Article
Medicine, Research & Experimental
Shiqi Zhong, Raphael Chevre, David Castano Mayan, Maria Corliano, Blake J. Cochran, Kai Ping Sem, Theo H. van Dijk, Jianhe Peng, Liang Juin Tan, Siddesh V. Hartimath, Boominathan Ramasamy, Peter Cheng, Albert K. Groen, Folkert Kuipers, Julian L. Goggi, Chester Drum, Rob M. van Dam, Ru San Tan, Kerry-Anne Rye, Michael R. Hayden, Ching-Yu Cheng, Shaji Chacko, Jason Flannick, Xueling Sim, Hong Chang Tan, Roshni R. Singaraja
Summary: Reduced CYP8B1 activity is associated with increased insulin sensitivity in humans, possibly due to increased skeletal muscle insulin sensitivity caused by increased circulating CDCA.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Juan Xu, Yongchang Zhou, Siyang Cheng, Yuling Zhao, Junkai Yan, Ying Wang, Wei Cai, Lu Jiang
Summary: L. johnsonii protects against liver steatosis, bile acid dysregulation, and hepatocyte apoptosis in total parenteral nutrition (TPN)-fed rats. It inhibits fatty acid synthesis, promotes fatty acid oxidation, restores bile acid synthesis and secretion, and reduces pathogenic bacteria in the gut. L. johnsonii also directly inhibits hepatocyte apoptosis induced by glycochenodeoxycholic acid (GCDCA) through bile salt hydrolase (BSH) activity.
Article
Chemistry, Organic
Uxia Gomez-Bouzo, Alioune Fall, Judit Osz, Yagamare Fall, Natacha Rochel, Hugo Santalla
Summary: This study describes the synthesis of six novel Gemini cholesterol analogues and investigates the binding mode of one of them with ROR gamma.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Baixue Li, Shi-Ying Cai, James L. Boyer
Summary: Retinoic acid receptors (RARs) and retinoid X receptors (RXRs), activated by retinoids, play crucial roles in various biological processes such as embryo development, homeostasis, cell proliferation, differentiation and death. In liver physiology, RAR/RXR heterodimers regulate lipid and bile acid synthesis and metabolism, cholesterol transport in macrophages, and fibrogenesis in hepatic stellate cells. Specific genes carrying out these functions are regulated by RAR/RXR in liver cells, providing a mechanistic understanding of their roles in liver physiology. Still, detailed signaling mechanisms of RAR/RXR in regulating liver gene expression remain to be fully elucidated in future studies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Pediatrics
Nan Wang, Jiazheng Wang, Tian Zhang, Liufang Huang, Weihui Yan, Lina Lu, Jie Jia, Yijing Tao, Wei Cai, Ying Wang
Summary: This study found changes in the taxonomic and functional composition of gut microbiota in a rat model of PNALD, leading to an increase in secondary bile acid production.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Gastroenterology & Hepatology
Gulisudumu Maitiabula, Feng Tian, Peng Wang, Li Zhang, Xuejin Gao, Songlin Wan, Haifeng Sun, Jianbo Yang, Yupeng Zhang, Tingting Gao, Bin Xue, Chaojun Li, Jieshou Li, Xinying Wang
Summary: PP2A-Cα plays an important role in the pathogenesis of PNAHS, acting as a protective factor by improving hepatic steatosis and liver function. A decrease in PP2A-Cα leads to activation of Akt2 and inhibition of AMPK, exacerbating hepatic steatosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zeyu Dong, Fangzhou He, Xiaosong Yan, Yuanming Xing, Yuyang Lei, Jie Gao, Ming He, Dongmin Li, Liang Bai, Zuyi Yuan, John Y-J Shyy
Summary: Elevated levels of Ch25h and its enzymatic product 25-HC alleviate HFD-induced hepatic steatosis by regulating enterohepatic circulation of bile acids, involving 25-HC activation of CYP7A1 via liver X receptor. Targeting Ch25h or 25-HC may have therapeutic advantages against nonalcoholic fatty liver disease.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Weipeng Wang, Ying Wang, Yang Liu, Xinbei Tian, Shanshan Chen, Ying Lu, Bo Wu, Yongtao Xiao, Wei Cai
Summary: This study found that Lactobacillus plantarum CGMCC 1258 can alleviate liver and intestinal injury in PN-fed neonatal piglets by altering the composition of intestinal bacteria and bile acids.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Lu Jiang, Ying Wang, Yongtao Xiao, Yong Wang, Junkai Yan, Bernd Schnabl, Wei Cai
Summary: PNALD is a spectrum of liver diseases that can develop when using parenteral nutrition, with an intricate linkage to gut microbiota as potential noninvasive biomarkers. Microbial metabolites and signaling pathways play a key role in the pathogenesis of PNALD.
JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
T. Hang Nghiem-Rao, Courtney Pfeifer, Michelle Asuncion, Joshua Nord, Daniel Schill, Kirthi Pulakanti, Shailendra B. Patel, Lisa A. Cirillo, Sridhar Rao
Summary: This study compared gene expression patterns in human fetal/infant livers, adult liver, and iHLC, finding significant downregulation in xenobiotic, bile acid, and fatty acid metabolism in developing livers and iHLC compared to adults, along with lower expression of the sterol metabolizing gene ABCG8. The study also showed higher lipid accumulation in iHLC compared to adult-derived HepG2 cells when challenged with stigmasterol, supporting the use of iHLC as a relevant model system for studying lipid metabolism and PNAC in developing liver.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Yun Chen, Shu-Ping Zhang, Wei-Wei Gong, Yang-Yang Zheng, Jie-Ru Shen, Xiao Liu, Yun-Hui Gu, Jia-Hai Shi, Guo-Liang Meng
Summary: This review summarizes the understanding and potential effects of retinoid-related orphan receptor alpha (ROR alpha) in the cardiovascular system, as well as current advances, limitations, challenges, and future strategies for ROR alpha-related drugs in cardiovascular diseases. ROR alpha influences various physiological and pathological processes in the cardiovascular system and is involved in the regulation of inflammation, apoptosis, autophagy, oxidative stress, ER stress, and mitochondrial function. Synthetic ROR alpha agonists or antagonists have been developed in addition to natural ligands. The review highlights the protective roles and possible mechanisms of ROR alpha against cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Cristy R. C. Verzijl, Ivo P. van de Peppel, Roos E. Eilers, Vincent W. Bloks, Justina C. Wolters, Martijn Koehorst, Niels J. Kloosterhuis, Rick Havinga, Mathilde Jalving, Dicky Struik, Johan W. Jonker
Summary: The RAS-MAPK signaling pathway is frequently dysregulated in human cancer. In this study, the researchers aimed to explore the early effects of pharmacological inhibition of this pathway on the liver. They found that the inhibition resulted in profound changes in bile acid metabolism, which may explain the clinical adverse effects of RAS-MAPK pathway inhibition.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Peijie Wu, Ling Qiao, Han Yu, Hui Ming, Chao Liu, Wenjun Wu, Baixue Li
Summary: The study demonstrates that arbutin has a protective effect on cholestatic liver injury induced by ANIT by upregulating FXR and downstream enzymes associated with bile acid homeostasis. Furthermore, the findings suggest that arbutin may be a potential chemical molecule for cholestatic diseases by partly acting through the FXR pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jing Zeng, Jiangao Fan, Huiping Zhou
Summary: Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), gradually progress to liver fibrosis, cirrhosis, and failure. Disruption of bile acid metabolism and intrahepatic circulation plays a crucial role in accelerating the progression of cholestatic liver diseases. Bile acids not only act as detergents for nutrition absorption but also function as key signaling molecules that regulate hepatic metabolism and immune responses. This review focuses on the role of bile acid-mediated signaling in cholestatic liver disease.
CELL AND BIOSCIENCE
(2023)
Article
Respiratory System
Hak-Su Kim, Chang Hyeok An, Danielle Teller, Su-Jin Moon, Gi Won Hwang, Jin Woo Song
Summary: This study found that ROR alpha promotes autophagy and contributes to the pathogenesis of COPD through the regulation of the ROR alpha-p53-DRAM pathway.
RESPIRATORY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Bo Kong, Yan Zhu, Guodong Li, Jessica A. Williams, Kyle Buckley, Ossama Tawfik, James P. Luyendyk, Grace L. Guo
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2016)
Article
Pharmacology & Pharmacy
Runbin Sun, Na Yang, Bo Kong, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Jingqiu Huang, Jianliang Shen, Pei Wang, Siqi Feng, Fei Fei, Jiahua Guo, Jun He, Nan Aa, Qiang Chen, Yang Pan, Justin D. Schumacher, Chung S. Yang, Grace L. Guo, Jiye Aa, Guangji Wang
MOLECULAR PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
J. D. Schumacher, B. Kong, Y. Pan, L. Zhan, R. Sun, J. Aa, D. Rizzolo, J. R. Richardson, A. Chen, M. Goedken, L. M. Aleksunes, D. L. Laskin, G. L. Guo
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2017)
Article
Gastroenterology & Hepatology
Bo Kong, Runbin Sun, Mingxing Huang, Monica D. Chow, Xiao-Bo Zhong, Wen Xie, Yi-Horng Lee, Grace L. Guo
Article
Gastroenterology & Hepatology
Xiaoying Liu, Grace L. Guo, Bo Kong, David B. Hilburn, Susan C. Hubchak, Seong Park, Brian LeCuyer, Antony Hsieh, Li Wang, Deyu Fang, Richard M. Green
Article
Multidisciplinary Sciences
Sangwon Byun, Dong-Hyun Kim, Daniel Ryerson, Young-Chae Kim, Hao Sun, Bo Kong, Peter Yau, Grace Guo, H. Eric Xu, Byron Kemper, Jongsook Kim Kemper
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Young-Chae Kim, Sunmi Seok, Sangwon Byun, Bo Kong, Yang Zhang, Grace Guo, Wen Xie, Jian Ma, Byron Kemper, Jongsook Kim Kemper
NATURE COMMUNICATIONS
(2018)
Editorial Material
Gastroenterology & Hepatology
Bo Kong, Grace L. Guo
Article
Gastroenterology & Hepatology
Bo Kong, Min Zhang, Mingxing Huang, Dan Rizzolo, Laura E. Armstrong, Justin D. Schumacher, Monica D. Chow, Yi-Horng Lee, Grace L. Guo
DIGESTIVE AND LIVER DISEASE
(2019)
Article
Gastroenterology & Hepatology
Justin D. Schumacher, Bo Kong, Jason Wu, Daniel Rizzolo, Laura E. Armstrong, Monica D. Chow, Michael Goedken, Yi-Horng Lee, Grace L. Guo
Article
Medicine, Research & Experimental
Mingxing Huang, Bo Kong, Min Zhang, Daniel Rizzolo, Laura E. Armstrong, Justin D. Schumacher, Monica D. Chow, Yi-Horng Lee, Laurie B. Joseph, Mary Stofan, Lanjing Zhang, Grace L. Guo
LABORATORY INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Young-Chae Kim, Sunmi Seok, Yang Zhang, Jian Ma, Bo Kong, Grace Guo, Byron Kemper, Jongsook Kim Kemper
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Sunmi Seok, Young-Chae Kim, Yang Zhang, Bo Kong, Grace Guo, Jian Ma, Byron Kemper, Jongsook Kim Kemper
Summary: This study found that autophagy/lipophagy is activated in the intestines after feeding, and this activation is dependent on the orphan nuclear receptor SHP and the gut hormone FGF15/19. In addition, deficiency of SHP and FGF15 leads to elevated levels of postprandial intestinal triglycerides and ApoB48. Genomic analysis showed that SHP partners with the lysosomal activator TFEB to upregulate the transcription of autophagy/lipolysis network genes after feeding. Treatment with FGF19 activated lipophagy and reduced TG and ApoB48 levels in intestinal cells, which depended on TFEB.
Article
Gastroenterology & Hepatology
Bo Kong, Mingxing Huang, Rulaiha E. Taylor, Daniel Rizzolo, Katherine D. Otersen, Grace L. Guo
Summary: The study suggests that intestine-specific Fgf15 deficiency may lead to increased liver injury in the development of ALD.