β-Glucan successfully stimulated the immune system in different jawed vertebrate species

Several reports have shown the positive effects of beta-glucans on the immune. Howeverthese studies have a broad experimental design including beta-glucans compounds. Consequently, a study using the same beta-glucan molecule, administration route and experimental design is needed to compare the effects of beta-glucan across vertebrate species. For this end, during 28 days we fed four different vertebrate species: mice, dogs, piglets and chicks, with two beta-glucan molecules (BG01 and BG02). We measured the serum interleukin 2 as an indicator of innate immune response, the neutrophils and monocytes phagocytosis index as a cellular response and antibody formation as an adaptive response. The results clearly showed that the different beta-glucan molecules exhibited biologically differently behaviors, but both molecules stimulate the immune system in a similar pattern in these four species. This finding suggests that vertebrates shared similar mechanisms/patterns in recognizing the beta-glucans and confirms the benefits of beta-glucans across different vertebrate species.