期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 311, 期 2, 页码 E508-E518出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00126.2016
关键词
gestation; exercise; offspring; glucose homeostasis; pancreas
资金
- Institut National de la Sante et de la Recherche Medicale and Structure Federative de Recherche Sport Exercice Motricite - French Ministry of Research
Only a few studies have explored the effects of maternal exercise during gestation on adult offspring metabolism. We set out to test whether maternal controlled submaximal exercise maintained troughout all gestational periods induces persistant metabolic changes in the offspring. We used a model of 15-wk-old nulliparous female Wistar rats that exercised (trained group) before and during gestation at a submaximal intensity or remained sedentary (control group). At weaning, male offspring from trained dams showed reduced basal glycemia (119.7 +/- 2.4 vs. 130.5 +/- 4.1 mg/dl, P < 0.05), pancreas relative weight (3.96 +/- 0.18 vs. 4.54 +/- 0.14 g/kg body wt, P < 0.05), and islet mean area (22,822 +/- 4,036 vs. 44,669 +/- 6,761 mu m(2), P < 0.05) compared with pups from control dams. Additionally, they had better insulin secretory capacity when stimulated by 2.8 mM glucose + 20 mM arginine compared with offspring from control dams (+96%, P < 0.05). At 7 mo of age, offspring from trained mothers displayed altered glucose tolerance (AUC = 15,285 +/- 527 vs. 11,898 +/- 988 mg.dl(-1).120 min, P < 0.05) and decreased muscle insulin sensitivity estimated by the phosphorylated PKB/ total PKB ratio (-32%, P < 0.05) and tended to have a reduced islet insulin secretory capacity compared with rats from control dams. These results suggest that submaximal maternal exercise modifies short-term male offspring pancreatic function and appears to have rather negative long-term consequences on sedentary adult offspring glucose handling.
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