Article
Biochemistry & Molecular Biology
Teekaraman Dhanaraj, Manju Mohan, Jagadeesan Arunakaran
Summary: Research has shown that quercetin inhibits the survival and proliferation of human metastatic ovarian cancer cells by inactivating PI3K/Akt, Ras/Raf pathways, and EGFR expression. It also alters N-cadherin expression, decreases gelatinase secretion and MMP-2/-9 gene expression, and inhibits migration and adhesion of the cancer cells. These findings suggest that quercetin could be a valuable therapeutic drug for the treatment and prevention of metastatic ovarian cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Medicine, Research & Experimental
Vaikundamoorthy Ramalingam, Pavithra Muthukumar Sathya, Thimmarayan Srivalli, Harshavardhan Mohan
Summary: In this study, wurtzite type zinc oxide nanoparticles functionalized with quercetin were synthesized and shown to have excellent activity in treating ovarian cancer.
Article
Biology
Chunqiu Xiong, Bingbing Yan, Suhua Xia, Fei Yu, Jingjing Zhao, Hua Bai
Summary: This study demonstrated the anticancer effects of Tilianin in PA-1 cells through its ability to significantly decrease cell viability and induce apoptosis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Weihan Yang, Runfeng Liu, Qinqiang Sun, Xingchen Huang, Junjun Zhang, Liangfeng Huang, Pengfei Zhang, Ming Zhang, Qiang Fu
Summary: This study found that quercetin could attenuate the effects of endoplasmic reticulum stress on granulosa cells by the PERK/CHOP signaling pathway, providing a novel strategy for inhibiting the apoptosis of granulosa cells.
Article
Integrative & Complementary Medicine
Hyo In Kim, Sol Ji Lee, Yu-Jeong Choi, Min Jeong Kim, Tai Young Kim, Seong-Gyu Ko
Summary: This study found that quercetin can induce apoptosis in GBM cells by inhibiting the Axl/IL-6/STAT3 signaling pathway, suggesting its potential as an anticancer agent.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Dejun Xu, Xiaohan Jiang, Yukun Wang, Shuaifei Song
Summary: LRH-1 is highly expressed in bovine granulosa cells of atretic follicles. It induces apoptosis of the cells through downregulating the progestogen receptor signaling pathway, thus modulating bovine follicular atresia.
Article
Chemistry, Physical
Sahar Qazi, Kushagra Khanna, Khalid Raza
Summary: This article acknowledges the support of the DST-INSPIRE fellowship provided by the Department of Science & Technology, Govt. of India, and expresses gratitude to Dr. Ashok Sharma from the Department of Biochemistry, All India Institute of Medical Sciences, New Delhi-110029, for providing scientific insights about the target POTEE worked in this research study.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E. Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A. Hannun, Takeshi Nabe, Kazuyuki Kitatani
Summary: Regulation of sphingolipid metabolism has a significant impact on cellular homeostasis and cancer progression. Dysregulation of ceramide-centered metabolism is associated with metastatic potential in ovarian cancer cells. Specifically, the CerS2-C-24:1-ceramide axis, possibly counteracted by neutral ceramidase, plays a key role in limiting cell motility and metastatic potential.
Article
Environmental Sciences
Lulu Niu, Wenwen Li, Xin Chen, Xiaosan Su, Jingjing Dong, Quanyang Liao, Xuhong Zhou, Shaoqing Shi, Ruifen Sun
Summary: The active constituent 1-Monopalmitin (1-Mono) in Mougeotia nummuloides and Spirulina major inhibits the proliferation of lung cancer cells and induces apoptosis through the PI3K/Akt pathway. It also suppresses autophagy, and combining with autophagy inhibitor Chloroquine enhances its cytotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Mahasin Abdel Rhman, Nikita Devnarain, Rene Khan, Peter M. O. Owira
Summary: This study reveals that the combination of quercetin and naringenin in citrus fruits and vegetables can synergistically induce oxidative stress and apoptosis, and reduce cell proliferation in breast cancer cells.
Article
Multidisciplinary Sciences
Ozlem Calbay, Ravi Padia, Mahmuda Akter, Lei Sun, Bin Li, Nicole Qian, Jianhui Guo, Zheng Fu, Lingtao Jin, Shuang Huang
Summary: This study reveals a novel mechanism of cell death, caspase-1-dependent pyroptosis, that does not require the participation of ASC/inflammasome.
Review
Oncology
Daniel Westaby, Juan M. Jimenez-Vacas, Ana Padilha, Andreas Varkaris, Steven P. Balk, Johann S. de Bono, Adam Sharp
Summary: This article discusses the treatment of prostate cancer and the need for new options. Triggering apoptosis in cancer cells is an attractive strategy, and BH3 mimetics have been designed for this purpose. The article provides an overview of cell death and apoptosis, focusing on the intrinsic pathway, and discusses the potential use of BH3 mimetics in treating prostate cancer.
Article
Reproductive Biology
Xiameng Shen, Conghui Wang, Huihui Zhu, Yaping Wang, Xinyu Wang, Xiaodong Cheng, Wanzhong Ge, Weiguo Lu
Summary: Tumor-derived exosomes play important roles in promoting migration and invasion of ovarian cancer cells. CD44, transferred through exosomes, influences the metastatic phenotype of cancer cells and may be a potential therapeutic target for ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Jing Zhang, Xinyan Xu, Yongfeng Chen, Xiaoju Guan, Hong Zhu, Yuhong Qi
Summary: In this study, the regulatory effect of the CRM1-Survivin axis on the progression of ovarian cancer was explored. The results showed that CRM1 silencing inhibited the proliferation and colony formation of ovarian cancer cells and promoted cell apoptosis by promoting Caspase-3 activation. Survivin was positively regulated by CRM1 and promoted the development of ovarian cancer. This suggests that the CRM1-Survivin axis may serve as a potential therapeutic target for ovarian cancer.
Article
Medicine, Research & Experimental
Somayeh Hashemi Sheikhshabani, Zeinab Amini-Farsani, Shima Rahmati, Ali Jazaeri, Marzieh Mohammadi-Samani, Samira Asgharzade
Summary: The study revealed that oleuropein regulated the expression of miRNAs in ovarian cancer cells, potentially resulting in apoptosis induction, cell proliferation inhibition, and decline in cisplatin resistance. Further experiments in animal models of ovarian cancer are suggested to confirm the findings.
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)