Article
Endocrinology & Metabolism
Isabella Jonsson, Kirstine N. Bojsen-Moller, Viggo B. Kristiansen, Simon Veedfald, Nicolai J. Wewer Albrechtsen, Trine R. Clausen, Rune E. Kuhre, Jens F. Rehfeld, Jens J. Holst, Sten Madsbad, Maria S. Svane
Summary: The study suggests that exogenous CDCA may enhance postprandial GLP-1 and glucagon secretion in individuals who have undergone RYGB, while the BA sequestrant colesevelam may decrease these hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Marta Guimaraes, Catarina Osorio, Diogo Silva, Rui F. Almeida, Antonio Reis, Samuel Cardoso, Sofia S. Pereira, Mariana P. Monteiro, Mario Nora
Summary: The study evaluated the long-term efficacy of Roux-en-Y Gastric Bypass (RYGB) surgery by assessing weight loss and comorbidity improvement in patients 10 years or more after the surgery. Results showed a significant decrease in body mass index (BMI) and successful comorbidity remission. Although a small proportion of patients required revision surgery for weight loss failure, RYGB was confirmed as an effective primary bariatric intervention.
Article
Medicine, General & Internal
Gisele Florencio, Aglecio Souza, Elinton Chaim, Allan Santos, Louise Duran, Camila Carvalho, Sarah Monte Alegre
Summary: This study evaluated the phase angle (PhA) and sarcopenia in young individuals pre- and post-Roux-en-Y gastric bypass surgery. The results showed that the postoperative group had significantly lower PhA and higher resistance (R). Handgrip strength and gait speed were negatively correlated with R, hs-CRP, and leptin. Appendicular lean mass was negatively correlated with reactance and R. Overall, PhA and other components of bioelectrical impedance analysis were found to be correlated with sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Georgios-Ioannis Verras, Francesk Mulita, Sjaak Pouwels, Chetan Parmar, Nikolas Drakos, Konstantinos Bouchagier, Charalampos Kaplanis, George Skroubis
Summary: Morbid obesity is a chronic disease with a rising incidence, and surgical treatment has shown superior outcomes compared to conventional weight loss measures. This study evaluated the long-term weight loss outcomes, comorbidity reduction, and adverse effects of Roux-en-Y Gastric Bypass (RYGB), Biliopancreatic Diversion (BPD), and Sleeve Gastrectomy (SG) at 10 years. RYGB and BPD resulted in significant weight loss, with no observed differences in diabetes resolution and adverse outcomes. Longer follow-up reports are important for comparing the outcomes of different bariatric operations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Maria Jose Luesma, Jose Fernando, Irene Cantarero, Pilar Lucea, Sonia Santander
Summary: The prevalence of obesity has been increasing rapidly in recent decades, making it one of the most impacting diseases on global health. It is a chronic disease associated with various comorbidities that result in a reduced life expectancy and quality of life. The treatment of obesity requires a multidisciplinary approach by a specialized medical team and can be done through conservative or surgical treatments. Vertical gastrectomy, mixed techniques, and gastric bypass are the most commonly used surgical techniques. The choice of technique should consider the characteristics of each patient and the surgical team's experience.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: Transoral gastric outlet reduction (TORe) is a safe and effective treatment for post-prandial hypoglycemia and weight regain after Roux-en-Y gastric bypass (RYGB) in patients with symptoms refractory to medications and dietary changes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: TORe is a safe and effective treatment for patients with refractory symptoms of post-prandial hypoglycemia and weight regain after RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Gastroenterology & Hepatology
Nele Steenackers, Tim Vanuytsel, Patrick Augustijns, Jan Tack, Ann Mertens, Matthias Lannoo, Bart Van der Schueren, Christophe Matthys
Summary: Sleeve gastrectomy and Roux-en-Y gastric bypass have distinct effects on gastrointestinal physiology, such as accelerating gastric emptying and increasing bile acid serum levels. However, their effects on other aspects remain largely unknown.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Samuel Klein, Randy J. Seeley
Summary: Many individuals with obesity and type 2 diabetes experience diabetes remission after Roux-en-Y gastric bypass surgery, but there is disagreement regarding the underlying mechanisms. We present our perspective on conflicting datasets suggesting that the remission could be attributed solely to weight loss or weight loss-independent factors.
Article
Surgery
Fulya Calikoglu, Umut Barbaros, Ayse Kubat Uzum, Yildiz Tutuncu, Ilhan Satman
Summary: The study evaluated the effectiveness of early use of pre-probiotics after Roux-en-Y gastric bypass (RYGB). It was found that early postoperative use of pre-probiotics enhanced insulin, GLP-1, and PYY secretion, but negatively affected anthropometric measurements and appetite ratings. Further research is needed to determine if late postoperative use of pre-probiotics may be more effective for patients with weak insulin and incretin response.
Article
Surgery
Robert A. Li, Liyan Liu, David Arterburn, Karen J. Coleman, Anita P. Courcoulas, David Fisher, Sebastien Haneuse, Eric Johnson, Mary Kay Theis, Tae K. Yoon, Heidi Fisher, James R. Fraser, Lisa J. Herrinton
Summary: This study compared the long-term risks of reintervention following sleeve gastrectomy and Roux-en-Y gastric bypass, and found that sleeve gastrectomy was associated with significantly lower risk of reintervention in all categories at the 5-year follow-up. Patients undergoing sleeve gastrectomy had better outcomes in subsequent interventions when compared with those undergoing Roux-en-Y gastric bypass.
Article
Endocrinology & Metabolism
Ibiyemi Ilesanmi, George Tharakan, Kleopatra Alexiadou, Preeshila Behary, Haya Alessimii, Candace Bovill-Taylor, Julia Kenkre, Sirazum Choudhury, Chedie Doyle, Sanjay Purkayastha, Alex Miras, Christos Tsironis, Harvinder Chahal, Stephen R. Bloom, Nick S. Oliver, Ahmed R. Ahmed, Bernard Khoo, Tricia M. -M. Tan
Summary: This study showed that after RYGB surgery, patients experienced a decrease in mean glucose levels, an increase in glycemic variability, and an increase in GLP-1 response, which put them at risk for postbariatric hypoglycemia.
Article
Endocrinology & Metabolism
Yuan Liang, Ruili Yu, Rui He, Lijun Sun, Chao Luo, Lu Feng, Hong Chen, Yue Yin, Weizhen Zhang
Summary: This study investigated the role of ghrelin in weight reduction and glycemic and lipid control after Roux-en-Y gastric bypass surgery. The results showed that gastric and circulating ghrelin levels significantly increased after the surgery. However, lowering ghrelin levels did not affect the metabolic benefits induced by the surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Michael O'Laughlin, Jorge Cornejo, Alba Zevallos, Alisa Coker, Michael Schweitzer, Gina Adrales, Christina Li, Raul Sebastian
Summary: Background: The rates of secondary bariatric surgery have increased, with sleeve gastrectomy to gastric bypass conversion being the most common. This study evaluates the outcomes of this conversion compared to primary Roux-en-Y gastric bypass (RYGB) surgery using MBSAQIP data. Methods: The study analyzed the data of patients who underwent sleeve gastrectomy to RYGB conversion and primary laparoscopic RYGB, matching them based on preoperative characteristics. Results: The analysis showed that the conversion from sleeve gastrectomy to RYGB was associated with higher readmissions, interventions, conversion to open surgery, longer hospital stay, and longer operative time compared to primary RYGB. However, there were no significant differences in mortality or rates of bariatric complications. Conclusion: The study concludes that conversion from sleeve gastrectomy to RYGB is a safe and feasible procedure with reasonable outcomes compared to primary RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Louise L. Stentebjerg, Lene R. Madsen, Rene K. Stoving, Lise Lotte T. Andersen, Christina A. Vinter, Claus B. Juhl, Dorte M. Jensen
Summary: This study aimed to investigate glucose metabolism during pregnancy in women who had undergone Roux-en-Y gastric bypass (RYGB). The study found that women with RYGB were more susceptible to hypoglycemia and hyperglycemia compared with control participants. Further research is needed to explore the association between hypoglycemia and fetal growth restriction in women with RYGB.