Article
Biochemistry & Molecular Biology
Lei Xu, Yanpin Li, Zixi Wei, Rong Bai, Ge Gao, Wenjuan Sun, Xianren Jiang, Junjun Wang, Xilong Li, Yu Pi
Summary: This study found that CDCA can promote the proliferation of IPEC-J2 cells by regulating cell cycle progression and mitochondrial function.
Article
Biochemistry & Molecular Biology
Jinting Liu, Yihong Wei, Wenbo Jia, Can Can, Ruiqing Wang, Xinyu Yang, Chaoyang Gu, Fabao Liu, Chunyan Ji, Daoxin Ma
Summary: Our study revealed that CDCA suppresses AML progression by synergistically promoting LDs accumulation and lipid peroxidation via the ROS/p38 MAPK/DGAT1 pathway caused by mitochondrial dysfunction in leukemia cells, as well as inhibiting M2 macrophage polarization.
Review
Microbiology
Peng Song, Xue Zhang, Wei Feng, Wei Xu, Chaoyun Wu, Shaoqing Xie, Sisi Yu, Rongzhao Fu
Summary: Ursodeoxycholic acid (UDCA) is a fundamental treatment drug for hepatobiliary diseases and shows potential therapeutic effects on certain cancers and neurological diseases. The chemical synthesis of UDCA is environmentally unfriendly, and the development of biological synthesis methods using free-enzyme catalysis or whole-cell synthesis is underway.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Clinical Neurology
Kun Nie, Yanyi Li, Jiahui Zhang, Yuyuan Gao, Yihui Qiu, Rong Gan, Yuhu Zhang, Lijuan Wang
Summary: This study found that there are different bile acid profiles between patients with PD-MCI and PD-NC. Lower levels of CDCA, CA, and UDCA were significantly associated with PD-MCI and may be distinct bile acid signatures for patients with PD-MCI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Materials Science, Multidisciplinary
Xue Jiang, Mingshu Cui, Wei Zhang, Luyao Xie, Lu Xu
Summary: Novel twisted rod-like structured chiral mesoporous silicas (CMSs) were successfully synthesized using template systems from UDCA/CDCA and CTAB, showing high optical activity and chiral-selective drug delivery properties. These CMSs are expected to be desirable carriers for drug delivery in the pharmaceutical field, expanding the applications of inorganic nanomaterials.
Article
Biochemistry & Molecular Biology
Elisabetta Melloni, Elena Marchesi, Lorenzo Preti, Fabio Casciano, Erika Rimondi, Arianna Romani, Paola Secchiero, Maria Luisa Navacchia, Daniela Perrone
Summary: Chenodeoxycholic acid and ursodeoxycholic acid were conjugated with paclitaxel to improve its ability to enter cancer cells, while exhibiting lower toxicity on healthy cells.
Article
Multidisciplinary Sciences
On You Kim, Seung Yun Lee, Da Young Lee, Sun Jin Hur
Summary: This study developed simple methods for extracting chenodeoxycholic acid (CDCA) and synthesizing ursodeoxycholic acid (UDCA) from pig by-products. The enzymatic method using bile salt hydrolase (BSH) enzymes was found to be more efficient than the chemical method. The chemical method yielded UDCA amounts of 6.05 mg, 0.51 mg, 3.04 mg, and 1.26 mg per 100 g of the liver, stomach, small intestine, and large intestine, respectively. The amounts of UDCA synthesized per 100 g through the chemical and enzymatic methods for extracting CDCA were 3.48 g and 2.22 g, respectively. The procedure developed in this study was simplified by three stages compared to the conventional chemical method of extracting CDCA, and it also provided a technique for improving the utilization of pig by-products.
Article
Cell Biology
Eun-Hye Jang, Jung-Ho Lee, Soon-Ae Kim
Summary: In this study, we found that treatment with valproic acid induced mitochondrial biogenesis and autophagy in the SH-SY5Y cell line by altering FOXO3a expression and posttranslational modification.
Article
Cell Biology
Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Edan Johnston, Maja Danic, Momir Mikov, Crispin Dass, Hani Al-Salami
Summary: The study investigated the applications of chenodeoxycholic acid (CDCA) in bio-encapsulation and transplantation of primary healthy viable islets. Results showed that islet encapsulation by CDCA microcapsules performed better in terms of glycemic control and modulation of the bile acid profile in the brain, indicating short-term improvement in graft insulin delivery and glycemic control.
Article
Cell Biology
Jessica Elswood, Scott J. Pearson, H. Ross Payne, Rola Barhoumi, Monique Rijnkels, Weston W. Porter
Summary: Through studying the differentiation and metabolism of mammary epithelial cells, it was found that mitophagy occurs selectively during the differentiation process. Inhibiting autophagy impairs cell differentiation, while the PRKN protein is necessary for cell differentiation.
Review
Physiology
Lorand Kiss, Gabriella Fur, Sailaja Pisipati, Prasad Rajalingamgari, Nils Ewald, Vijay Singh, Zoltan Rakonczay
Summary: Hypertriglyceridemia (HTG) is a metabolic disorder characterized by high levels of triglycerides in the blood, and it increases the risk of acute pancreatitis (AP). This review discusses the pathophysiology of HTG-induced AP and the role of fatty acids in causing the consequences of HTG during AP. Experimental results suggest that reducing fatty acid production through lipase inhibitors may offer new therapeutic options for AP.
Article
Materials Science, Multidisciplinary
Lemin Mao, Shuopan Dun, Hehe Ren, Jiamin Jiang, Xugeng Guo, Fuhua Huang, Panpan Heng, Li Wang, Jinglai Zhang, Hans Agren
Summary: The study demonstrates that adding coadsorbents and introducing electron-withdrawing groups can effectively enhance the power conversion efficiency (PCE) of dye-sensitized solar cells (DSSCs). By designing rational molecular structures and utilizing coadsorption, higher PCE and photovoltaic efficiency can be achieved. This opens up a new avenue for designing efficient organic sensitizers for promising DSSC applications by exploring the impact of coadsorbents and electron-withdrawing groups on the optoelectronic properties of dyes.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Gastroenterology & Hepatology
Nuria Lluis, Horacio Asbun, Sandra Basso, Natalia Corzo-Zamora, Andres Gelrud, Edson Guzman-Calderon, Edgard E. Lozada-Hernandez, Carla Mancilla, Rodrigo Mansilla-Vivar, Analia V. Pasqua, Mario Pelaez-Luna, Guido Villa-Gomez Roig, Pedro Zapater, Felix Lluis, Eva Vaquero, Jose Manuel Ramia, Enrique de Madaria
Summary: Little is known about the initial management of acute pancreatitis in Latin America, and surveyed physicians in this region show lower adherence to clinical guidelines compared to the rest of the world, particularly in the areas of feeding and nutrition.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Medicine, Research & Experimental
Pham Xuan Thuy, Tran Duc Duy Bao, Eun-Yi Moon
Summary: The study found that ursodeoxycholic acid (UDCA) can inhibit abnormal airway epithelial cell migration and contribute to the repair of damaged epithelial basal layer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Endocrinology & Metabolism
David P. Sonne
Summary: The gastrointestinal tract plays a crucial role in regulating glucose homeostasis, with bile acids being recognized as metabolic regulators impacting lipid, glucose, and energy metabolism. The farnesoid X receptor (FXR) is an important component of the bile acid-sensing system that affects bile acid pool size and metabolic processes such as glucose and lipid metabolism. Natural and synthetic FXR agonists, as well as FXR-regulated factors like fibroblast growth factor 19 (FGF19), are being evaluated as potential treatments for metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emese Reka Balint, Gabriella Fur, Balazs Kui, Zsolt Balla, Eszter Sara Kormanyos, Erik Mark Orjan, Brigitta Toth, Gyoengyi Horvath, Edina Szucs, Sandor Benyhe, Eszter Ducza, Petra Pallagi, Jozsef Maleth, Viktoria Venglovecz, Peter Hegyi, Lorand Kiss, Zoltan Rakonczay Jr
Summary: This study aimed to investigate the effects of clinically relevant opioids on the severity of acute pancreatitis. The researchers found that the type, dosage, administration route, and timing of opioid treatment can influence their effects on the severity of pancreatitis. Specifically, post-treatment with fentanyl was beneficial for necrotizing pancreatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Gastroenterology & Hepatology
B. Jojart, T. Molnar, V Szabo, A. Varga, T. Resal, K. Szanto, D. Kata, I Foldesi, T. Molnar, J. Maleth, K. Farkas
JOURNAL OF CROHNS & COLITIS
(2022)
Editorial Material
Neurosciences
Jozsef Maleth
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Petra Pallagi, Marietta Gorog, Noemi Papp, Tamara Madacsy, Arpad Varga, Tim Crul, Viktoria Szabo, Melinda Molnar, Krisztina Dudas, Anna Grassalkovich, Edit Szederkenyi, Gyorgy Lazar, Viktoria Venglovecz, Peter Hegyi, Jozsef Maleth
Summary: Regardless of its aetiology, sustained intracellular Ca2+ overload is a well-known hallmark of acute pancreatitis. This study demonstrates that functionally active Orai1 channels reside predominantly in the apical plasma membrane of pancreatic ductal cells. Selective Orai1 inhibition impairs Ca2+ influx and protects ductal cell secretory function, suggesting Orai1 inhibition as a potential treatment for improving the outcome of acute pancreatitis.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Materials Science, Biomaterials
Szilard Saringer, Tamas Valtner, Arpad Varga, Jozsef Maleth, Istvan Szilagyi
Summary: A hybrid material with dual enzyme function was prepared by optimizing the doses of enzymes and polyelectrolyte in each step to achieve high functional and colloidal stability. The enzymes and polyelectrolyte were strongly adsorbed on microsphere surfaces via electrostatic forces, preventing enzyme leakage. The polyelectrolyte acted as a separator between enzymes to maintain the colloidal stability and functionality of the hybrid material.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Neurosciences
Fruzsina R. Walter, Andras Harazin, Andrea E. Toth, Szilvia Veszelka, Ana R. Santa-Maria, Lilla Barna, Andras Kincses, Gyorgy Biczo, Zsolt Balla, Balazs Kui, Jozsef Maleth, Laszlo Cervenak, Vilmos Tubak, Agnes Kittel, Zoltan Rakonczay, Maria A. Deli
Summary: The study demonstrated BBB damage in the l-ornithine-induced rat AP model, suggesting a general effect independent of the AP model. l-ornithine induced oxidative stress, decreased barrier integrity, and altered BBB morphology in a culture BBB model. The cationic l-ornithine was found to have a direct effect on brain endothelium, causing injury to endothelial surface glycocalyx in both in vivo and in vitro settings.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Biochemistry & Molecular Biology
Tamara Madacsy, Arpad Varga, Noemi Papp, Balint Tel, Petra Pallagi, Viktoria Szabo, Aletta Kiss, Julia Fanczal, Zoltan Rakonczay Jr, Laszlo Tiszlavicz, Zsolt Razga, Meike Hohwieler, Alexander Kleger, Mike Gray, Peter Hegyi, Jozsef Maleth
Summary: Alcoholic pancreatitis and hepatitis are common and potentially lethal diseases. This study found that ethanol impairs the expression of CFTR Cl- channel, leading to disrupted intracellular Ca2+ homeostasis in pancreatic and liver cells. The study also suggests that improving cellular Ca2+ extrusion may be a novel therapeutic approach for protecting pancreatic function and preventing cholestasis in alcoholic liver disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mate Nagy-Penzes, Zoltan Hajnady, Zsolt Regdon, Mate A. Demeny, Katalin Kovacs, Tarek El-Hamoly, Jozsef Maleth, Peter Hegyi, Csaba Hegedus, Laszlo Virag
Summary: Acute pancreatitis is a worldwide challenge due to its increasing incidence and life-threatening course. The flavone compound, tricetin, shows potential protective effects in acute pancreatitis by reducing inflammation, necrosis, and oxidative DNA damage.
Review
Physiology
Lorand Kiss, Gabriella Fur, Sailaja Pisipati, Prasad Rajalingamgari, Nils Ewald, Vijay Singh, Zoltan Rakonczay
Summary: Hypertriglyceridemia (HTG) is a metabolic disorder characterized by high levels of triglycerides in the blood, and it increases the risk of acute pancreatitis (AP). This review discusses the pathophysiology of HTG-induced AP and the role of fatty acids in causing the consequences of HTG during AP. Experimental results suggest that reducing fatty acid production through lipase inhibitors may offer new therapeutic options for AP.
Article
Biochemistry & Molecular Biology
Balint Tel, Noemi Papp, Arpad Varga, Viktoria Szabo, Marietta Gorog, Petra Susanszki, Tim Crul, Aletta Kis, Ingrid H. Sendstad, Maria Bagyanszki, Nikolett Bodi, Peter Hegyi, Jozsef Maleth, Petra Pallagi
Summary: This study found that exposure to azathioprine had negative effects on the function of pancreatic ductal cells, leading to reduced secretion of pancreatic fluid, bicarbonate, and chloride ions. In addition, azathioprine inhibited RAC1 activity in ductal cells, resulting in decreased co-localization of CFTR and ezrin and impaired plasma membrane localization of CFTR.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Medicine, General & Internal
Norbert Kovacs, Daniel Pecsi, Zoltan Sipos, Nelli Farkas, Maria Foldi, Peter Hegyi, Judit Bajor, Balint Eross, Katalin Marta, Alexandra Miko, Jr Zoltan Rakonczay, Patricia Sarlos, Szabolcs Abraham, Aron Vincze
Summary: A meta-analysis compared the efficacy of suprapapillary stent placement and transpapillary stent placement. The results showed that suprapapillary stent placement has longer patency and lower cholangitis rate in cases of malignant indications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. Rutka, K. Szanto, P. Bacsur, T. Resal, B. Jojart, A. Balint, E. Ari, B. Kintses, T. Feher, A. Asboth, D. Pigniczki, R. Bor, A. Fabian, K. Farkas, J. Maleth, Z. Szepes, T. Molnar
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
A. Balint, P. Bacsur, T. Resal, B. Jojart, Z. Gyuris, G. Jaksa, L. Pinter, B. Takacs, S. Pal, A. Gacser, K. J. Szanto, M. Rutka, R. Bor, A. Fabian, K. Farkas, J. Maleth, Z. Szepes, T. Molnar
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
B. Jojart, T. Molnar, D. Kata, V. Szabo, A. Varga, T. Resal, P. Bacsur, K. Szanto, I. Foldesi, T. Molnar, J. Maleth, K. Farkas
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
T. Molnar, B. Jojart, T. Resal, K. Szanto, D. Kata, I. Foldesi, T. Molnar, J. Maleth, K. Farkas
JOURNAL OF CROHNS & COLITIS
(2022)