Article
Environmental Sciences
Xuanfeng Zhu, Min Sun, Hongmei Guo, Gan Lu, Jianhua Gu, Lingling Zhang, Licheng Shi, Jia Gao, Dandan Zhang, Wenjun Wang, Jiannan Liu, Xia Wang
Summary: This study demonstrates that verbascoside can exert cardioprotective effects in septic heart injury by inhibiting oxidative stress, inflammation, and apoptosis, as well as promoting mitochondrial biogenesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Zhujun Yi, Yilin Wu, Wenfeng Zhang, Tao Wang, Jianping Gong, Yao Cheng, Chunmu Miao
Summary: The PKM2 small-molecule agonist TEPP-46 activates PKM2 by inducing the formation of PKM2 tetramer and promotes macrophage endotoxin tolerance. TEPP-46-induced mitochondrial biogenesis in macrophages plays a key role in mediating endotoxin tolerance. Targeting PKM2 may provide a new therapeutic option for sepsis and inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Keliang Xie, Yaoqi Wang, Lijun Yin, Yuzun Wang, Hongguang Chen, Xing Mao, Guolin Wang
Summary: Hydrogen gas therapy improves mitochondrial function and cognitive function in septic mice with SAE by activating PGC-1 alpha, thereby increasing survival rates.
Article
Critical Care Medicine
Scott L. Weiss, Sarah E. Henrickson, Robert B. Lindell, Laura F. Sartori, Donglan Zhang, Jenny Bush, Sumera Farooqi, Jonathan Starr, Clifford S. Deutschman, Francis X. McGowan, Lance Becker, Florin Tuluc, E. John Wherry, Martin Picard, Douglas C. Wallace
Summary: This study aimed to investigate how changes in immune cell composition affect PBMC mitochondrial respiration and content in children with and without sepsis. The results showed that PBMC mitochondrial measurements varied with changes in immune cell composition in both groups, but the differences between sepsis patients and controls were partly due to the effects of sepsis itself rather than solely an epiphenomena of variable immune cell composition.
Article
Critical Care Medicine
Wei Huang, Xiaoting Wang, Hongmin Zhang, Guangjian Wang, Fang Xie, Dawei Liu
Summary: The study investigated the feasibility and value of using mitochondrial quality control-related proteins as biomarkers in septic patients. The levels of these proteins were significantly correlated with organ dysfunction and reflected disease progression and severity, providing important predictive and guidance value for outcome and treatment.
Article
Critical Care Medicine
Leijing Yin, Yuting Tang, Zhengyang Luo, Ludong Yuan, Xiaofang Lin, Shuxin Wang, Pengfei Liang, Bimei Jiang
Summary: The study aimed to investigate the protective role of nucleolin (NCL) in lipopolysaccharide (LPS)-induced myocardial injury from the aspect of mitochondrial biogenesis. The study found that NCL could protect cardiomyocytes from LPS-induced injury by promoting the gene expression of PGC-1a and mitochondrial biogenesis.
Article
Immunology
Yosuke Suzuki, Daisuke Kami, Toshihiko Taya, Arata Sano, Takehiro Ogata, Satoaki Matoba, Satoshi Gojo
Summary: Despite the development of antimicrobial agents and elaborate strategies, polymicrobial sepsis still has a high mortality rate. Mitochondrial dysfunction serves as the basis of pathogenesis. This study investigated the efficacy of a PGC1 alpha agonist called ZLN005 and found that it significantly improved overall survival in an animal model of sepsis. The mechanism of action involved enhanced mitochondrial respiratory capacity, increased function of TFEB, and improved physical contact between mitochondria and lysosomes. ZLN005 supported immune defense by increasing lysosome volume and acidity, resulting in a significant reduction in bacterial load.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jia Guo, Feng Zhou, Zhi Liu, Yuan Cao, Wanming Zhao, Zheru Zhang, Qiming Zhai, Yan Jin, Bei Li, Fang Jin
Summary: Combining exosomes with dental pulp stem cells (DPSCs) has a remarkable effect on bone regeneration. Exosomes promote osteogenic differentiation of DPSCs by transferring mitochondrial transcription factor A (TFAM) mRNA and enhancing glutamate metabolism and oxidative phosphorylation (OXPHOS) activity. This study provides a new potential strategy to improve DPSC-based bone regenerative treatment.
CELL PROLIFERATION
(2022)
Article
Medicine, Research & Experimental
Yiyi Zhu, Weiwei Gui, Bowen Tan, Ying Du, Jiaqiang Zhou, Fang Wu, Hong Li, Xihua Lin
Summary: The study discovered that IGF2 expression in skeletal muscle cells is influenced by exercise training, and IGF2 plays a crucial role in the function of skeletal muscle cells, with a lack of IGF2 leading to decreased mitochondrial function. Through the regulatory pathway of IGF2-SIRT1-PGC1α, mitochondrial regulation in skeletal muscle cells may be achieved.
Article
Critical Care Medicine
Maria Cielito Robles, Tiffany C. Heard, Tony Chao, Karl Alcover, Amanda Wagner, Kevin S. Akers, David M. Burmeister
Summary: This study found that mitochondrial DNA (mtDNA) may have diagnostic value for burn sepsis, while peripheral blood mononuclear cells (PBMC) respirometry can be used to predict the mortality rate in burn patients. However, further research is needed to validate the effectiveness of mtDNA and PBMC respirometry as biomarkers for the diagnosis and prognosis of burn sepsis.
Article
Multidisciplinary Sciences
Tzu-Huai Lin, Dana M. Bis-Brewer, Amy E. Sheehan, Louise N. Townsend, Daniel C. Maddison, Stephan Zuchner, Gaynor A. Smith, Marc R. Freeman
Summary: This study found that TSG101 inhibits mitochondrial biogenesis in axons, which is crucial for maintaining mitochondrial numbers and sizes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Dijoia B. Darden, Gabriela L. Ghita, Zhongkai Wang, Julie A. Stortz, Maria-Cecilia Lopez, Michael C. Cox, Russell B. Hawkins, Jaimar C. Rincon, Lauren S. Kelly, Brittany P. Fenner, Tezcan Ozrazgat-Baslanti, Christiaan Leeuwenburgh, Azra Bihorac, Tyler J. Loftus, Frederick A. Moore, Scott C. Brakenridge, Henry Baker, Rhonda Bacher, Alicia M. Mohr, Lyle L. Moldawer, Philip A. Efron
Summary: The study found that sepsis survivors have unique blood leukocyte transcriptomes in late sepsis, indicating ongoing immune dyscrasia which could help understand the prognosis of sepsis patients with CCI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sabrina Geisberger, Hendrik Bartolomaeus, Patrick Neubert, Ralf Willebrand, Christin Zasada, Thomas Bartolomaeus, Victoria McParland, Dries Swinnen, Anneleen Geuzens, Andras Maifeld, Luka Krampert, Marion Vogl, Anja Mahler, Nicola Wilck, Lajos Marko, Ekin Tilic, Sofia K. Forslund, Katrina J. Binger, Johannes Stegbauer, Ralf Dechend, Markus Kleinewietfeld, Jonathan Jantsch, Stefan Kempa, Dominik N. Mueller
Summary: Research shows that high salt intake leads to intracellular sodium accumulation, inhibiting mitochondrial respiration in macrophages and affecting immune cell function. While these changes may help resolve bacterial infections, they could also accelerate the development of inflammatory cardiovascular diseases.
Article
Respiratory System
Jia-yu Mao, Dong-kai Li, Hong-min Zhang, Xiao-ting Wang, Da-wei Liu
Summary: Elevated plasma mtDNA levels within 24 hours after admission were significantly associated with ALI incidence and mortality in septic patients. Patients with high mtDNA levels had worse outcomes, and increased mtDNA levels were seen in patients with abdominal infection.
BMC PULMONARY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tian Zhao, Jiaojiao Zhang, Hong Lei, Yuanyuan Meng, Hongcheng Cheng, Yanping Zhao, Guangfeng Geng, Chenglong Mu, Linbo Chen, Qiangqiang Liu, Qian Luo, Chuanmei Zhang, Yijia Long, Jingyi Su, Yinhao Wang, Zhuoya Li, Jiaxing Sun, Guo Chen, Yanjun Li, Xudong Liao, Yingli Shang, Gang Hu, Quan Chen, Yushan Zhu
Summary: This study demonstrates that viruses exploit mitochondrial biogenesis to counteract innate antiviral immunity. NRF1 is essential for virus-induced mitochondrial biogenesis and its deficiency enhances innate immunity. Virus-induced inhibition of NRF1-mediated mitochondrial biogenesis aggravates mitochondrial damage, promotes mtDNA release, increases mtROS production, and activates innate immune response.
Review
Veterinary Sciences
Lingye Chen, Karen E. Welty-Wolf, Bryan D. Kraft
Article
Multidisciplinary Sciences
Aaditya Khatri, Bryan D. Kraft, Purushothama Rao Tata, Scott H. Randell, Claude A. Piantadosi, Ann Marie Pendergast
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Medicine, General & Internal
Bruce C. Trapnell, Yoshikazu Inoue, Francesco Bonella, Cliff Morgan, Stephane Jouneau, Elisabeth Bendstrup, Ilaria Campo, Spyros A. Papiris, Etsuro Yamaguchi, Erdogan Cetinkaya, Mikhail M. Ilkovich, Mordechai R. Kramer, Marcel Veltkamp, Michael Kreuter, Tomohisa Baba, Cecilia Ganslandt, Inge Tarnow, Grant Waterer, Taneli Jouhikainen
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Bryan D. Kraft, Kamran Mahmood, Nicole P. Harlan, Matthew G. Hartwig, Laurie D. Snyder, Hagir B. Suliman, Scott L. Shofer
Summary: A study comparing hyperbaric oxygen therapy (HBOT) and usual care in patients with extensive airway necrosis after lung transplantation found that HBOT did not reduce the incidence of central airway stenosis (CAS). However, elevated expression of HIF genes in donor tissues and increased levels of HMOX1 and VEGFA were associated with the development of CAS or the need for stenting.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Critical Care Medicine
Juan Pablo Domecq, Amos Lal, Christopher R. Sheldrick, Vishakha K. Kumar, Karen Boman, Scott Bolesta, Vikas Bansal, Michael O. Harhay, Michael A. Garcia, Margit Kaufman, Valerie Danesh, Sreekanth Cheruku, Valerie M. Banner-Goodspeed, Harry L. Anderson, Patrick S. Milligan, Joshua L. Denson, Catherine A. St Hill, Kenneth W. Dodd, Greg S. Martin, Ognjen Gajic, Allan J. Walkey, Rahul Kashyap
Summary: This study aimed to describe the outcomes of hospitalized patients with COVID-19 in a multicenter, international registry. Age and type of organ support therapies were found to affect the prognosis of patients, with significant variations in hospital mortality and discharge rates among different groups receiving organ support therapies. Interhospital variation in mortality of mechanically ventilated patients was not solely attributed to patient characteristics, suggesting the need for further evaluation.
CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Micah T. McClain, Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, Elizabeth Petzold, Bradly P. Nicholson, Robert Rolfe, Bryan D. Kraft, Matthew S. Kelly, Daniel R. Saban, Chen Yu, Xiling Shen, Emily M. Ko, Gregory D. Sempowski, Thomas N. Denny, Geoffrey S. Ginsburg, Christopher W. Woods
Summary: In this study, McClain et al. used RNA sequencing to compare the peripheral blood transcriptome of subjects with SARS-CoV-2 and other respiratory infections. They found dysregulated immune responses in COVID-19 with both heterogeneous and conserved components.
NATURE COMMUNICATIONS
(2021)
Article
Physiology
Lingye Chen, Bryan D. Kraft, Victor L. Roggli, Zachary R. Healy, Christopher W. Woods, Ephraim L. Tsalik, Geoffrey S. Ginsburg, David M. Murdoch, Hagir B. Suliman, Claude A. Piantadosi, Karen E. Welty-Wolf
Summary: Based on a baboon model, this study found that heparin-based blood purification significantly reduced levels of circulating S. pneumoniae DNA and cytokines, providing renal protection in severe pneumococcal pneumonia and septic shock. The purification was also associated with less severe acute kidney injury, metabolic disorders, and shock, supporting its potential for future clinical studies in critically ill septic patients.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jacob T. Heggestad, David S. Kinnamon, Lyra B. Olson, Jason Liu, Garrett Kelly, Simone A. Wall, Solomon Oshabaheebwa, Zachary Quinn, Cassio M. Fontes, Daniel Y. Joh, Angus M. Hucknall, Carl Pieper, Jack G. Anderson, Ibtehaj A. Naqvi, Lingye Chen, Loretta G. Que, Thomas Oguin, Smita K. Nair, Bruce A. Sullenger, Christopher W. Woods, Thomas W. Burke, Gregory D. Sempowski, Bryan D. Kraft, Ashutosh Chilkoti
Summary: The microfluidic point-of-care test can profile antibody responses against multiple SARS-CoV-2 antigens and detect the prognostic biomarker IP-10, making it essential for COVID-19 management. Its high sensitivity, specificity, and diagnostic and tracking capabilities for severe patients, along with the ability to be globally deployed, make it a valuable tool in combating COVID-19.
Article
Medicine, Research & Experimental
Hyung J. Chun, Elias Coutavas, Alexander Pine, Alfred Lee, Vanessa Yu, Marcus Shallow, Coral X. Giovacchini, Anne Mathews, Brian Stephenson, Loretta G. Que, Patty J. Lee, Bryan D. Kraft
Summary: This study found that biological factors related to neutrophil activation, fibrosis signaling, and alveolar repair may be novel therapeutic or prognostic targets for individuals recovering from COVID-19 with persistent respiratory symptoms.
Review
Urology & Nephrology
Dominic C. Grimberg, Rohit Tejwani, Armand Allkanjari, Michael T. Forrester, Bryan D. Kraft, Deborah R. Kaye
Summary: Initially considered a respiratory disease, COVID-19's hypercoagulable state has been linked to various clinical complications. This case report highlights a rare occurrence of ischemic priapism in a COVID-19 patient and outlines a management approach for detumescence during proning to maintain penile circulation.
JOURNAL OF CLINICAL UROLOGY
(2021)
Article
Anesthesiology
Lyra B. Olson, Ibtehaj A. Naqvi, Daniel J. Turner, Sarah A. Morrison, Bryan D. Kraft, Lingye Chen, Bruce A. Sullenger, Smita K. Nair, Loretta G. Que, Jerrold H. Levy
Summary: This case illustrates a delicate balance between leukemia and COVID-19, where neutropenia may protect the lungs from inflammatory damage but also alter viral clearance ability. Multiple analyses were conducted to characterize coagulation and immune responses in a 53-year-old man with acute leukemia and COVID-19 who developed thrombotic complications and acute respiratory distress syndrome.
Meeting Abstract
Critical Care Medicine
B. D. Kraft, H. B. Suliman, E. N. Pavlisko, V. L. Roggli, C. A. Piantadosi
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Meeting Abstract
Critical Care Medicine
L. Chen, B. D. Kraft, V. L. Roggli, H. Suliman, C. A. Piantadosi, K. E. Welty-Wolf
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Medicine, Research & Experimental
Laura E. Fredenburgh, Mark A. Perrella, Diana Barragan-Bradford, Dean R. Hess, Elizabeth Peters, Karen E. Welty-Wolf, Bryan D. Kraft, R. Scott Harris, Rie Maurer, Kiichi Nakahira, Clara Oromendia, John D. Davies, Angelica Higuera, Kristen T. Schiffer, Joshua A. Englert, Paul B. Dieffenbach, David A. Berlin, Susan Lagambina, Mark Bouthot, Andrew Sullivan, Paul F. Nuccio, Mamary T. Kone, Mona J. Malik, Maria Angelica Pabon Porras, Eli Finkelsztein, Tilo Winkler, Shelley Hurwitz, Charles N. Serhan, Claude A. Piantadosi, Rebecca M. Baron, B. Taylor Thompson, Augustine M. K. Choi