Article
Immunology
Tiffany Carr, Stephanie McGregor, Sheila Dias, Mihalis Verykokakis, Michelle M. Le Beau, Hai-Hui Xue, Mikael Sigvardsson, Elizabeth T. Bartom, Barbara L. Kee
Summary: T lymphocyte acute lymphoblastic leukemia (T-ALL) is a heterogeneous disease affecting T cells at multiple stages of their development. The timing of mutation in the transcription factor LEF1 impacts its function as a tumor suppressor or oncogene in T-ALL. Leukemic cells become addicted to the presence of LEF1, and deletion prior to transformation accelerates leukemogenesis and alters gene expression controlling receptor-signaling pathways. Mouse models are useful for understanding the cooperation and consequence of mutational order in leukemogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Vivekananda Budamagunta, Thomas C. Foster, Daohong Zhou
Summary: Immunosenescence is a complex phenomenon that leads to age-related immune dysfunction, resulting in various pathologies such as decreased ability to clear senescent and cancerous cells, increased autoimmune response, reduced ability to combat pathogens, and diminished response to vaccination. Cellular senescence and immunosenescence have not been extensively explored in terms of their relationship, yet in the context of the ongoing pandemic, immunosenescence has become a topic of great importance.
Review
Immunology
Angela Boahen, Dailun Hu, Murray J. Adams, Philip K. Nicholls, Wayne K. Greene, Bin Ma
Summary: This review explores the connections between the central nervous system (CNS) and the peripheral nervous system (PNS) with the immune system, focusing on the impact of these interactions on health and disease. Understanding these neuroimmune interactions could lead to new therapeutic approaches for neurological, neuroimmunological, infectious, inflammatory, and immunological disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Chenqu Suo, Emma Dann, Issac Goh, Laura Jardine, Vitalii Kleshchevnikov, Jong-Eun Park, Rachel A. Botting, Emily Stephenson, Justin Engelbert, Zewen Kelvin Tuong, Krzysztof Polanski, Nadav Yayon, Chuan Xu, Ondrej Suchanek, Rasa Elmentaite, Cecilia Dominguez Conde, Peng He, Sophie Pritchard, Mohi Miah, Corina Moldovan, Alexander S. Steemers, Pavel Mazin, Martin Prete, Dave Horsfall, John C. Marioni, Menna R. Clatworthy, Muzlifah Haniffa, Sarah A. Teichmann
Summary: This study used single-cell genomics to decode the development of the human immune system during prenatal stages, revealing new cell types and the timing of immune function acquisition. The findings have important implications for cell engineering, regenerative medicine, and disease understanding.
Article
Immunology
Ho-Sup Lee, Hao Sun, Frederic Lagarrigue, Sarah Hyun Ji Kim, Jay W. Fox, Nicholas E. Sherman, Alexandre R. Gingras, Mark H. Ginsberg
Summary: The study reveals that Phostensin (Ptsn) is a component of the Mig-10/RIAM/Lamellipodin (MRL protein)-integrin-talin (MIT) complex and plays a role in stabilizing the complex by dephosphorylating Rap1. This stabilization enhances lymphocyte integrin-mediated functions and loss of Ptsn ameliorates T cell-mediated colitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Alessandro Marins-Dos-Santos, Jackline de Paula Ayres-Silva, Dina Antunes, Carlos Jose de Carvalho Moreira, Marcelo Pelajo-Machado, David Alfaro, Agustin G. Zapata, Adriana Cesar Bonomo, Wilson Savino, Juliana de Meis, Desio Aurelio Farias-de-Oliveira
Summary: This study demonstrates that Trypanosoma cruzi causes high tissue parasitism during the acute phase of Chagas disease. In mice with acute oral infection, the bone marrow cells are highly parasitized, particularly in the perivascular, intravascular, and near bone regions. The infection leads to a decrease in hematopoietic cells in the bone marrow, except for an increase in hematopoietic stem and progenitor cells. The study also suggests that the spleen may play a role in emergency hematopoiesis during acute T. cruzi infection. Overall, this research provides important insights into the impact of T. cruzi infection on the hematopoietic system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Food Science & Technology
Theerawat Dobutr, Wirapong Kantamala, Suphaporn Phimwapi, Nisachon Jangpromma, Patcharaporn Tippayawat, Sophon Boonlue, Jureerut Daduang, Sompong Klaynongsruang, Saowanee Poopornchai, Sakda Daduang
Summary: This study investigated the immunomodulatory effect of edible bird's nest (EBN) in vitro and in vivo studies. The results showed that EBN specifically enhanced the expansion of CD3(+) T-cells and restored lymphocyte subpopulations under immunosuppressive drug influence. EBN treatments also increased the number of peripheral blood T-cells in rats and affected the numbers of lymphoid cells in specific areas. The elevation of serum interleukin-2 (IL-2) was correlated with T-cell proliferation. These findings are important for developing therapeutic strategies to improve immunity and T-cell homeostasis under immunosuppressive therapy.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Ishara M. Isham, Mohamed S. H. Hassan, Reham M. Abd-Elsalam, Hiruni A. Ranaweera, Motamed E. Mahmoud, Shahnas M. Najimudeen, Awais Ghaffar, Susan C. Cork, Ashish Gupta, Mohamed Faizal Abdul-Careem
Summary: Infectious bronchitis virus (IBV) causes infectious bronchitis disease in chickens. The presence of maternal antibodies in chicks may provide some degree of protection against IBV infection in lymphoid organs such as the bursa of Fabricius and cecal tonsils. This study evaluated the impact of maternal antibodies on IBV infection in primary and secondary lymphoid organs, showing that the antibody titer was significantly higher in challenged groups and the IBV genome load and histopathological lesion scores were significantly lower in the vaccinated challenged group.
Article
Oncology
Miao He, Qihua He, Xiuyu Cai, Jun Liu, Hongshen Deng, Feng Li, Ran Zhong, Yi Lu, Haoxin Peng, Xiangrong Wu, Zisheng Chen, Shen Lao, Caichen Li, Jianfu Li, Jianxing He, Wenhua Liang
Summary: The study found that tumor-draining lymph nodes (TDLN) may influence the maturation of intratumoral tertiary lymphoid structures (TLS) in non-small cell lung cancer (NSCLC). Further research revealed the role of memory B cells and interferon (IFN)-gamma signaling in TLS formation in TDLN and primary tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Kevin T. Lynch, Samuel J. Young, Max O. Meneveau, Nolan A. Wages, Victor H. Engelhard, Craig L. Slingluff, Ileana S. Mauldin
Summary: The presence of TLS in cutaneous melanoma metastases is associated with increased intratumoral lymphocyte infiltration and improved overall survival in patients. Different types of TLS have varying effects on patient survival, indicating potential regulatory or antigen-driven immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Alec J. Wishnie, Tzippora Chwat-Edelstein, Mary Attaway, Bao Q. Vuong
Summary: Recent studies demonstrate that the affinity of the B cell receptor plays a key role in modulating T-B interactions and the subsequent differentiation of B cells in the extrafollicular and germinal center response. B cells expressing high affinity BCRs preferentially differentiate into antibody-secreting cells, while those expressing low affinity BCRs undergo further affinity maturation or differentiate into memory B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Irina Ushach, Ren Zhu, Elen Rosler, Rajendra K. Pandey, N. Tilani S. De Costa, Soheil Pourshahian, Qinglin Han, Chris Li, Leonid Beigelman, Sergei M. Gryaznov, Theodore Yun
Summary: The study aimed to design a novel immunomodulator to subvert immune tolerance to HBV, showing promising results in inducing strong immune responses against the virus by targeting CpG oligonucleotide to lymphoid organs in a mouse model of chronic HBV infection.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Immunology
Angelina De Martin, Yves Stanossek, Natalia Barbara Pikor, Burkhard Ludewig
Summary: This article discusses the biology of fibroblastic reticular cells (FRCs) in lymphoid organs and their role in activating or attenuating immune responses. FRCs provide structural support in secondary lymphoid organs and guide immune cells to specialized microenvironments. Adverse reprogramming of FRCs can lead to immunopathological tissue damage during infection and autoimmune conditions, as well as subvert antitumor immune responses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Rheumatology
Yanmei Li, Zhiqin Wang, Feng Han, Mei Zhang, Tong Yang, Ming Chen, Jun Du, Yin Wang, Li Zhu, Hou Hou, Yanxia Chang, Lin Han, Xing Lyu, Na Zhang, Wenwen Sun, Zhigang Cai, Wei Wei
Summary: The aim of this study was to analyze the transcriptional profiles of affected tissues and peripheral blood mononuclear cells (PBMCs) in IgG4-related disease (IgG4-RD) at the single-cell level. The study identified novel subsets of tissue-resident immune cells and revealed altered cellular communication patterns in IgG4-RD. These findings provide insights into the etiology and potential therapeutic targets of this autoimmune disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Laurence S. C. Lok, Menna R. Clatworthy
Summary: Neutrophils are not only short-lived innate immune cells that respond rapidly to inflammation and infections, but they also play a role in influencing adaptive immunity. By interacting with various immune cells in lymph nodes, neutrophils can impact antigen presentation and B-cell antibody responses. Understanding the mechanisms behind neutrophil interactions in lymph nodes could lead to the development of targeted therapies for inflammatory diseases.
