Article
Gastroenterology & Hepatology
Benoit Chassaing, Charlene Compher, Brittaney Bonhomme, Qing Liu, Yuan Tian, William Walters, Lisa Nessel, Clara Delaroque, Fuhua Hao, Victoria Gershuni, Lillian Chau, Josephine Ni, Meenakshi Bewtra, Lindsey Albenberg, Alexis Bretin, Liam McKeever, Ruth E. Ley, Andrew D. Patterson, Gary D. Wu, Andrew T. Gewirtz, James D. Lewis
Summary: In healthy adults, consumption of the synthetic emulsifier CMC was found to exacerbate postprandial abdominal discomfort, disrupt gut microbiota and metabolome composition, leading to reduced diversity, and possibly contributing to the development of chronic inflammatory diseases.
Article
Gastroenterology & Hepatology
David C. Montrose, Ryohei Nishiguchi, Srijani Basu, Hannah A. Staab, Xi Kathy Zhou, Hanhan Wang, Lingsong Meng, Melanie Johncilla, Juan R. Cubillos-Ruiz, Diana K. Morales, Martin T. Wells, Kenneth W. Simpson, Shiying Zhang, Belgin Dogan, Chen Jiao, Zhangjun Fei, Akihiko Oka, Jeremy W. Herzog, R. Balfour Sartor, Andrew J. Dannenberg
Summary: Excessive dietary fructose consumption exacerbates colitis by altering the composition, distribution, and metabolic function of resident enteric microbiota, leading to increased access of gut luminal microbes to the colonic mucosa, reduced protective commensal microbes, and increased luminal conjugated bile acids, all of which worsen colitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Bret M. Rust, Matthew J. Picklo, Lin Yan, Aaron A. Mehus, Huawei Zeng
Summary: Time-restricted feeding is an effective method to reduce the risk of obesity-related metabolic diseases by altering nutrient absorption, fecal microbiome, and lipidome. The study found that different feeding timing and fat content can affect fecal fatty acid levels and the composition of microbiota.
Article
Gastroenterology & Hepatology
Arthur Kastl, Wenjing Zong, Victoria M. Gershuni, Elliot S. Friedman, Ceylan Tanes, Adoma Boateng, William J. Mitchell, Kathleen O'Connor, Kyle Bittinger, Natalie A. Terry, Christina Bales, Lindsey Albenberg, Gary D. Wu
Summary: This study investigates the effect of dietary fiber on patients with short bowel syndrome (SBS) and finds that SBS patients have lower diversity in their gut microbiota, which is inversely correlated with whole food consumption. Whole food intake is associated with increased glycoside hydrolases (GH) and bile salt hydrolases (BSH) and reduced fecal conjugated bile acids. Dietary fiber may regulate bile acid metabolism through the activity of gut microbiota enzymes, leading to intolerance of whole food in SBS patients.
Article
Gastroenterology & Hepatology
Kelly M. Jardon, Emanuel E. Canfora, Gijs H. Goossens, Ellen E. Blaak
Summary: Accumulating evidence suggests that the gut microbiome plays a crucial role in regulating body weight, glucose and lipid metabolism, and inflammatory processes. Differences in baseline gut microbiota composition and functionality may contribute to varying responses to dietary interventions. However, the relationship between an individual's diet, gut microbiome, and host metabolism is complex, presenting challenges for targeted dietary guidelines.
Article
Nutrition & Dietetics
Lin Song, Jiaqi Cui, Shuyuan Hu, Rui Wang, Hongbao Li, Bo Sun
Summary: A maternal high-fat diet has long-term adverse effects on offspring, but these effects can be ameliorated by maternal metformin treatment. This study found that maternal high-fat diet caused dysbiosis of gut microbiota, leading to colonic inflammation and gut barrier disruption. However, maternal metformin treatment reversed this dysbiosis and improved the metabolic phenotype of the offspring.
Article
Oncology
Soeren Ocvirk, Stephen J. D. O'Keefe
Summary: The risk of colorectal cancer is primarily influenced by environmental factors, particularly diet. High dietary fat intake is associated with the formation of pre-neoplastic lesions and colonic tumorigenesis, mainly due to its effects on gut microbiota composition and metabolism, especially in relation to bile acids. Alterations in bile acid metabolism, linked to fat-mediated changes in gut microbiota, are implicated in CRC risk and tumorigenesis by influencing intestinal and hepatic cross-signaling.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cengiz Callender, Ilias Attaye, Max Nieuwdorp
Summary: Cardio-metabolic diseases are major health issues worldwide, and there is a complex relationship between bile acids and the gut microbiome in relation to these diseases.
Review
Biochemistry & Molecular Biology
Pradipta Paul, Ridhima Kaul, Ali Chaari
Summary: The study found that probiotics, prebiotics, and synbiotics may have potential in ameliorating renal health degradation in diabetic patients, but larger and more convincing trials with focused objectives are needed, along with exploration of next-generation nutraceutical formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Gangzheng Wang, Xianglian Chen, Chengyuan Sun, Qiuju Huang, Chenghua Zhang, Min Lin, Jianping Xu, Xueshuang Huang, Wangqiu Deng
Summary: Poria cocos has beneficial health effects by modulating gut microbiota and metabolites, which can alleviate obesity and related complications.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Fusheng Xu, Zhiming Yu, Yaru Liu, Ting Du, Leilei Yu, Fengwei Tian, Wei Chen, Qixiao Zhai
Summary: Patients with post-cholecystectomy often experience adverse gastrointestinal conditions, and an epidemiological survey suggests that the risk of cholecystectomy is associated with high-fat and high-cholesterol dietary intake. Mounting evidence shows that cholecystectomy is associated with disrupted gut microbial homeostasis and dysregulated bile acids metabolism. However, the effect of an HFHC diet on gastrointestinal complications after cholecystectomy has not been elucidated.
Article
Cardiac & Cardiovascular Systems
Huanan Shi, Bojun Zhang, Taylor Abo-Hamzy, James W. Nelson, Chandra Shekar R. Ambati, Joseph F. Petrosino, Robert M. Jr Jr Bryan, David J. Durgan
Summary: Recent studies have shown that intermittent fasting can alter the gut microbiota and reduce blood pressure, while identifying microbial influenced metabolites as potential mediators in the regulation of host blood pressure.
CIRCULATION RESEARCH
(2021)
Article
Fisheries
Yanpeng Zhang, Hexiong Feng, Xu-Fang Liang, Shan He, Jie Lan, Ling Li
Summary: The study investigates the effects of dietary bile acids supplementation on lipid metabolism and gut health of Chinese perch. The results show that dietary BAs supplementation can reduce liver lipid deposition and improve gut health by regulating gut microbiota.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiamiao Hu, Peiying Zheng, Jinhui Qiu, Qingyan Chen, Shaoxiao Zeng, Yi Zhang, Shaoling Lin, Baodong Zheng
Summary: High-amylose corn starch, as a resistant starch, can regulate gut microbiota and circulating bile acids, which may be the underlying mechanisms of its anti-obesity activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carlos J. Garcia, Vit Kosek, David Beltran, Francisco A. Tomas-Barberan, Jana Hajslova
Summary: This study evaluated the diversity of microbially conjugated bile acids (MCBAs) produced by the gut microbiota through a metabolomics approach. The results showed that the gut microbiota can produce various MCBAs and re-conjugate hydroxyls on the sterol backbone as well as generate esters at the C24 acyl site of bile acids.
Article
Gastroenterology & Hepatology
Jeffrey Lazarus, Henry E. Mark, Massimo Colombo, Sandro Demaio, John F. Dillon, Jacob George, Hannes Hagstroem, Samantha Hocking, Nancy Lee, Mark J. Nieuwenhuijsen, Mary E. Rinella, Manuel Romero-Gomez, Joan B. Soriano, Joern M. Schattenberg, Frank Tacke, Emmanuel A. Tsochatzis, Luca Valenti, Shira Zelber-Sagi, M. Ashworth Dirac, Terry T-K Huang
Summary: The research team developed a framework for addressing NAFLD using the sustainable development goals as a base, with 16 targets and 7 indicators selected through a rigorous process. This framework covers a wide range of factors and can guide stakeholders in addressing the challenges of NAFLD effectively.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Zhenhuang Zhuang, Nan Li, Jiayi Wang, Ruotong Yang, Wenxiu Wang, Zhonghua Liu, Tao Huang
Summary: This study investigated the causal relationships between gut microbiota, metabolites, and inflammatory bowel disease (IBD), and found that taurine and betaine play key roles in the pathogenesis of IBD.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Jeffrey Lazarus, Henry E. Mark, Quentin M. Anstee, Juan Pablo Arab, Rachel L. Batterham, Laurent Castera, Helena Cortez-Pinto, Javier Crespo, Kenneth Cusi, M. Ashworth Dirac, Sven Francque, Jacob George, Hannes Hagstrom, Terry T-K Huang, Mona H. Ismail, Achim Kautz, Shiv Kumar Sarin, Rohit Loomba, Veronica Miller, Philip N. Newsome, Michael Ninburg, Ponsiano Ocama, Vlad Ratziu, Mary Rinella, Diana Romero, Manuel Romero-Gomez, Jorn M. Schattenberg, Emmanuel A. Tsochatzis, Luca Valenti, Vincent Wai-Sun Wong, Yusuf Yilmaz, Zobair M. Younossi, Shira Zelber-Sagi
Summary: Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects a significant portion of the global adult population, but has received little attention from the global public health community. This has led to a lack of inclusion of NAFLD in national and international strategies and policies for non-communicable diseases, highlighting the need for a more comprehensive public health response to the disease.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Pediatrics
Karen R. Florez, Sophia E. Day, Terry T-K Huang, Kevin J. Konty, Emily M. D'Agostino
Summary: Research on Latino children has shown that obesity risk varies based on place of birth, with US-born children having the highest risk and immigrant Latino children exhibiting an advantage. This highlights the importance of considering place of birth in addressing obesity prevention among Latino children.
Article
Cardiac & Cardiovascular Systems
Yimin Zhao, Duo Li, Tao Huang
Summary: This study aimed to investigate the associations between flavonoid intake and total and cardiovascular mortality in older participants. The results showed that high flavonoid intake was associated with lower mortality rates in older adults.
Article
Peripheral Vascular Disease
Xuanming Hong, Ke Miao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
Summary: This study identified CpG sites associated with systolic and diastolic blood pressure and examined the temporal relationship between DNA methylation and blood pressure. The findings suggest the significance of DNA methylation in the development of hypertension.
Article
Geriatrics & Gerontology
Hanzhang Wu, Yeqing Gu, Ge Meng, Hongmei Wu, Shunming Zhang, Xuena Wang, Juanjuan Zhang, Tao Huang, Kaijun Niu
Summary: A study found that consuming plant-based foods has a positive effect on preventing dementia and depression. However, not all plant-based foods are beneficial for these conditions. The study also found that consuming healthy plant-based foods is associated with a lower risk of dementia and depression, while consuming unhealthy plant-based foods is associated with a higher risk.
Article
Geriatrics & Gerontology
Yeqing Gu, Tingjing Zhang, Jinhan Wang, Yanqi Song, Ge Meng, Hongmei Wu, Shunming Zhang, Xuena Wang, Juanjuan Zhang, Xinran Lu, Qiang Liu, Tao Huang, Jian Yang, Kaijun Niu
Summary: This study examines whether higher muscle strength is associated with a lower risk of major depressive disorder (MDD), regardless of genetic risk, among middle-aged and older adults. The results show a significant association between higher muscle strength and lower MDD risk, regardless of genetic risk. Therefore, it is recommended that muscle strength improvement should be encouraged for all individuals, including those with a high genetic risk for MDD.
Article
Endocrinology & Metabolism
Zhenhuang Zhuang, Xue Dong, Jinzhu Jia, Zhonghua Liu, Tao Huang, Lu Qi
Summary: This study found that a healthy sleep pattern is associated with a lower risk of type 2 diabetes mellitus (T2DM). They constructed a metabolomic signature consisting of 153 metabolites, which was strongly correlated with sleep pattern and inversely associated with T2DM risk. Mendelian randomization analysis further indicated a causal relationship between the metabolomic signature and incident T2DM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Yimin Zhao, Yueying Li, Wenxiu Wang, Zimin Song, Zhenhuang Zhuang, Duo Li, Lu Qi, Tao Huang
Summary: This study aimed to investigate the long-term associations between low-carbohydrate diets (LCDs) and low-fat diets (LFDs) and mortality among middle-aged and older individuals. The results showed that higher scores of overall LCD and unhealthy LCD were associated with increased risks of total and cause-specific mortality, while a healthy LCD was associated with slightly lower total mortality. On the other hand, the highest score of a healthy LFD was associated with significantly lower total, cardiovascular, and cancer mortality. These findings highlight the importance of maintaining a healthy LFD with less saturated fat in preventing all-cause and cause-specific mortality among middle-aged and older individuals.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xu Gao, Tong Geng, Meijie Jiang, Ninghao Huang, Yinan Zheng, Daniel W. Belsky, Tao Huang
Summary: Theory suggests that advanced biological aging is a potential risk factor for incident depression/anxiety in midlife and older adults. It could serve as a target for risk assessment and intervention.
NATURE COMMUNICATIONS
(2023)
Article
Business
Jeri Brittin, Ozgur M. Araz, Adrian Ramirez-Nafarrate, Terry T. -K. Huang
Summary: Studying the impact of built-environment changes on human behavior and health is challenging. While the use of dynamic furniture in schools may have some impact on childhood obesity, it is not the sole solution.
IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT
(2023)
Article
Endocrinology & Metabolism
Yimin Zhao, Yueying Li, Zhenhuang Zhuang, Zimin Song, Jinzhu Jia, Tao Huang
Summary: This study found that consuming salt regularly, regardless of genetic susceptibility, may increase the risk of developing type 2 diabetes. Public health interventions aimed at reducing excessive salt consumption may help prevent the onset of type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Zimin Song, Wenxiu Wang, Yimin Zhao, Wendi Xiao, Jie Du, Zhonghua Liu, Tao Huang, Yida Tang
Summary: This study suggests that adiposity may have a causal role in the development of cardiopulmonary multimorbidity, and maintaining an ideal waist-hip ratio may be effective in preventing CP-MM.
Correction
Multidisciplinary Sciences
Xu Gao, Tong Geng, Meijie Jiang, Ninghao Huang, Yinan Zheng, Daniel W. Belsky, Tao Huang
NATURE COMMUNICATIONS
(2023)