Article
Immunology
Peter Goettle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Kuery
Summary: This study demonstrates that teriflunomide modulates oligodendroglial precursor cell homeostasis and promotes myelin repair in the cuprizone mediated de-/remyelination model. Teriflunomide treatment accelerates the generation of oligodendrocytes and restoration of myelin sheaths, and restores mitochondrial integrity within oligodendroglial cells. These findings highlight the importance of de novo pyrimidine synthesis inhibition and mitochondrial homeostasis in successful myelin repair and axonal protection.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, Research & Experimental
Mariarosaria Cammarota, Valeria de Rosa, Anna Pannaccione, Agnese Secondo, Valentina Tedeschi, Ilaria Piccialli, Ferdinando Fiorino, Beatrice Severino, Lucio Annunziato, Francesca Boscia
Summary: The NCX3 inhibitor BED antagonized NCX activity, induced OPCs proliferation, and enhanced [Na+](i) accumulation. After 2 days of BED washout following 4 days of treatment, there was upregulation of low molecular weight NCX3 proteins, reversal of NCX activity, and an increase in intracellular [Ca2+](i) levels, promoting myelin marker expression in rat primary oligodendrocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Sana Kari, Akshaya Murugesan, Ramesh Thiyagarajan, Srivatsan Kidambi, Jamoliddin Razzokov, Chandrabose Selvaraj, Meenakshisundaram Kandhavelu, Parthiban Marimuthu
Summary: Glioblastoma Multiforme (GBM) is the most aggressive brain tumor in adults, with a median survival rate of less than 15 months. The GBM cells develop resistance to chemo-and radiotherapy, indicating the need for novel preventative measures. The study identified potential GPR17 modulators using virtual screening and molecular dynamics simulations, and validated their effectiveness in inhibiting GBM cell accumulation. This research provides new insights into the development of targeted therapies for deadly diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Clinical Neurology
Jessica R. Allanach, John W. Farrell, Miceline Mesidor, Soheila Karimi-Abdolrezaee
Summary: This study systematically reviewed recent advances in neuroprotective and regenerative therapies for MS, finding that small molecules and antibody therapies are the most common strategies for promoting remyelination. However, further research is needed to address current barriers in implementing experimental treatments in clinical settings.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Review
Chemistry, Medicinal
Abid Mahmood, Jamshed Iqbal
Summary: Purinergic signaling mediated by multiple receptor subtypes plays a crucial role in the treatment of neurodegenerative and cardiovascular diseases, and shows potential in other therapeutic areas.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Cell Biology
Horst Penkert, Alix Bertrand, Vini Tiwari, Stephan Breimann, Stephan A. Mueller, Paul M. Jordan, Mathias J. Gerl, Christian Klose, Ludovico Cantuti-Castelvetri, Mar Bosch-Queralt, Ilya Levental, Stefan F. Lichtenthaler, Oliver Werz, Mikael Simons
Summary: The study reveals that n-3 fatty acids can promote the balance of inflammatory reactions, reduce phagocytic infiltrate, accelerate the decline of microglia/macrophages, enhance oligodendrocyte generation, and ultimately improve lesion recovery in demyelinating injuries of the central nervous system.
Review
Cell Biology
Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Tousif Ahmed Hediyal, Praveen Raj, Annan Gopinath Rathipriya, M. Walid Qoronfleh, Musthafa Mohamed Essa, Saravana Babu Chidambaram
Summary: Dendritic spines play a crucial role in neurodegenerative diseases, and various treatments have been shown to improve their structure and distribution. Both pharmacological and non-pharmacological modulators significantly enhance dendritic spine structure and functions, ultimately reversing the pathologies associated with neurodegeneration.
Article
Biochemistry & Molecular Biology
Xinxiu Fang, Jiunn-Tyng Yeh, Tzyh-Chang Hwang
Summary: A study investigated the pharmacological responses of translational products of G542X-CFTR to new CFTR modulators. The study found that a read-through protein produced through a read-through process is functional and responds well to CFTR potentiators, while a C-terminus truncated protein does not. It also concluded that an efficacious read-through reagent is necessary for mitigating the deficits of G542X-CFTR. CFTR potentiators may improve the effectiveness of future combinational therapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Catarina Pimpao, Darren Wragg, Ines V. da Silva, Angela Casini, Graca Soveral
Summary: Aquaglyceroporins play important roles in human physiology and are involved in multiple disorders. Researchers are searching for pharmacological modulators of aquaglyceroporins as potential therapeutic strategies. Additionally, hormones and natural compounds have been identified as alternative ways to modulate aquaglyceroporins through gene and protein expression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Neurosciences
William Guiler, Addison Koehler, Christi Boykin, Qun Lu
Summary: Classical Rho GTPases, such as RhoA, Rac1, and Cdc42, play crucial roles in cellular functions and are promising targets for therapeutic intervention in neurodegenerative diseases. Pharmacological modulators targeting Rho GTPases show potential for managing conditions like Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. However, further research is needed to understand the complex modulation of Rho GTPase signaling and its implications for disease progression.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Xuan Wang, Peng Hua, Chengwei He, Meiwan Chen
Summary: Non-apoptotic cell death, such as ferroptosis, necroptosis, and pyroptosis, holds significant potential as an emerging cancer therapeutic target. Nanomedicine technology combined with different pathways and components can induce various forms of non-apoptotic cell death and achieve targeted and combination therapies.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Rodrigo F. N. Ribeiro, Claudia Cavadas, Maria Manuel C. Silva
Summary: Disruption of circadian oscillations can lead to clock-related diseases, and small-molecule modulators of the circadian clock (SMMCC) target core or noncore clock proteins to modulate physiological effects. Both established and novel SMMCCs targeting circadian proteins have potential therapeutic applications for diverse clock-related disorders, with future perspectives including clinical trials and safety considerations.
DRUG DISCOVERY TODAY
(2021)
Review
Neurosciences
Dorien A. Maas, Maria Cecilia Angulo
Summary: Enhanced neuronal activity in the healthy brain can induce new myelination and behavioral changes, showing potential for myelin repair in demyelinating disorders such as multiple sclerosis. Preclinical studies suggest that stimulating neuronal activity in demyelinated lesions can improve remyelination, but the most efficient stimulation protocols and biological mechanisms need further exploration. Clinical studies have also shown that non-invasive brain stimulation can ameliorate MS symptoms, although the exact mechanism of symptom improvement remains unclear.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Reiji Yamazaki, Yasuyuki Osanai, Tom Kouki, Jeffrey K. Huang, Nobuhiko Ohno
Summary: Multiple sclerosis (MS) is characterized by remyelination failure, axonal degeneration, and progressive worsening of motor functions. Animal models of demyelination are commonly used to develop and evaluate therapies for MS. In this study, the focal internal capsule (IC) demyelination mouse model was used to examine the effect of clemastine, an anti-muscarinic drug that promotes remyelination, on motor functions. Clemastine administration improved motor function and increased myelination in the IC lesions, suggesting that the IC demyelination model is useful for evaluating changes in motor functions following pharmacological treatments.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Marianna Greco, Marzia De Santo, Alessandra Comande, Emilia Lucia Belsito, Sebastiano Ando, Angelo Liguori, Antonella Leggio
Summary: Leptin, a multifunctional hormone primarily produced in adipose tissue, plays a crucial role in regulating various biological functions through interaction with its receptor. Abnormal levels of leptin and leptin resistance are associated with different diseases, suggesting the potential of developing leptin signaling modulators for treatment.
Letter
Clinical Neurology
Guillermo Delgado-Garcia, Emmanuel Antonio-Luna, Diego Lopez-Mena, Veronica Rivas-Alonso, Jose Flores-Rivera, Teresa Corona-Vazquez
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Clinical Neurology
Enrique Gomez-Figueroa, Guillermo Noriega-Morales, Adriana Casallas-Vanegas, Indhira Zabala-Angeles, Christian Garcia-Estrada, Daniel Neri, Adib Jorge-de Sarachaga, Veronica Rivas-Alonso, Teresa Corona-Vazquez, Jose Flores-Rivera
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)
Article
Immunology
Christian Garcia-Estrada, Adriana Casallas-Vanegas, Indhira Zabala-Angeles, Enrique Gomez-Figueroa, Veronica Rivas-Alonso, Jose Flores-Rivera
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Article
Clinical Neurology
Adriana Casallas-Vanegas, Enrique Gomez-Figueroa, Adib Jorge de Sarachaga, Indhira Zabala-Angeles, Christian Garcia-Estrada, Jorge C. Salado-Burbano, Maria Clara DiazGranados-Palacio, Teresita Corona-Vazquez, Jose de Jesus Flores-Rivera, Veronica Rivas-Alonso
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Clinical Neurology
J. L. Guerrero Camacho, T. Corona Vazquez, J. J. Flores Rivera, A. Ochoa Morales, L. Martinez Ruanoa, I. Torres Ramirez de Arellano, D. J. Davila Ortiz de Montellano, A. Jara Prado
Summary: This study aimed to determine the association between the ABCB1 gene variants (C1236T, G2677T/A, and C3435T) and demyelinating disease. The study found that the GG2677/CC3435 genotype combination was associated with demyelinating disease, particularly in men. This study revealed the significant role of the ABCB1 gene in demyelinating disease.
Review
Clinical Neurology
Edgar Carnero Contentti, Juan Ignacio Rojas, Edgardo Cristiano, Vanessa Daccach Marques, Jose Flores-Rivera, Marco Lana-Peixoto, Carlos Navas, Regina Papais-Alvarenga, Douglas K. Sato, Ibis Soto de Castillo, Jorge Correale
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Clinical Neurology
Enrique Gomez-Figueroa, Efrain Gutierrez-Lanz, Alonso Alvarado-Bolanos, Adriana Casallas-Vanegas, Christian Garcia-Estrada, Indhira Zabala-Angeles, Arturo Cadena-Fernandez, Rivas-Alonso Veronica, Trevino-Frenk Irene, Jose Flores-Rivera
Summary: Objective analysis of cyclophosphamide (CYC) treatment in patients with multiple sclerosis (MS) shows that it remains a valid therapeutic option, especially for patients with high relapsing activity and malignant disease course. The efficacy of CYC is demonstrated through stable EDSS scores, decreased progression index (PI), and reduced annualized relapse rate (ARR) over a 36-month follow-up period.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Elma M. Paredes-Aragon, Hector E. Valdez-Ruvalcaba, Andrea Santos-Peyret, Marcela Cisneros-Otero, Raul Medina-Rioja, Sandra Orozco-Suarez, Miriam M. Hernandez, Michele D. L. Breda-Yepes, Veronica Rivas-Alonso, Jose J. Flores-Rivera, Iris E. Martinez-Juarez
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
A. Ochoa-Morales, A. Fresan-Orellana, T. Hernandez-Mojica, A. Jara-Prado, T. Corona-Vazquez, J. J. Flores-Rivera, C. Y. Rito-Garcia, V Rivas-Alonso, J. L. Guerrero-Camacho, D. J. Davila-Ortiz de Montellano
Summary: The study found that the perceived discrimination in patients with multiple sclerosis is associated with early disease onset, depressive symptoms, and the lack of caregivers. It suggests that medical care and life quality improvement for this vulnerable group require greater education about the disease and the establishment of patient support programs.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Immunology
Edgar Carnero Contentti, Guillermo Delgado-Garcia, Juan Criniti, Pablo A. Lopez, Juan Pablo Pettinicchi, Edgardo Cristiano, Jimena Miguez, Edgar Patricio Correa-Diaz, Marcelo Oswaldo Alvarez Pucha, Joselyn Elizabeth Mino Zambrano, Enrique Gomez-Figueroa, Veronica Rivas-Alonso, Jose Flores-Rivera, Veronica Tkachuk, Alejandro Caride, Juan Ignacio Rojas
Summary: The neutrophil-to-lymphocyte ratio (NLR) was found to be higher in AQP4-IgG-positive NMOSD patients during attacks and follow-up, but was not an independent predictor of clinical or imaging outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Carlos D. Sanchez-Cardenas, Diana Vega-Sanchez, Sarah B. Vargas-Santana, Jose Flores-Rivera, Roberto Arenas, Teresa Corona
Summary: The frequency of onychomycosis is slightly higher in patients with MS compared to the general population, with a possible association of HLA-DR8 as a susceptibility factor. The etiology of opportunistic fungi in MS patients with onychomycosis may be related to immunosuppressive treatment.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Dumitru Ciolac, Philipp Albrecht, Patrick Kuery, Joel Gruchot, Michael Dietrich, Christina Hecker, Thomas Muentefering, Stefanie Bock, Mohammadsaleh Oshaghi, Angela Radetz, Manuela Cerina, Julia Kraemer, Lydia Wachsmuth, Cornelius Faber, Hans Lassmann, Tobias Ruck, Sven G. Meuth, Muthuraman Muthuraman, Sergiu Groppa
Summary: The enlargement of ChP is closely associated with acute disease activity in both studied mouse models and humans, suggesting it as a potential interspecies marker for neuroinflammation that relates to functional impairment. Pharmacological modulation of the blood-CSF barrier with natalizumab prevents ChP volume increase and shows a close dependency of ChP integrity on molecular signatures of neuroinflammation. These findings suggest ChP characteristics as robust and translatable hallmarks of acute and ongoing neuroinflammatory activity in mice and humans.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Moritz Forster, Christopher Nelke, Saskia Rauber, Hans Lassmann, Tobias Ruck, Maria Pia Sormani, Alessio Signori, Hans-Peter Hartung, Patrick Kury, Sven G. Meuth, David Kremer
Summary: Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system with unknown etiology. Research suggests that higher levels of nitrite/nitrate in the cerebrospinal fluid of MS patients compared to patients with noninflammatory other neurological diseases may help differentiate between the two conditions, although further studies are needed for confirmation.
Article
Clinical Neurology
Edgar Carnero Contentti, Guillermo Delgado-Garcia, Pablo A. Lopez, Juan Criniti, Juan Pablo Pettinicchi, Edgar Patricio Correa-Diaz, Ibis Soto de Castillo, Vanessa Daccach Marques, Veronica Tkachuk, Edgardo Cristiano, Gabriel Serva Braga Dieguez, Antonio Carlos dos Santos, Maria C. Castillo, Liliana Patrucco, Marcelo Oswaldo Alvarez Pucha, Joselyn Elizabeth Mino Zambrano, Enrique Gomez-Figueroa, Veronica Rivas-Alonso, Jose Flores-Rivera, Alejandro Caride, Juan Ignacio Rojas
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Letter
Psychiatry
Nora Kerik-Rotenberg, Ivan Diaz-Meneses, Rodrigo Hernandez-Ramirez, Rodrigo Munoz-Casillas, Carlos Reynoso-Mejia, Carlos Aguilar-Palomeque, Jose Flores-Rivera, Mariana Espinola-Nadurille, Jesus Ramirez-Bermudez