Article
Neurosciences
Elizabeth Nicholson, Dimitri M. Kullmann
Summary: The study demonstrates that acetylcholine release from cholinergic axons is able to trigger heterosynaptic potentiation of glutamatergic signaling to oriens interneurons in the hippocampus, independent of NMDA receptors. This phenomenon is sensitive to postsynaptic Ca2+ chelation and blockers of nicotinic receptors, highlighting the importance of cholinergic signaling in the induction of LTP.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Bert Vancura, Tristan Geiller, Andres Grosmark, Vivian Zhao, Attila Losonczy
Summary: The authors used functional imaging, electrophysiology, and molecular identification to investigate how inhibitory interneurons regulate the inhibitory control of hippocampal memory traces during learning. They found that specific populations of interneurons play a role in memory reactivation events and the generation of sharp-wave ripples (SWRs). The activity of different types of interneurons correlates with SWR duration and behavior during hippocampal-dependent learning.
NATURE NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Eunbi Cho, Se Jin Jeon, Jieun Jeon, Jee Hyun Yi, Huiyoung Kwon, Hyun-Ji Kwon, Kyoung Ja Kwon, Minho Moon, Chan Young Shin, Dong Hyun Kim
Summary: Phyllodulcin, a component of hydrangea, can inhibit the aggregation of A beta and improve memory impairments in AD mice, suggesting it may be a potential treatment for AD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Young Lee, Ming Wang, Yurim Son, Eun-Ju Yang, Moon-Seok Kang, Hyun-Joo Kim, Hyung-Seok Kim, Jihoon Jo
Summary: Avenanthramide-C from germinated oats may be beneficial for AD-related synaptic plasticity impairment and memory decline, as it has been shown to restore impaired LTP in a mouse model of AD.
Article
Neurosciences
Sam McKenzie, Roman Huszar, Daniel F. English, Kanghwan Kim, Fletcher Christensen, Euisik Yoon, Gyorgy Buzsaki
Summary: The study focuses on how incorporating synthetic hippocampal signals is constrained by preexisting circuit dynamics through optogenetic stimulation of CA1 neurons in mice. Stimulation induced persistent place field remapping and reflected circuit modification through altered spike transmission. The findings suggest that plasticity in recurrent/lateral inhibition may drive learning by rapidly associating existing states.
Article
Psychiatry
Carol Eisenberg, Deepak Subramanian, Milad Afrasiabi, Patryk Ziobro, Jack DeLucia, Pamela R. Hirschberg, Michael W. Shiflett, Vijayalakshmi Santhakumar, Tracy S. Tran
Summary: Neuropilin 2 (Nrp2) deficiency in mice leads to reduced numbers of interneuron subtypes in the hippocampus and compromised inhibition in CA1, increasing susceptibility to seizures and exhibiting behavioral deficits consistent with ASD/epilepsy phenotype.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Sebi Rolotti, Heike Blockus, Fraser T. Sparks, James B. Priestley, Attila Losonczy
Summary: The hippocampus plays a critical role in memory consolidation, particularly during sharp-wave ripple (SWR) events. This study investigated the relationship between network state and information processing in dendrites, the primary sites of synaptic input integration and plasticity. The researchers found that immobility led to increased dendritic activity, which was concentrated during SWR events. Concurrent dendritic and somatic activity during SWRs predicted increased coupling during subsequent exploration of a novel environment. Somatic-dendritic coupling and SWR recruitment also varied based on cells' tuning distance to reward location during a goal-learning task.
Article
Multidisciplinary Sciences
Jaekyung Kim, Abhilasha Joshi, Loren Frank, Karunesh Ganguly
Summary: This study investigates the dynamics of cross-area coupling between the hippocampus, prefrontal cortex, and primary motor cortex during sleep. The results reveal two distinct stages of processing, characterized by different patterns of interaction between these brain areas. The first stage is associated with rapid learning and variability of motor cortex activity, while the second stage is characterized by increased coupling between the prefrontal cortex and motor cortex and decreased coupling between the hippocampus and motor cortex. Additionally, manipulation of task parameters can re-engage the interaction between the hippocampus and motor cortex.
Article
Biotechnology & Applied Microbiology
Yingying Zha, Yan Jin, Xinxing Wang, Lin Chen, Xulai Zhang, Ming Wang
Summary: In this study, the distribution of fullerenol in the brain was confirmed using MALDI-TOF-MS, and it was found that a low dose of fullerenol could improve lead-induced impairment in learning and memory through long-term changes in hippocampal synaptic plasticity. Structural alterations in synaptic connection were observed, suggesting the therapeutic potential of fullerenol in the development of new drugs.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Yoav Rechavi, Alon Rubin, Ofer Yizhar, Yaniv Ziv
Summary: Physical exercise is known to improve memory and cognition, but little is known about its effects on neural coding. This study used calcium imaging in freely behaving mice and found that running accelerates the emergence of a more informative spatial code in new environments and increases code stability over time. Interestingly, although runners had a more stable place code overall, their code changed faster when controlling for code quality level. A combination of improved code quality and faster representational drift in runners may explain these results.
Article
Neurosciences
Eve Honore, Jean-Claude Lacaille
Summary: Hippocampus-dependent learning and memory rely on long-term synaptic changes in hippocampal networks. The activity of somatostatin interneurons is necessary for fear memory formation and object location memory formation. Optogenetic induction of synaptic long-term potentiation is sufficient to facilitate consolidation of object location memory.
Article
Neurosciences
Dylan S. Spets, Haley A. Fritch, Scott D. Slotnick
Summary: Sex differences in functional connectivity during long-term memory tasks were investigated in this study. Females showed greater interhemispheric connectivity while males showed greater intrahemispheric connectivity. The hippocampus was functionally connected to various brain regions, with differences observed between males and females in connectivity patterns.
Article
Cell Biology
Janelle M. Miranda, Emmanuel Cruz, Benjamin Bessieres, Cristina M. Alberini
Summary: Episodic memories formed in early childhood rapidly decay, but their latent traces remain stored long term. The maturation of parvalbumin interneurons (PVIs), a major mechanism of critical periods, contributes to memory development. Episodic infantile learning increases the levels of parvalbumin in the dorsal hippocampus (dHPC). These PVIs are required for infantile memory formation and are critical for memory development.
Article
Cell Biology
Junfeng Su, Fengwen Huang, Yu Tian, Ran Tian, Qianqian Gao, Stephen Temitayo Bello, Dingxaun Zeng, Peter Jendrichovsky, C. Geoffrey Lau, Wenjun Xiong, Daiguan Yu, Micky Tortorella, Xi Chen, Jufang He
Summary: This study reveals the critical role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus, affecting CA3-CA1 LTP and space-related performance.
Article
Anatomy & Morphology
Petrina Yau-Pok Lau, Linda Katona, Peter Saghy, Kathryn Newton, Peter Somogyi, Karri P. Lamsa
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Neurosciences
Alexander Kukalev, Yiu-Ming Ng, Limei Ju, Amal Saidi, Sophie Lane, Angeles Mondragon, Dirk Dormann, Sophie E. Walker, William Grey, Philip Wing-Lok Ho, David N. Stephens, Antony M. Carr, Karri Lamsa, Eric Tse, Veronica P. C. C. Yu
Article
Biochemistry & Molecular Biology
Viktor Szegedi, Melinda Paizs, Eszter Csakvari, Gabor Molnar, Pal Barzo, Gabor Tamas, Karri Lamsa
Article
Neurosciences
Inga H. Deakin, Wiebke Nissen, Amanda J. Law, Tracy Lane, Riam Kanso, Markus H. Schwab, Klaus-Armin Nave, Karri P. Lamsa, Ole Paulsen, David M. Bannerman, Paul J. Harrison
Article
Neurosciences
Diogo M. Rombo, Raquel B. Dias, Sofia T. Duarte, Joaquim A. Ribeiro, Karri P. Lamsa, Ana M. Sebastiao
Article
Neurosciences
Diogo M. Rombo, Kathryn Newton, Wiebke Nissen, Sylvia Badurek, Jacqueline M. Horn, Liliana Minichiello, John G. R. Jefferys, Ana M. Sebastiao, Karri P. Lamsa
Article
Neurosciences
Andras Szabo, Jozsef Somogyi, Bruno Cauli, Bertrand Lambolez, Peter Somogyi, Karri P. Lamsa
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Tommas J. Ellender, Joseph V. Raimondo, Agnese Irkle, Karri P. Lamsa, Colin J. Akerman
JOURNAL OF NEUROSCIENCE
(2014)
Editorial Material
Neurosciences
Dimitri M. Kullmann, Karri P. Lamsa
Editorial Material
Neurosciences
Paul J. Harrison, David Pritchett, Katharina Stumpenhorst, Jill F. Betts, Wiebke Nissen, Judith Schweimer, Tracy Lane, Philip W. J. Burnet, Karri P. Lamsa, Trevor Sharp, David M. Bannerman, Elizabeth M. Tunbridge
Article
Neurosciences
Jozsef Somogyi, Andras Szabo, Peter Somogyi, Karri Lamsa
FRONTIERS IN NEURAL CIRCUITS
(2012)
Article
Biology
Viktor Szegedi, Melinda Paizs, Judith Baka, Pal Barzo, Gabor Molnar, Gabor Tamas, Karri Lamsa
Article
Neurosciences
Dimitrios Kotzadimitriou, Wiebke Nissen, Melinda Paizs, Kathryn Newton, Paul J. Harrison, Ole Paulsen, Karri Lamsa
Article
Neurosciences
Viktor Szegedi, Gabor Molnar, Melinda Paizs, Eszter Csakvari, Pal Barzo, Gabor Tamas, Karri Lamsa