Article
Biochemistry & Molecular Biology
Yi Gong, Haoyi Li, Fei Wu, Yishuai Li, Shicui Zhang
Summary: Derived from AP-2 complex subunit mu-A, the short peptide AP10W exhibits notable antifungal activities against Candida albicans and Aspergillus fumigatus. It inhibits fungal biofilm formation and reduces pre-established fungal biofilms. AP10W acts through various mechanisms including interaction with fungal cell walls, enhancement of cell wall permeability, membrane depolarization induction, and increase in intracellular ROS generation. It shows low toxicity towards mammalian cells and promotes wound healing in C. albicans-infected skin.
Article
Chemistry, Medicinal
Simon D. P. Baugh, Anna Chaly, Damian G. Weaver, Jeffrey C. Pelletier, Sandeep Thanna, Katie B. Freeman, Allen B. Reitz, Richard W. Scott
Summary: The research team has developed a series of non-peptide antifungal analogs through chemical optimization, resulting in highly potent, broad-spectrum compounds with low mammalian cell cytotoxicity. These compounds have the potential to become new antifungal agents.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Abeer Abdulkhalek Ghoniem, Kamar M. Abd El-Hai, Ayman Y. El-khateeb, Noha M. Eldadamony, Samy F. Mahmoud, Ashraf Elsayed
Summary: The study investigated the inhibitory effects of T. harzianum and chamomile flower extract against Pythium ultimum, showing a significant reduction in radial growth and disease incidence of bean pathogen. The combination of the two also led to increased plant growth and enzyme activities.
Article
Biochemistry & Molecular Biology
Ruifang Li, Jiasha Wu, Fuyang He, Qingpeng Xu, Kedong Yin, Shang Li, Weitong Li, Ao Wei, Lan Zhang, Xin-Hui Zhang, Beibei Zhang
Summary: Researchers designed a set of CGA-N12 analogues that showed stronger antifungal activity compared to the original compound CGA-N12. These analogues were able to kill invasive Candida species and their persist cells, as well as inhibit biofilm formation and eradicate preformed biofilms.
BIOORGANIC CHEMISTRY
(2023)
Article
Microbiology
Lynn Miesel, Melanie T. Cushion, Alan Ashbaugh, Santiago R. Lopez, Voon Ong
Summary: Rezafungin, a novel echinocandin, has shown efficacy against Candida, Aspergillus, and Pneumocystis in prophylactic studies. By reducing fungal burden and preventing infection, it has the potential to be a single-agent prophylaxis against invasive fungal diseases caused by these pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Anna Dahlman, Manoj Puthia, Jitka Petrlova, Artur Schmidtchen, Ganna Petruk
Summary: TCP-25, an antimicrobial peptide with antibacterial and immunomodulatory effects, demonstrates the ability to inhibit Candida growth and reduce associated inflammation. Both in vitro and in vivo experiments validate the therapeutic potential of TCP-25 against Candida infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Zhi Li, Fangwang Shen, Lili Song, Shicui Zhang
Summary: NP20 is a novel antifungal peptide that has the ability to kill spores of Aspergillus niger and Aspergillus fumigatus and directly damage their surface, membrane, cytoplasm, organelle, and nucleus. It is active under temperature stress and a wide range of pH. The mechanisms underlying NP20's antifungal activity include binding with and passing through the fungal cell wall, interfering with the lipid membrane, inducing intracellular ROS production, DNA fragmentation, and protein synthesis inhibition of the fungal cells.
MARINE BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abirami Raja, Govind Pratap Singh, Sana A. Fadil, Sameh S. Elhady, Fadia S. Youssef, Mohamed L. Ashour
Summary: This study evaluated the anti-osteoporotic activity of Matricaria chamomilla L. flower ethanol extract in a rat model of steroid-induced osteoporosis for the first time. The extract showed reductions in serum calcium and phosphate levels and an increase in serum magnesium level, as well as a decrease in creatinine and alkaline phosphatase levels. Biomechanical and histopathological analyses supported the beneficial effects of the extract on bone strength and structure. The major phenolic compound rutin exhibited potential inhibitory effects on cathepsin K. The findings suggest that this plant extract has therapeutic potential for osteoporosis.
Article
Microbiology
Cecilia G. Carvalhaes, Abby L. Klauer, Paul R. Rhomberg, Michael A. Pfaller, Mariana Castanheira
Summary: Rezafungin is a new echinocandin with potent activity against candidemia and invasive candidiasis. It also shows activity against Aspergillus isolates. The new CLSI breakpoints are important for understanding the susceptibility of Candida spp. and rezafungin.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Aviran Amir, Michal Levin-Khalifa, Tamar Dvash
Summary: Fungal infections are becoming more of a problem for immunocompromised individuals, and there is evidence of new medicine-resistant strains. Researchers have discovered an ethanol amide derivative of Nystatin that shows promise as a potential drug with higher solubility and lower toxicity.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Microbiology
Guillermo Garcia-Effron
Summary: Antifungal susceptibility testing has become a mandatory aspect of clinical practice, although the direction of mycological diagnosis is shifting towards non-culture-based methods. As a result, there is a growing reliance on empirical antifungal treatment due to limitations in studying the sensitivity of infectious strains. One explored solution involves combining non-culture diagnostics with molecular detection to identify resistant organisms and resistance mechanisms.
Article
Biochemistry & Molecular Biology
Ahmed Qasem, Hamza Assaggaf, Domenico Montesano, Zineb Khalil, Samiah Hamad Al-Mijalli, Aicha El Baaboua, Nasreddine El Omari, Naoual El Menyiy, Saad Bakrim, Ryan A. Sheikh, Mohammed Merae Alshahrani, Ahmed Abdullah Al Awadh, Gokhan Zengin, Abdelhakim Bouyahya, Hanae Naceiri Mrabti
Summary: This exploratory investigation aimed to determine the chemical composition and evaluate the biological properties of Matricaria chamomilla L. essential oils. The results showed that the essential oils exhibited antioxidant, antimicrobial, and antidiabetic activities. Further research on the bioactive compounds is necessary.
Article
Food Science & Technology
Brisha Arulrajah, Mohammed S. Qoms, Belal J. Muhialdin, Hanan Hasan, Mohammad Zarei, Anis Shobirin Meor Hussin, De-Ming Chau, Nazamid Saari
Summary: This study developed natural antibacterial and antifungal peptides from kenaf seed powder, which showed strong antimicrobial activity against bacteria and fungi. The peptides exhibited bactericidal and fungicidal effects in a short period of time and remained active under different conditions. Application of these peptides in fruit juices and bread extended their shelf-life significantly.
Article
Immunology
Aiah Mustafa Khateb, Shatha Ali Alkhaibari
Summary: This cross-sectional study evaluated the current status of fungal diagnostics in Saudi Arabia and found that the incidence of fungal infections has increased significantly. Most hospitals still rely on traditional methods of fungal culture and microscopic examination, with limited use of antifungal susceptibility testing and molecular methods. Improvement in diagnostic equipment and training are needed to enhance fungal diagnosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Physical
Mateusz Jamrozy, Magdalena Glab, Sonia Kudlacik-Kramarczyk, Anna Drabczyk, Pawel Gajda, Bozena Tyliszczak
Summary: In this study, acrylic hydrogels were modified with Matricaria chamomilla L. extract. By using different modifiers and photoinitiators, hydrogels with varying physicochemical properties were obtained, which could positively affect their application potential.
Article
Chemistry, Inorganic & Nuclear
Mohammadhassan Gholami-Shabani, Fattah Sotoodehnejadnematalahi, Masoomeh Shams-Ghahfarokhi, Ali Eslamifar, Mehdi Razzaghi-Abyaneh
Summary: In this study, functional platinum nanoparticles were synthesized using the cell-free filtrate of Penicillium pinophilum. The synthesized nanoparticles showed antimicrobial activity and strong cytotoxic effects against cancer cells.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Health Care Sciences & Services
Fatemeh Keshmiri, Yaser Ghelmani
Summary: This study aimed to assess the impact of continuing interprofessional education on collaborative self-efficacy, attitude toward the team, and interprofessional learning. The results revealed significant improvements in participants' attitude toward the team, attitude toward interprofessional learning, and interprofessional collaborative self-efficacy.
JOURNAL OF INTERPROFESSIONAL CARE
(2023)
Review
Biochemistry & Molecular Biology
Samaneh Sepahi, Sina Gerayli, Mohammad Delirrad, Mohammad Ehsan Taghavizadeh Yazdi, Hadi Zare-Zardini, Behzad Bushehri, Adel Ghorani-Azam
Summary: Inhibition of cholinesterase (ChE) activity has been used as the main diagnostic method for organophosphate (OP) and carbamate pesticides poisoning. However, ChE activity may also be altered due to exposure to other toxicants and medical conditions. This systematic review identified additional biomarkers, such as beta-glucuronidase, neuropathy target esterase, and hematological indicators, that show high sensitivity and accuracy in the diagnosis of OP poisoning.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Immunology
Arezoo Fallah, Hamid Sedighian, Elham Behzadi, Seyed Asghar Havaei, Reza Kachuei, Abbas Ali Imani Fooladi
Summary: The emergence of Covid-19 is a global problem causing increasing mortality rates and lacking verified treatment. The abnormal unrestricted response called cytokine storm, which is triggered by increased amounts of cytokine production, contributes to the severity of Covid-19 and the development of respiratory failure and pneumonia. The interaction between SARS-CoV-2 and endotoxins plays a role in the excessively elevated release of cytokines and the worsening of Covid-19.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Mehdi Goudarzi, Simasadat Seyedjavadi, Parmida Bagheri, Masoud Dadashi, Mohammad Javad Nasiri
Summary: This descriptive cross-sectional study provides insights into the molecular characteristics and antimicrobial resistance of fusidic acid resistant Staphylococcus aureus strains isolated from hospitalized patients in Iran. The prevalence of fusidic acid resistance in S. aureus isolates was found to be 15.1%, with fusB being the most predominant acquired gene. The study highlights the importance of understanding the local prevalence of FA-resistant MRSA for effective treatment, control, and reduction of these isolates.
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2023)
Review
Microbiology
Parvindokht Fazel, Hamid Sedighian, Elham Behzadi, Reza Kachuei, Abbas Ali Imani Fooladi
Summary: Bacterial co-infections and secondary bacterial infections are critical risk factors for the severity and mortality rates of COVID-19, and further studies are needed to understand their causes and prevalence.
CURRENT MICROBIOLOGY
(2023)
Review
Infectious Diseases
Fatemeh Sodeifian, Moein Zangiabadian, Erfan Arabpour, Naghmeh Kian, Fartous Yazarlou, Mehdi Goudarzi, Rosella Centis, Zahra Sadat Seghatoleslami, Mahdis Chahar Kameh, Bardia Danaei, Hossein Goudarzi, Mohammad Javad Nasiri, Giovanni Sotgiu, Giovanni Battista Migliori
Summary: This systematic review and meta-analysis aimed to explore the safety and efficacy of tigecycline for the treatment of multi drug-resistant Acinetobacter baumannii. The results showed that tigecycline had similar efficacy compared to other antibiotics, but it had a higher mortality rate and lower microbiological eradication rate. Therefore, the use of tigecycline for the treatment of multi drug-resistant A. baumannii is not recommended.
MICROBIAL DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Chakameh Amini, Maryam Fazeli, Mohammad Javad Nasiri, Sara Bahonar, Masoud Dadashi, Mehrdad Haghighi, Mirmohammad Miri, Mehdi Goudarzi
Summary: This study investigated the genetic characteristics of PVL-positive S. aureus strains isolated from clinical samples. The emergence of vancomycin-resistant S. aureus strains among PVL-positive S. aureus strains in Iran is a serious alarm and poses the greatest concern in the treatment of staphylococcal infections in the healthcare setting. Direct transfers between community and nosocomial PVL-positive S. aureus types were observed.
ARCHIVES OF CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Zahra Rahmani, Sareh Sadat Hosseini, Parmida Bagheri, Mehdi Goudarzi
Summary: The study investigated the antibiotic resistance profile and genetic variability of Staphylococcus aureus isolates from ear infections in adult patients in Tehran, Iran. The results showed high resistance to antibiotics and strong biofilm formation ability in these strains. Different genetic differences were observed in strains from different types of ear infections.
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2023)
Review
Public, Environmental & Occupational Health
Farzaneh Fesahat, Amir Masoud Firouzabadi, Hadi Zare-Zardini, Maryam Imani
Summary: Human beta-defensins (hBDs) are cationic peptides with amphipathic spatial shape and high cysteine content. The members of this peptide family have various functions in the human body, including the reproductive system. Beta-defensin 1 interacts with chemokine receptor 6 (CCR6) to prevent bacterial infections in the male reproductive system and has positive effects on antitumor immunity and fertilization in the female reproductive system. Beta-defensin 2 has antibacterial action and may play a role in preventing cervical cancer through interactions with dendritic cells. Beta-defensin 126 is essential for sperm motility and protection against immune system factors. This study reviews the roles of beta-defensin 1, beta-defensin 2, and beta-defensin 126 in both the male and female reproductive systems.
AMERICAN JOURNAL OF MENS HEALTH
(2023)
Review
Cell & Tissue Engineering
Mehrdad Moosazadeh Moghaddam, Parvindokht Fazel, Arezoo Fallah, Hamid Sedighian, Reza Kachuei, Elham Behzadi, Abbas Ali Imani Fooladi
Summary: Microbial diseases pose a major threat to global health, resulting in significant mortality and economic losses annually. Traditional medications directly target pathogens but excessive use can lead to drug resistance and worsen infectious diseases. New therapeutic methods, such as MSC-Exos and AMPs, offer different strategies to combat pathogens and show potential in treating microbial infectious diseases, particularly pulmonary infections and sepsis.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Medicine, General & Internal
Abbasali Mokarmat-Yazdi, Masoumeh Mazidi, Mohsen Ghiasi Tarzi, Hadi Zare-Zardini
Summary: The study collected the germ of Date seeds by breaking a thousand date kernels, and it was powdered and dissolved in distilled water to achieve different concentrations. Cancerous and normal cell lines were treated with these concentrations for different time periods, and cell viability and P53 gene expression were evaluated. Results showed that the germ of Date seed led to a decrease in viable cells and an increase in P53 gene expression in both cancerous and normal cell lines.
Article
Medicine, General & Internal
Shervin Dokht Farhangfar, Farzaneh Fesahat, Hadi Zare-Zardini, Mahdi Dehghan-Manshadi, Fateme Zare, Seyed Mohsen Miresmaeili, Maryam Vajihinejad, Hossein Soltaninejad, Adel Ghorani-Azam
Summary: The study evaluated the efficacy of Ginsenoside Rh2 and its combination with arginine-reduced graphene (Gr-Arg-Rh2) in treating mice with breast cancer. The results showed that mice treated with Gr-Arg and Gr-Arg-Rh2 exhibited more energy compared to Rh2 and control groups. Based on these findings, Gr-Arg-Rh2 may reduce cancer-related fatigue and low energy in cancer patients.
Article
Medicine, General & Internal
Yaser Ghelmani, Mohammad Hossein Ahrar Yazdi, Farimah Shamsi, Tahereh Fallah
Summary: This study evaluated lung CT images in COVID-19 patients and analyzed their relationship with clinical and laboratory factors as well as the worst disease condition. The results showed a high prevalence of lung and cardiac involvement. Age was significantly related to recovery. CT score, bilateral lung involvement, and Crazy paving had a significant effect on recovery rate.
Article
Medicine, General & Internal
Nooshin Hatamizadeh, Afsar Sadat Tabatabaei Bafghi, Fahimeh Nokhostin, Shokoufeh Behdad, Farimah Shamsi
Summary: The aim of this study was to compare the effectiveness of rectal and sublingual misoprostol administration in reducing bleeding during and after cesarean section. The results showed no significant difference between the two groups in intraoperative and postoperative bleeding, as well as side effects. Therefore, sublingual misoprostol can be used as an alternative to rectal misoprostol in preventing postpartum hemorrhage.
Article
Biochemistry & Molecular Biology
Ali Mehri, Karim Mahnam, Hajar Sirous, Mahmoud Aghaei, Leila Rafiei, Mahboubeh Rostami
Summary: One potential approach for tumor therapy is inhibiting the binding between MDM2 and p53 to reactivate p53 in tumor cells. In this study, Monastrol derivatives were designed as MDM2 inhibitors and evaluated for their cytotoxicity on cancer cells. Compound 5d showed the best inhibitory results in silico and in vitro experiments. These findings suggest that Monastrol derivatives have the potential to be candidates for MDM2 inhibition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2024)