Article
Biology
Rachel Warren, Handeng Lyu, Kylie Klinkhammer, Stijn P. De Langhe
Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by fibrotic alveolar remodeling and progressive loss of pulmonary function. Chronic alveolar injury and failure to repair the respiratory epithelium are intrinsic to IPF pathogenesis. Loss or dysfunction of alveolar type 2 (AT2) stem cells can trigger pulmonary fibrosis. Increased YAP activity in respiratory epithelial cells in IPF lungs may promote pulmonary fibrosis. However, recent research also shows that YAP and Taz are important for AT1 cell maintenance and alveolar epithelial regeneration. Targeting YAP may help promote AT1 cell regeneration and treat pulmonary fibrosis.
Article
Pharmacology & Pharmacy
Yuru Chen, Yanyan Wang, Yu Zhai, Ye Yuan, Junhong Wang, Yajing Jin, Lingling Dang, Liming Song, Changbao Chen, Yu Wang
Summary: Cinobufacini injection (CI), an aqueous extract of Cutis Bufonis, is clinically used for cancer therapy in China. In this study, we found that CI inhibited proliferation, induced cell cycle arrest and apoptosis in human osteosarcoma (OS) cells through down-regulating the PIN1-YAP/TAZ pathway. Further RNA-seq results identified the involvement of the Hippo signaling pathway. In addition, compounds in CI were able to inhibit PIN1 activity.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angel Ortega, Ivana Vera, Maria P. Diaz, Carla Navarro, Milagros Rojas, Wheeler Torres, Heliana Parra, Juan Salazar, Juan B. De Sanctis, Valmore Bermudez
Summary: Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are essential for cell growth regulation, embryonic development, regeneration, proliferation, and cancer. Their activation leads to the release of the transcriptional enhanced associate domain (TEAD) from its repressors, resulting in various biological effects. Overexpression of YAP/TAZ is associated with cancer stem cells and tumor resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Wentao Shi, Zhe Wang, Lu Bian, Yiqing Wu, Mei HuiYa, Yanjun Zhou, Zhijian Zhang, Qing Wang, Peng Zhao, Xiaojie Lu
Summary: This study found that periodic heat stress promotes the differentiation of EMSCs into osteoblasts, and YAP plays a key role in regulating the TG2 response.
STEM CELLS INTERNATIONAL
(2022)
Review
Cell Biology
Konstantin Masliantsev, Lucie Karayan-Tapon, Pierre-Olivier Guichet
Summary: The Hippo signaling pathway regulates organ size through cell proliferation and apoptosis, and has been shown to play a role in tumorigenesis and metastasis. Further investigation is needed to understand the role of this pathway in brain tumors and other malignant neoplasms.
Article
Cell Biology
Nan Wang, Yetong Dong, Xiejun Xu, Yingjie Shen, Zhiyuan Huang, Yin Yu, Zhili Liu, Wenjie Gong, Siyi Zhang, Yeyi Zheng, Yonghuan Song, Zhongxin Zhu, Litai Jin, Weitao Cong
Summary: The study found that FGF10 promotes keratinocyte proliferation and plays a protective role against UVB-induced skin damage. Additionally, FGF10 alleviates the downregulation of YAP activity induced by UVB, promoting keratinocyte proliferation.
CELL PROLIFERATION
(2022)
Review
Cell Biology
Feihong Deng, Zengrong Wu, Fei Zou, Su Wang, Xuehong Wang
Summary: This article provides an overview of the Hippo-YAP/TAZ signaling pathway and the processes of intestinal self-renewal and regeneration. The roles of YAP/TAZ in different phases are summarized, suggesting a potential strategy for treating inflammatory bowel disease (IBD).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Vincent Laiman, Ta-Chih Hsiao, Yu-Ting Fang, You-Yin Chen, Yu-Chun Lo, Kang-Yun Lee, Tzu-Tao Chen, Kuan-Yuan Chen, Shu-Chuan Ho, Sheng-Ming Wu, Jen-Kun Chen, Didik Setyo Heriyanto, Kian Fan Chung, Kin-Fai Ho, Kai-Jen Chuang, Jer-Hwa Chang, Hsiao-Chi Chuang
Summary: In this study, we investigated the relationship between Hippo signaling pathway components and the development of emphysema in air pollution-exposed ageing rats. The results showed that air pollution led to inflammation in the lungs and increased airway thickness, and the Hippo signaling pathway was dysregulated. The study also revealed the potential risk of emphysema development in smokers and COPD patients.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Zhifa Cao, Liwei An, Yi Han, Shi Jiao, Zhaocai Zhou
Summary: Gastric cancer is a highly aggressive disease without effective early diagnosis markers and targeted therapies, leading to high mortality rates worldwide. The Hippo signaling pathway, which is involved in organ size control and tissue homeostasis, has been found to play a crucial role in cancer development. This review provides a comprehensive overview of studies on the Hippo pathway in gastric cancer, including its role in tumor initiation, progression, metastasis, acquired drug resistance, and potential therapeutic strategies. The review aims to inspire further research and understanding of the Hippo signaling pathway in gastric cancer, as well as its translational implications for treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Lingquan Wang, Wei Xu, Yu Mei, Xufeng Wang, Wentao Liu, Zhenggang Zhu, Zhentian Ni
Summary: This study found that CHRDL2 is abnormally upregulated in gastric cancer and is associated with tumor progression and poor patient prognosis. CHRDL2 overexpression promotes proliferation and cell cycle transition of gastric cancer cells, and it plays a key role by activating the YAP/TAZ pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Yirao Zhang, Yang Wang, Hao Ji, Jie Ding, Keming Wang
Summary: The Hippo signaling pathway coordinately regulates cell regeneration and organ size, and dysregulation can lead to uncontrolled cell proliferation and cancer transformation. Noncoding RNAs play critical roles in cancer development and have complex interactions with YAP/TAZ signaling.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell & Tissue Engineering
Yi Xiao, Qin Liu, Nanyin Peng, Yuzhang Li, Danyang Qiu, Tianlun Yang, Richard Kang, Ahsan Usmani, Efosa Amadasu, Cesario Borlongan, Guolong Yu
Summary: Statins, commonly used drugs for controlling lipid levels, have shown the potential to lower colorectal cancer incidence and improve patient survival through inhibiting Wnt/β-catenin and YAP/TAZ signaling pathways. This study provides evidence supporting the clinical use of statins in non-cardiovascular contexts and identifies novel targets for anticancer treatments.
CELL TRANSPLANTATION
(2022)
Review
Biochemistry & Molecular Biology
Bianca Dietrich, Sandra Haider, Gudrun Meinhardt, Juergen Pollheimer, Martin Knoefler
Summary: This article discusses two important signaling pathways, WNT and NOTCH, in the development of human placenta and trophoblasts. The WNT pathway is necessary for the expansion of trophoblast progenitors and stem cells, while NOTCH1 is required for the proliferation and survival of extravillous trophoblast precursors.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rongsheng Huang, Atsushi Fujimura, Eiji Nakata, Shota Takihira, Hirofumi Inoue, Soichiro Yoshikawa, Takeshi Hiyama, Toshifumi Ozaki, Atsunori Kamiya
Summary: The study demonstrates that adrenaline increases cancer stem cell population in MPNST by activating the beta-2 adrenergic receptor and the Hippo transducer, YAP/TAZ. Inhibition of ADRB2 attenuates this effect and subsequently reduces MPNST cell stemness, indicating a potential new treatment strategy for MPNST.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Qian Zhang, Andrew J. Haak, Benita Sjogren
Summary: This study validates the inhibitory effect of regulator of G protein signaling 2 (RGS2) on uveal melanoma (UM) cell growth and suggests that this effect is dependent on the association between RGS2 and G alpha(q).
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)