C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function

Improved outcomes in patients with ST-elevation myocardial infarction during the last 20 years are related to implementation of evidence-based treatments: experiences from the SWEDEHEART registry 1995–2014

(2017) Karolina Szummer et al.   EUROPEAN HEART JOURNAL

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes

(2017) Atsushi Anzai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial

(2017) Darja Karpova et al.   Journal of Translational Medicine

In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature

(2017) Tamás Baranyai et al.   Journal of Translational Medicine

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

Inflammation as a Driver of Adverse Left Ventricular Remodeling After Acute Myocardial Infarction

(2016) Peter C. Westman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction

(2015) Wan-Tseng Hsu et al.   CELL TRANSPLANTATION

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice

(2015) Yunching Chen et al.   HEPATOLOGY

Regulatory T cells in cardiovascular diseases

(2015) Xiao Meng et al.   Nature Reviews Cardiology

Concise Review: CXCR4/CXCL12 Signaling in Immature Hematopoiesis-Lessons From Pharmacological and Genetic Models

(2015) Darja Karpova et al.   STEM CELLS

Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function

(2014) Amit Saxena et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reperfusion Strategies in Acute Coronary Syndromes

(2014) Akshay Bagai et al.   CIRCULATION RESEARCH

Foxp3 + CD4 + T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte/Macrophage Differentiation

(2014) Johannes Weirather et al.   CIRCULATION RESEARCH

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Experimental Myocardial Infarction Induces Altered Regulatory T Cell Hemostasis, and Adoptive Transfer Attenuates Subsequent Remodeling

(2014) Rinat Sharir et al.   PLoS One

National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries

(2013) Jersey Chen et al.   CIRCULATION

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

(2013) Maulik D. Majmudar et al.   CIRCULATION

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor

(2013) D Karpova et al.   LEUKEMIA

CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia/Reperfusion Injury via Endothelial Nitric Oxide Synthase–Dependent Mechanism

(2012) Kentaro Jujo et al.   CIRCULATION

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

(2012) Nir Yogev et al.   IMMUNITY

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

(2012) Florian Leuschner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myocardial Infarction Triggers Chronic Cardiac Autoimmunity in Type 1 Diabetes

(2012) R. V. S. R. K. Gottumukkala et al.   Science Translational Medicine

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

(2011) Ting-Ting Tang et al.   BASIC RESEARCH IN CARDIOLOGY

Significant mobilization of both conventional and regulatory T cells with AMD3100

(2011) L. S. Kean et al.   BLOOD

CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer

(2011) E. Righi et al.   CANCER RESEARCH

Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease

(2011) T. I. G. van der Spoel et al.   CARDIOVASCULAR RESEARCH

Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4

(2011) M P Rettig et al.   LEUKEMIA

CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells

(2010) Marcin Dobaczewski et al.   AMERICAN JOURNAL OF PATHOLOGY

CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction

(2010) K. Jujo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE