期刊
CHEMMEDCHEM
卷 14, 期 7, 页码 779-787出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201800756
关键词
antitumor agents; bile acids; dihydroartemisinin; hepatocellular carcinoma; natural products
资金
- Ministry of Science and Technology in Taiwan [MOST 105-2320-B-002-020-MY3]
- National Taiwan University
- University of Ferrara (fondi FAR)
A series of hybrid compounds based on natural products-bile acids and dihydroartemisinin-were prepared by different synthetic methodologies and investigated for their in vitro biological activity against HL-60 leukemia and HepG2 hepatocellular carcinoma cell lines. Most of these hybrids presented significantly improved antiproliferative activities with respect to dihydroartemisinin and the parent bile acid. The two most potent hybrids of the series exhibited a 10.5- and 15.4-fold increase in cytotoxic activity respect to dihydroartemisinin alone in HL-60 and HepG2 cells, respectively. Strong evidence that an ursodeoxycholic acid hybrid induced apoptosis was obtained by flow cytometric analysis and western blot analysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据