Article
Gastroenterology & Hepatology
Katsutoshi Kuriyama, Yuzo Kodama, Masahiro Shiokawa, Yoshihiro Nishikawa, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Nobuyuki Kakiuchi, Teruko Tomono, Tomoaki Matsumori, Atsushi Mima, Toshihiro Morita, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Ryoichiro Kageyama, Tsutomu Chiba, Hiroshi Seno
Summary: Notch/Hes1 signaling is essential for the postnatal maturation of exocrine tissue in pancreatic progenitor cells, partially through the formation of centroacinar cells.
JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Immunology
Anne Sofie Bruun-Sorensen, Sarannya Edamana, Frederic H. Login, Signe Borgquist, Lene N. Nejsum
Summary: Aquaporins, proteins that facilitate passive water transport across cellular membranes, are often overexpressed in various cancers, including pancreatic ductal adenocarcinoma. This overexpression of aquaporins, such as aquaporin-1, aquaporin-3, and aquaporin-5, has been linked to metastasis and poor survival in pancreatic cancer, suggesting their potential as diagnostic markers and therapeutic targets.
Review
Oncology
Xiaoyang Lan, Gabrielle Robin, Jessica Kasnik, Grace Wong, Omar Abdel-Rahman
Summary: Pancreatic ductal carcinomas (PDACs) are difficult to diagnose early and have a poor prognosis. Many PDAC patients suffer from nutritional deficiencies related to their cancer. Pancreatic enzyme insufficiency (PEI) is a common cause of malnutrition in PDAC. This paper reviews past studies on malnutrition in PDAC, focusing on PEI and its treatment, and highlights knowledge gaps among healthcare professionals regarding PEI.
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Review
Oncology
Ruben Bellotti, Cornelia Speth, Timon E. Adolph, Cornelia Lass-Florl, Maria Effenberger, Dietmar Oefner, Manuel Maglione
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality, with recent research focusing on the microbial community in the pancreas as a potential target for early diagnosis and treatment. Specific microbial signatures may serve as novel screening tools, and micro- and mycobiota may represent promising targets for PDAC therapy.
Review
Oncology
Eleonora Lai, Pina Ziranu, Dario Spanu, Marco Dubois, Andrea Pretta, Simona Tolu, Silvia Camera, Nicole Liscia, Stefano Mariani, Mara Persano, Marco Migliari, Clelia Donisi, Laura Demurtas, Valeria Pusceddu, Marco Puzzoni, Mario Scartozzi
Summary: Despite ongoing research, there is still insufficient data on BRCA1/2-mutant PDAC, and more understanding is needed on the specific landscape of PDAC with BRCA mutations.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Rama Krishna Nimmakayala, Frank Leon, Satyanarayana Rachagani, Sanchita Rauth, Palanisamy Nallasamy, Saravanakumar Marimuthu, Gautam K. Shailendra, Yashpal S. Chhonker, Seema Chugh, Ramakanth Chirravuri, Rohitesh Gupta, Kavita Mallya, Dipakkumar R. Prajapati, Subodh M. Lele, Thomas C. Caffrey, Jean L. Grem, Paul M. Grandgenett, Michael A. Hollingsworth, Daryl J. Murry, Surinder K. Batra, Moorthy P. Ponnusamy
Summary: The study identified distinct subtypes of cancer stem cells (CSCs) in pancreatic ductal adenocarcinoma (PDAC) with specific metabolic and stemness signatures, which play a crucial role in organ-specific metastasis. Liver metastasis exhibited drug-resistant CSC- and EMT-like phenotype with glyco-oxidative metabolism, while lung metastasis displayed ALDH+/CD133+ and MET-like phenotype with oxidative metabolism.
Article
Genetics & Heredity
Zeru Li, Cheng Qin, Bangbo Zhao, Yuanyang Wang, Tianyu Li, Yutong Zhao, Weibin Wang
Summary: The study identified a new intron retention gene in pancreatic ductal adenocarcinoma, which is regulated by the upstream splicer DHX38. The reduction of DHX38 expression leads to the retention of the fourth intron of RELL2, causing nonsense-mediated mRNA decay and inhibiting apoptosis of pancreatic cancer cells, ultimately promoting drug resistance. This research provides a potential therapeutic target for pancreatic ductal adenocarcinoma.
Article
Multidisciplinary Sciences
Yuanxin Tang, Sheng Zhang, Jiazi Li, Chunli Wu, Qing Fan
Summary: Pancreatic Ductal Adenocarcinoma (PDAC) is a deadly disease with increasing death rates and no effective treatment. The study suggests that ID1 is a critical determinant of PDAC development and progression, serving as a potential malignant biomarker for the disease.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Jian Yang, Ying Liu, Shi Liu
Summary: Of all pancreatic cancer cases, pancreatic ductal adenocarcinoma (PDAC) accounts for approximately 90% and is characterized by its high invasiveness and metastatic potential. Epithelial-mesenchymal transition (EMT) is a crucial process for cancer cell invasion and spread, and it is influenced by cellular behaviors and the tumor microenvironment. Autophagy, a target of cancer therapy, has been found to have a dual and contradictory role in EMT-mediated PDAC invasion.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Editorial Material
Biology
Jessica Castrillon Lal
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a low survival rate. Understanding the complexity of tumor architecture and identifying targetable cellular phenotypes are major challenges in PDAC. Recent research has found recurrent gene expression patterns in malignant and fibroblast cellular neighborhoods in PDAC tumors that are correlated with treatment outcomes.
COMMUNICATIONS BIOLOGY
(2022)
Review
Oncology
Kongyuan Wei, Thilo Hackert
Summary: Surgery is the main potential cure for pancreatic ductal adenocarcinoma, with advancements in surgical techniques and multimodal approaches. Despite low survival rates, combining surgery with adjuvant therapy can increase five-year survival to around 20%. However, pancreatic resection is complex and high-risk, with ongoing developments in minimally-invasive and robotic approaches.
Review
Oncology
Eric M. Anderson, Shant Thomassian, Jun Gong, Andrew Hendifar, Arsen Osipov
Summary: Pancreatic cancer, with its highly immunosuppressive tumor microenvironment and dense stroma, presents challenges for traditional treatment approaches. Emerging treatment strategies have the potential to significantly improve outcomes for pancreatic cancer patients.
Article
Gastroenterology & Hepatology
Nai-Ming Chen, Albrecht Neesse, Moritz Lino Dyck, Benjamin Steuber, Alexander O. Koenig, Clara Lubeseder-Martellato, Thore Winter, Teresa Forster, Hanibal Bohnenberger, Julia Kitz, Kirsten Reuter-Jessen, Heidi Griesmann, Jochen Gaedcke, Marian Grade, Jin-San Zhang, Wan-Chi Tsai, Jens Siveke, Hans-Ulrich Schildhaus, Philipp Stroebel, Steven A. Johnsen, Volker Ellenrieder, Elisabeth Hessmann
Correction
Chemistry, Multidisciplinary
Barbara Gruenwald, Jennifer Vandooren, Erica Locatelli, Pierre Fiten, Ghislain Opdenakker, Paul Proost, Achim Krueger, Jean Paul Lellouche, Liron Limor Israel, Louis Shenkman, Mauro Comes Franchini
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Medicine, General & Internal
Clara Lubeseder-Martellato, Katharina Alexandrow, Ana Hidalgo-Sastre, Irina Heid, Sophie Luise Boos, Thomas Briel, Roland M. Schmid, Jens T. Siveke
Review
Cell Biology
Barbara Grunwald, Benjamin Schoeps, Achim Krueger
TRENDS IN CELL BIOLOGY
(2019)
Article
Oncology
Joan M. Romero, Barbara Grunwald, Gun-Ho Jang, Prashant P. Bavi, Aaditeya Jhaveri, Mehdi Masoomian, Sandra E. Fischer, Amy Zhang, Robert E. Denroche, Ilinca M. Lungu, Angela De Luca, John M. S. Bartlett, Jing Xu, Niandong Li, Sharon Dhaliwal, Sheng-Ben Liang, Dianne Chadwick, Foram Vyas, Peter Bronsert, Rama Khokha, Tracy L. McGaha, Faiyaz Notta, Pamela S. Ohashi, Susan J. Done, Grainne M. O'Kane, Julie M. Wilson, Jennifer J. Knox, Ashton Connor, Yifan Wang, George Zogopoulos, Steven Gallinger
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Grainne M. O'Kane, Barbara T. Grunwald, Gun-Ho Jang, Mehdi Masoomian, Sarah Picardo, Robert C. Grant, Robert E. Denroche, Amy Zhang, Yifan Wang, Bernard Lam, Paul M. Krzyzanowski, Illinca M. Lungu, John M. S. Bartlett, Melanie Peralta, Foram Vyas, Rama Khokha, James Biagi, Dianne Chadwick, Stephanie Ramotar, Shawn Hutchinson, Anna Dodd, Julie M. Wilson, Faiyaz Notta, George Zogopoulos, Steven Gallinger, Jennifer J. Knox, Sandra E. Fischer
CLINICAL CANCER RESEARCH
(2020)
Article
Multidisciplinary Sciences
Ana Hidalgo-Sastre, Clara Lubeseder-Martellato, Thomas Engleitner, Katja Steiger, Suyang Zhong, Judit Desztics, Rupert Oellinger, Roland Rad, Roland M. Schmid, Heiko Hermeking, Jens T. Siveke, Guido von Figura
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Ana Hidalgo-Sastre, Judit Desztics, Zahra Dantes, Katharina Schulte, Hilal Kabadayi Ensarioglu, Blessing Bassey-Archibong, Rupert Oellinger, Thomas Engleiter, Lyndsay Rayner, Henrik Einwaechter, Juliet M. Daniel, Ali Sameer Abdulghani Altaee, Katia Steiger, Marina Lesina, Roland Rad, Maximilian Reichert, Guido von Figura, Jens T. Siveke, Roland Schmid, Clara Lubeseder-Martellato
Article
Medicine, Research & Experimental
Zahra Dantes, Hsi-Yu Yen, Nicole Pfarr, Christof Winter, Katja Steiger, Alexander Muckenhuber, Alexander Hennig, Sebastian Lange, Thomas Engleitner, Rupert Oellinger, Roman Maresch, Felix Orben, Irina Heid, Georgios Kaissis, Kuangyu Shi, Geoffrey Topping, Fabian Stoegbauer, Matthias Wirth, Katja Peschke, Aristeidis Papargyriou, Massoud Rezaee-Oghazi, Karin Feldmann, Arlett P. G. Schaefer, Raphela Ranjan, Clara Lubeseder-Martellato, Daniel E. Stange, Thilo Welsch, Marc Martignoni, Gueralp O. Ceyhan, Helmut Friess, Alexander Herner, Lucia Liotta, Matthias Treiber, Guido von Figura, Mohamed Abdelhafez, Peter Klare, Christoph Schlag, Hana Alguel, Jens Siveke, Rickmer Braren, Gregor Weirich, Wilko Weichert, Dieter Saur, Roland Rad, Roland M. Schmid, Guenter Schneider, Maximilian Reichert
Article
Oncology
Vishnu Mohan, Jean P. Gaffney, Inna Solomonov, Maxim Levin, Mordehay Klepfish, Sophia Akbareian, Barbara Grunwald, Orly Dym, Miriam Eisenstein, Kenneth H. Yu, David P. Kelsen, Achim Kruger, Dylan R. Edwards, Irit Sagi
Summary: The study successfully developed a monoclonal antibody GSM-192 targeting matrix metalloproteinase 7, which induced pancreatic cancer cell apoptosis, reduced migration, and increased sensitivity to chemotherapy.
Article
Immunology
Chris D. Hermann, Benjamin Schoeps, Celina Eckfeld, Enkhtsetseg Munkhbaatar, Lukas Kniep, Olga Prokopchuk, Nils Wirges, Katja Steiger, Daniel Haeussler, Percy Knolle, Emily Poulton, Rama Khokha, Barbara T. Gruenwald, Ihsan Ekin Demir, Achim Krueger
Summary: This study uncovers a sex disparity in liver metastasis independent of lifestyle, with TIMP1 playing a role in promoting liver metastasis in male pancreatic cancer patients and mice. Identifying subpopulations with increased TIMP1 levels may have implications for precision medicine.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Barbara T. Grunwald, Antoine Devisme, Geoffroy Andrieux, Foram Vyas, Kazeera Aliar, Curtis W. McCloskey, Andrew Macklin, Gun Ho Jang, Robert Denroche, Joan Miguel Romero, Prashant Bavi, Peter Bronsert, Faiyaz Notta, Grainne O'Kane, Julie Wilson, Jennifer Knox, Laura Tamblyn, Molly Udaskin, Nikolina Radulovich, Sandra E. Fischer, Melanie Boerries, Steven Gallinger, Thomas Kislinger, Rama Khokha
Summary: Through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models, we identified distinct subTMEs in the human pancreatic tumor microenvironment (TME) that are linked to tumor immunity, subtypes, differentiation, and treatment response. Reactive subTMEs rich in coordinated fibroblast communities were immune hot, while matrix-rich deserted subTMEs harbored fewer activated fibroblasts but showed chemoprotective features. These subTMEs originated in fibroblast differentiation trajectories and produced patient-specific heterogeneity tightly linked to malignant biology.
Article
Oncology
Bryn Golesworthy, Yifan Wang, Amanda Tanti, Alain Pacis, Joan Miguel Romero, Adeline Cuggia, Celine Domecq, Guillaume Bourdel, Robert E. Denroche, Gun Ho Jang, Robert C. Grant, Ayelet Borgida, Barbara T. Grunwald, Anna Dodd, Julie M. Wilson, Guillaume Bourque, Grainne M. O'Kane, Sandra E. Fischer, Chelsea Maedler Kron, Pierre-Olivier Fiset, Atilla Omeroglu, William D. Foulkes, Steven Gallinger, Marie-Christine Guiot, Zu-Hua Gao, George Zogopoulos
Summary: This study investigated the immune contexture of HR-d PDAC using multiplex immunohistochemistry. The results showed higher infiltration of intra-tumoral CD8+ T-cells and increased FOXP3+ Tregs in HR-d PDAC compared to HR/MMR-intact PDAC. Additionally, PD-L1 positivity was observed in a subset of HR-d PDAC cases. These findings suggest that HR-d PDAC may be responsive to immune checkpoint inhibitor treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Jose L. Cadavid, Simon Latour, Ferris Nowlan, Ileana L. Co, Natalie Landon-Brace, Bradly G. Wouters, Barbara T. Grunwald, Mark Nitz, Hartland Warren Jackson, Alison P. McGuigan
Summary: The spatial configuration of cells in the tumor microenvironment affects cancer and fibroblast cell phenotypes, leading to the clinical challenges of tumor heterogeneity and therapeutic resistance. In this study, a versatile system using pancreatic ductal adenocarcinoma as a model is described to investigate the impact of tissue architecture on cell phenotype. High dimensional characterization using CyTOF reveals distinct hypoxia and proliferation gradients in tissue architecture, and phenotypic markers for both cell types are also graded in a way that cannot be explained by hypoxia or coculture alone.
ADVANCED HEALTHCARE MATERIALS
(2023)
Letter
Oncology
Sheron Perera, Gun Ho Jang, Robert Grant, Faiyaz Notta, Barbara Grunwald, Steven Gallinger, Jennifer J. Knox, Grainne M. O'Kane
CLINICAL CANCER RESEARCH
(2023)