro-Becerra, Amelia Rios, Bruno Escalante
Summary: The study evaluated a hybrid delivery system consisting of liposomes loaded with vascular agonists conjugated to microbubbles for targeted release using UMMD.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Lei Dong, Nana Li, Xixi Wei, Yongling Wang, Liansheng Chang, Hongwei Wu, Liujiang Song, Kang Guo, Yuqiao Chang, Yaling Yin, Min Pan, Yuanyuan Shen, Feng Wang
Summary: A new drug-loaded microbubble complex based on PLGA was developed to target GA to brain tumors through UTMD. The combination of GA/PLGA-CMB with FUS demonstrated a significant inhibitory effect on glioblastoma cell lines and effectively opened the BBB for targeted treatment of glioblastoma in a mouse model.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Lauren J. Delaney, John R. Eisenbrey, David Brown, Jonathan R. Brody, Masaya Jimbo, Brian E. Oeffinger, Maria Stanczak, Flemming Forsberg, Ji-Bin Liu, Margaret A. Wheatley
Summary: Ultrasound imaging has many advantages, and the development of microbubble contrast agents presents new opportunities for drug delivery. Gemcitabine-loaded microbubbles show potential therapeutic effects for pancreatic cancer.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Ai -Ho Liao, Yu -Chen Chen, Chia-Yu Chen, Shun-Cheng Chang, Ho-Chiao Chuang, Dao-Lung Lin, Chien-Ping Chiang, Chih-Hung Wang, Jehng-Kang Wang
Summary: The study found that ultrasound-mediated microbubble cavitation (US-MB) can enhance transdermal drug delivery by disrupting epidermal cell-cell junctions and increasing matriptase activity. US-MB was shown to be able to monitor active matriptase and its complex formation with HAI-1. This finding has important implications for the use of US-MB as a noninvasive method for transdermal drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Ines Beekers, Simone A. G. Langeveld, Bram Meijlink, Antonius F. W. van der Steen, Nico de Jong, Martin D. Verweij, Klazina Kooiman
Summary: This study investigated the interaction between microbubbles and endothelial cells during drug delivery. It found that targeted microbubbles were internalized by the cells, leading to changes in microbubble oscillation and resulting membrane perforation. The study provides important insights into the mechanisms of microbubble-mediated drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Kuo-Wei Chen, Po-Hung Hsu, Hau-Lun Huang, Hao-Li Liu, Ya-Tin Lin, Che-Yu Hsu, Jui-Hsiang Lin, Yu-Hsin Lin
Summary: This study utilizes targeted nanoparticle-conjugated microbubbles to ensure effective penetration of tumor barriers, access to the tumor microenvironment, and local drug release, utilizing ultrasound to release the nanoparticles. It is demonstrated that targeted nanoparticles can enter gastric cancer cells through ligand-specific recognition, leading to enhanced cell growth inhibition through drug delivery-induced apoptosis. Additionally, the ultrasound combined with nanoparticle-based drug delivery system significantly enhances anti-tumor activity in targeted gastric cancer.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Dennison Trinh, Joanne Nash, David Goertz, Kullervo Hynynen, Sharsi Bulner, Umar Iqbal, James Keenan
Summary: The study demonstrates the effective delivery of viral vector gene therapies to brain regions affected in Parkinson's disease (PD) using MR-guided focused ultrasound (MR-g-FUS) and microbubble drug conjugates (MDCs). This technology shows potential as a disease-modifying strategy in PD and other neurodegenerative disorders.
Article
Chemistry, Multidisciplinary
Harriet Lea-Banks, Ying Meng, Sheng-Kai Wu, Rania Belhadjhamida, Clement Hamani, Kullervo Hynynen
Summary: The study demonstrates that using ultrasound-sensitive nanodroplets in combination with Focused Ultrasound (FUS) can achieve neuromodulation in the rat nervous system without disrupting the blood-brain barrier. Results show that this method can induce neurosuppression or neurostimulation through local delivery of small molecule anesthetics or targeted mechanical effects.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Charis Rousou, Nicky van Kronenburg, Andreas F. P. Sonnen, Marijke van Dijk, Chrit Moonen, Gert Storm, Enrico Mastrobattista, Roel Deckers
Summary: Drug delivery to the retina faces challenges due to biological barriers. Ultrasound combined with microbubbles (USMB) can improve drug delivery to the retina. This study investigated the applicability of USMB for delivering model drugs in ex vivo porcine eyes. Results showed that USMB induced intracellular accumulation of drugs without causing irreversible alterations in retinal and choroid tissues.
Article
Pharmacology & Pharmacy
Yongho Jang, Jeehun Park, Pilsu Kim, Eun-Joo Park, Hyungjin Sun, Yujin Baek, Jaehun Jung, Tai-kyong Song, Junsang Doh, Hyuncheol Kim
Summary: In this study, exosome-fused microbubbles (Exo-MBs) were developed by embedding the exosome membrane proteins into microbubbles. The Exo-MBs showed improved stability over conventional microbubbles, and the resulting Exo-NPs demonstrated favorable targeting properties to their original cells. Loading a photosensitizer into Exo-MBs enhanced the therapeutic efficacy of photodynamic therapy, followed by cancer immunotherapy.
ACTA PHARMACEUTICA SINICA B
(2023)