Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity

Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance

(2015) Pär Steneberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes

(2015) Arif U. Hasan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

The endocrinology of taste receptors

(2015) Sara Santa-Cruz Calvo et al.   Nature Reviews Endocrinology

The genetic architecture of NAFLD among inbred strains of mice

(2015) Simon T Hui et al.   eLife

Functional roles of the sweet taste receptor in oral and extraoral tissues

(2014) Anni Laffitte et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Sweet Taste Receptors Regulate Basal Insulin Secretion and Contribute to Compensatory Insulin Hypersecretion During the Development of Diabetes in Male Mice

(2014) George A. Kyriazis et al.   ENDOCRINOLOGY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass

(2014) Becky R. Simon et al.   PLoS One

Disordered Control of Intestinal Sweet Taste Receptor Expression and Glucose Absorption in Type 2 Diabetes

(2013) R. L. Young et al.   DIABETES

Artificial Sweeteners Stimulate Adipogenesis and Suppress Lipolysis Independently of Sweet Taste Receptors

(2013) Becky R. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells

(2013) Yosuke Masubuchi et al.   PLoS One

G-protein-coupled receptors as fat sensors

(2012) Marco A.R. Vinolo et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Non-Nutritive Sweeteners and their Role in the Gastrointestinal Tract

(2012) Rebecca J. Brown et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice

(2012) John I. Glendinning et al.   PHYSIOLOGY & BEHAVIOR

Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion

(2012) G. A. Kyriazis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hormonal Regulation of Hepatic Glucose Production in Health and Disease

(2011) Hua V. Lin et al.   Cell Metabolism

Hyperinsulinemia and the Development of Nonalcoholic Fatty Liver Disease in Nondiabetic Adults

(2010) Eun-Jung Rhee et al.   AMERICAN JOURNAL OF MEDICINE

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

(2010) Mikael Bjursell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Prevalence and Trends in Obesity Among US Adults, 1999-2008

(2010) Katherine M. Flegal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Relationship Between Obesity and Diabetes in a US Adult Population: Findings from the National Health and Nutrition Examination Survey, 1999–2006

(2010) Ninh T. Nguyen et al.   OBESITY SURGERY

Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones

(2009) Zaza Kokrashvili et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

T1R receptors mediate mammalian sweet and umami taste

(2009) Xiaodong Li   AMERICAN JOURNAL OF CLINICAL NUTRITION

T1r3 and α-Gustducin in Gut Regulate Secretion of Glucagon-like Peptide-1

(2009) Zaza Kokrashvili et al.   Annals of the New York Academy of Sciences

The gut microbiota modulates host energy and lipid metabolism in mice

(2009) Vidya R. Velagapudi et al.   JOURNAL OF LIPID RESEARCH

Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion

(2009) Yuko Nakagawa et al.   PLoS One

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding

(2008) M. Kebede et al.   DIABETES

Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes

(2008) Anna Kotronen et al.   GASTROENTEROLOGY

Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes

(2008) R L Young et al.   GUT