Article
Cell Biology
Arthur Bassot, Helena Dragic, Sarah Al Haddad, Laurine Moindrot, Soline Odouard, Francesca Corlazzoli, Eliana Marinari, Alexandra Bomane, Augustin Brassens, Antoine Marteyn, Youssef Hibaoui, Tom J. Petty, Mounira Chalabi-Dchar, Louis Larrouquere, Evgeny M. Zdobnov, Noemie Legrand, Jerome Tamburini, Hubert Lincet, Marie Castets, Mayra Yebra, Denis Migliorini, Valerie Dutoit, Paul R. Walker, Olivier Preynat-Seauve, Pierre-Yves Dietrich, Erika Cosset
Summary: The study identified miR-17-3p, miR-222, and miR-340 as critical miRNAs for GBM patients and showed that their combinatorial modulation efficiently inhibited biological processes, induced cell death, and delayed tumor growth. This suggests that multi-targeting of miR-17-3p, miR-222, and miR-340 could be a promising therapeutic strategy for GBM patients.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Alba Corman, Oleksandra Sirozh, Vanesa Lafarga, Oscar Fernandez-Capetillo
Summary: The nucleolus is where ribosome biogenesis takes place, which is one of the most resource-intensive processes in eukaryotic cells. It is highly responsive to growth signaling and nucleolar insults, collectively known as nucleolar stress. Nucleolar alterations are a prominent feature in various human diseases, including cancer and neurodegeneration, and are also associated with aging. There have been numerous efforts to develop compounds targeting different aspects of nucleolar activity. This article provides an overview of therapeutic opportunities and current therapies for targeting nucleoli in different pathologies.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Yang Liu, Xiaohe Yang, Yali Wang, Yueying Yang, Dejuan Sun, Hua Li, Lixia Chen
Summary: SHP2 protein plays important roles in regulating inflammatory diseases, including cancer-related inflammation, neurodegenerative diseases, and metabolic diseases. The latest SHP2 inhibitors hold promise for future therapeutic potential.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Antonio Julia, Irene Bonafonte-Pardas, Antonio Gomez, Maria Lopez-Lasanta, Mireia Lopez-Corbeto, Sergio H. Martinez-Mateu, Jordi Llados, Ivan Rodriguez-Nunez, Richard M. Myers, Sara Marsal
Summary: The study proposed that blocking the CD80/86 signaling pathway could be an effective therapeutic approach to mitigate the excessive immune response in severe COVID-19, with abatacept showing potential to counteract the proinflammatory processes induced by the virus. The results suggest a significant antagonism between SARS-CoV-2 infection and COVID-19 severity with the systemic response to abatacept, supporting its candidacy as a preventive treatment for severe COVID-19.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Meng Jia, Liang Li, Ruiqi Chen, Junyao Du, Zhe Qiao, Di Zhou, Min Liu, Xiaojie Wang, Jichao Wu, Yusheng Xie, Yu Sun, Yan Zhang, Ziying Wang, Tao Zhang, Huili Hu, Jinpeng Sun, Wei Tang, Fan Yi
Summary: This study found that RNA oxidation is involved in the pathogenesis of acute kidney injury (AKI), and identified ISG20 as a novel regulator of RNA oxidation. Targeting ISG20-handled RNA oxidation may be an innovative therapeutic strategy for AKI.
Review
Oncology
Yi-Chao Zheng, Yan-Jia Guo, Bo Wang, Chong Wang, M. A. A. Mamun, Ya Gao, Hong-Min Liu
Summary: UBE2M and UBE2F are two enzymes in the NEDD8-conjugating pathway, playing important roles in posttranslational modification and potential cancer treatment targets.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Huiyan Sun, Dandan Chen, Wenjing Xin, Lixue Ren, Qiang LI, Xuchen Han
Summary: Cardiomyopathies are a group of cardiac diseases characterized by heart muscle damage, resulting in myocardium disorders and diminished cardiac function, and can lead to heart failure and sudden cardiac death. Recent studies have found that ferroptosis, an iron-dependent form of cell death, contributes to the development of various cardiomyopathies. Inhibiting ferroptosis with therapeutic compounds has shown potential in treating these conditions. This review summarizes the mechanisms by which ferroptosis leads to cardiomyopathies and highlights the beneficial effects of inhibiting ferroptosis in their treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jonghwa Jin, Jun-Kyu Byun, Yeon-Kyung Choi, Keun-Gyu Park
Summary: This review summarizes the mechanisms involved in glutamine metabolism and discusses strategies for targeting glutamine metabolism for cancer treatment. It also explores the mechanisms underlying cancer cell resistance to agents that target glutamine metabolism and strategies for overcoming resistance. Furthermore, it discusses the effects of glutamine blockade on the tumor microenvironment and explores strategies to maximize the utility of glutamine blockers as a cancer treatment.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Keisuke Yamamoto, Dosuke Iwadate, Hiroyuki Kato, Yousuke Nakai, Keisuke Tateishi, Mitsuhiro Fujishiro
Summary: Autophagy plays an important role in pancreatic ductal adenocarcinoma (PDAC). In PDAC, autophagy is constitutively active and enables the tumor to survive and thrive in a nutrient-scarce environment. Autophagy promotes PDAC progression through various mechanisms, including metabolic support, resistance to therapy, and immune evasion. Host autophagy also contributes to PDAC progression. There are ongoing clinical trials targeting the autophagy-lysosome pathway in PDAC.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Cell Biology
Yanqin Luo, Jingyang Li, Peng Yu, Jiayi Sun, Yingfan Hu, Xianli Meng, Li Xiang
Summary: Lung cancer, particularly non-small cell lung cancer (NSCLC), is a major cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs), which are non-protein-coding RNA molecules longer than 200 nucleotides, play a crucial role in the development and progression of NSCLC. Programmed cell death (PCD) is the main mechanism leading to tumor cell death in most cancer treatments, and recent studies have shown that lncRNAs are closely associated with PCD and can regulate various death pathways in NSCLC. This review focuses on the function of lncRNAs in PCD of NSCLC and summarizes the therapeutic role of targeting lncRNAs in PCD for NSCLC treatment.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Xuemei Wei, Guoqi Yu, Hualiang Shen, Yanjuan Luo, Tianbo Shang, Runpu Shen, Meiyang Xi, Haopeng Sun
Summary: Phosphodiesterase 4 (PDE4), highly expressed in mammalian brain, selectively hydrolyzes cAMP, a key regulator of brain functions such as learning and memory. Inhibiting PDE4 can improve cognitive deficits, but its clinical development is hindered by adverse effects. Research on PDE4 subtypes and the development of subtype-specific inhibitors show promise for improved therapeutic benefits and safety.
BIOORGANIC CHEMISTRY
(2023)
Review
Immunology
Hager Mohamed, Theodore Gurrola, Rachel Berman, Mackenzie Collins, Ilker K. Sariyer, Michael R. Nonnemacher, Brian Wigdahl
Summary: HIV-1 infection is a global health burden, and current drug therapies face challenges. Novel anti-HIV-1 therapies targeting CCR5 have shown promise in preventing infection and are included in gene editing techniques, CCR5 blockade using antibodies or antagonists, or combinations of both.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Wangjun Xu, Weiping Gao, Yukun Guo, Feng Xue, Lulu Di, Shaojie Fang, Linlin Fan, Yangyang He, Yunfeng Zhou, Xinmei Xie, Xiaobin Pang
Summary: This review summarizes the abnormalities and regulatory mechanisms of mitophagy in depression, and discusses various therapeutic strategies to restore mitophagy for depression alleviation.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Chen Chen, Tingting Huang, Xiaozhu Zhai, Yezhi Ma, Lv Xie, Bingwei Lu, Yueman Zhang, Yan Li, Zengai Chen, Jiemin Yin, Peiying Li
Summary: After a stroke, the intricate immune response involving various immune cells, including neutrophils, plays a crucial role in ischemic brain damage. The heterogeneity of neutrophils and their diverse roles in different conditions are still being studied, with single-cell RNA sequencing providing new insights. Potential therapeutic strategies targeting neutrophils to limit brain damage following ischemic stroke are being explored.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Yihang Pan, Xueke Wang, Xiwang Liu, Lihua Shen, Qixing Chen, Qiang Shu
Summary: Ischemia-reperfusion (I/R) injury is a significant challenge in perioperative medicine, and ferroptosis has been identified as a potential therapeutic target for this devastating disease.