Mechanisms of Notch signaling: a simple logic deployed in time and space

Dynamic Ligand Discrimination in the Notch Signaling Pathway

(2018) Nagarajan Nandagopal et al.   CELL

Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics

(2018) Maria J. Gomez-Lamarca et al.   DEVELOPMENTAL CELL

Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells

(2018) Jun Chen et al.   NATURE CELL BIOLOGY

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

(2018) Sandra Loerakker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programming self-organizing multicellular structures with synthetic cell-cell signaling

(2018) Satoshi Toda et al.   SCIENCE

Notching a New Pathway in Vascular Flow Sensing

(2018) Anne K. Lagendijk et al.   TRENDS IN CELL BIOLOGY

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

(2018) Lena Tveriakhina et al.   eLife

Novel TCR-Mediated Mechanisms of Notch Activation and Signaling

(2017) Martin Peter Steinbuck et al.   JOURNAL OF IMMUNOLOGY

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

Inhibition of Delta-induced Notch signaling using fucose analogs

(2017) Michael Schneider et al.   Nature Chemical Biology

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin

(2017) Amy E. Shyer et al.   SCIENCE

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Self-organized Notch dynamics generate stereotyped sensory organ patterns inDrosophila

(2017) Francis Corson et al.   SCIENCE

Genome-wide identification and characterization of Notch transcription complex–binding sequence-paired sites in leukemia cells

(2017) Eric Severson et al.   Science Signaling

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

(2017) Jennifer S. Fang et al.   Nature Communications

Genome-wide identification and characterization of Notch transcription complex–binding sequence-paired sites in leukemia cells

(2017) Eric Severson et al.   Science Signaling

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time

(2016) Daeha Seo et al.   CELL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

(2016) Kole T. Roybal et al.   CELL

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes

(2016) Franz Oswald et al.   NUCLEIC ACIDS RESEARCH

C. elegans GLP-1/Notch activates transcription in a probability gradient across the germline stem cell pool

(2016) ChangHwan Lee et al.   eLife

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors

(2015) M. Mori et al.   DEVELOPMENT

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation

(2015) L. Skalska et al.   EMBO JOURNAL

SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers

(2015) Matthew R. Hass et al.   MOLECULAR CELL

Parent stem cells can serve as niches for their daughter cells

(2015) Ana Pardo-Saganta et al.   NATURE

Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

(2015) Z. Guo et al.   SCIENCE

Long-distance communication by specialized cellular projections during pigment pattern development and evolution

(2015) Dae Seok Eom et al.   eLife

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates

(2014) J. Hatakeyama et al.   DEVELOPMENT

Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear

(2014) J. Petrovic et al.   DEVELOPMENT

Cis-interactions between Notch and its ligands block ligand-independent Notch activity

(2014) William Hunt Palmer et al.   eLife

Membrane Tethered Delta Activates Notch and Reveals a Role for Spatio-Mechanical Regulation of the Signaling Pathway

(2013) Yoshie Narui et al.   BIOPHYSICAL JOURNAL

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme

(2013) A. Terriente-Felix et al.   DEVELOPMENT

Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase

(2013) Alok Upadhyay et al.   JOURNAL OF CELL BIOLOGY

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub

(2012) A. Trofka et al.   DEVELOPMENT

Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins, and Actin

(2012) Laurence Meloty-Kapella et al.   DEVELOPMENTAL CELL

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome

(2012) M. Schneider et al.   JOURNAL OF CELL SCIENCE

Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit

(2012) Christian Schröter et al.   PLOS BIOLOGY

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

(2011) Jason R. Rock et al.   Cell Stem Cell

Mechanism and Significance of cis-Inhibition in Notch Signalling

(2011) David del Álamo et al.   CURRENT BIOLOGY

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

Evidence for Increased Exposure of the Notch1 Metalloprotease Cleavage Site upon Conversion to an Activated Conformation

(2011) Kittichoat Tiyanont et al.   STRUCTURE

Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning

(2011) David Sprinzak et al.   PLoS Computational Biology

Transcriptional control of stem cell maintenance in the Drosophila intestine

(2010) A. J. Bardin et al.   DEVELOPMENT

Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition

(2010) Michael Cohen et al.   DEVELOPMENTAL CELL

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

(2010) David Sprinzak et al.   NATURE

Error Minimization in Lateral Inhibition Circuits

(2010) O. Barad et al.   Science Signaling

γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane

(2010) Erika B. Sorensen et al.   TRAFFIC

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

cis-Inhibition of Notch by Endogenous Delta Biases the Outcome of Lateral Inhibition

(2009) Adam C. Miller et al.   CURRENT BIOLOGY

Endosomal entry regulates Notch receptor activation inDrosophila melanogaster

(2008) Thomas Vaccari et al.   JOURNAL OF CELL BIOLOGY

The molecular logic of Notch signaling - a structural and biochemical perspective

(2008) W. R. Gordon et al.   JOURNAL OF CELL SCIENCE