Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

(2015) Michael E. Walsh et al.   AGING CELL

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PGC-1αgene transfer improves muscle function in dystrophic muscle following prolonged disease progress

(2015) Katrin Hollinger et al.   EXPERIMENTAL PHYSIOLOGY

PGC-1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization

(2015) Chounghun Kang et al.   FASEB JOURNAL

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

(2015) Yu-Chou Tseng et al.   JNCI-Journal of the National Cancer Institute

Butyrate prevents muscle atrophy after sciatic nerve crush

(2015) Michael E. Walsh et al.   MUSCLE & NERVE

Muscle wasting in disease: molecular mechanisms and promising therapies

(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

(2015) Yu-Chou Tseng et al.   JNCI-Journal of the National Cancer Institute

Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease

(2015) Sofia Esteves et al.   PLoS One

HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling

(2014) Kimberly M. Demos-Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

(2014) A. W. Beharry et al.   JOURNAL OF CELL SCIENCE

PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice

(2014) Jessica Cannavino et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia

(2013) Daniel J. Ham et al.   CLINICAL NUTRITION

Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas

(2013) Junwei Li et al.   EMBO Molecular Medicine

A Positive Regulatory Domain in CCAAT/Enhancer Binding Protein β (C/EBPβ) Is Required for the Glucocorticoid-Mediated Displacement of Histone Deacetylase 1 (HDAC1) from theC/ebpα Promoter and Maximum Adipogenesis

(2013) Houssein-Salem Abdou et al.   ENDOCRINOLOGY

Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia

(2013) Melissa J. Puppa et al.   FASEB JOURNAL

Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential

(2013) H.Q. Han et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Muscle wasting in cancer

(2013) N. Johns et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transcriptional and Translational Regulation of C/EBPβ-HDAC1 Protein Complexes Controls Different Levels of p53, SIRT1, and PGC1α Proteins at the Early and Late Stages of Liver Cancer

(2013) Jingling Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors

(2013) Han Fang Teng et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Resistance after Chronic Application of the HDAC-Inhibitor Valproic Acid Is Associated with Elevated Akt Activation in Renal Cell Carcinoma In Vivo

(2013) Eva Juengel et al.   PLoS One

miR-206 Represses Hypertrophy of Myogenic Cells but Not Muscle Fibers via Inhibition of HDAC4

(2013) Catherine E. Winbanks et al.   PLoS One

Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting

(2012) Sudarsanareddy Lokireddy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Myostatin is a novel tumoral factor that induces cancer cachexia

(2012) Sudarsanareddy Lokireddy et al.   BIOCHEMICAL JOURNAL

Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia

(2012) K. T. Murphy et al.   Disease Models & Mechanisms

Acetylation and deacetylation—novel factors in muscle wasting

(2012) Nima Alamdari et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

p38β MAPK upregulates atrogin1/MAFbx by specific phosphorylation of C/EBPβ

(2012) Guohua Zhang et al.   Skeletal Muscle

Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins

(2011) Sudarsanareddy Lokireddy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting

(2011) Guohua Zhang et al.   EMBO JOURNAL

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

(2011) Liping Zhang et al.   FASEB JOURNAL

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

(2011) Sarah A. Reed et al.   FASEB JOURNAL

C/EBPβ regulates dexamethasone-induced muscle cell atrophy and expression of atrogin-1 and MuRF1

(2011) Patricia Gonnella et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Retraction: Myostatin Induces Degradation of Sarcomeric Proteins through a Smad3 Signaling Mechanism During Skeletal Muscle Wasting

(2011) Sudarsanareddy Lokireddy et al.   MOLECULAR ENDOCRINOLOGY

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(2011) Silvia Consalvi et al.   MOLECULAR MEDICINE

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Valproic Acid Activates the PI3K/Akt/mTOR Pathway in Muscle and Ameliorates Pathology in a Mouse Model of Duchenne Muscular Dystrophy

(2009) Praveen B. Gurpur et al.   AMERICAN JOURNAL OF PATHOLOGY

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Deacetylase Inhibitors Modulate the Myostatin/Follistatin Axis without Improving Cachexia in Tumor-Bearing Mice

(2009) A. Bonetto et al.   CURRENT CANCER DRUG TARGETS

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

(2009) N. K. LeBrasseur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Inhibition of Atrogin-1/MAFbx Mediated MyoD Proteolysis Prevents Skeletal Muscle Atrophy In Vivo

(2009) Julie Lagirand-Cantaloube et al.   PLoS One

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL