期刊
CARBOHYDRATE POLYMERS
卷 215, 期 -, 页码 226-234出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.03.085
关键词
Antibacterial; Chitosan-MoS2; Functionalization; Nanocomposite
资金
- National Natural Science Foundation of China [31871881]
- Jiangsu Agriculture Science and Technology Innovation Fund (JASTIF) [CX(18) 2025]
- SAMP
- T Support Program of Jiangsu Province [BE2017623]
- National First-class Discipline Program of Food Science and Technology [JUFSTR20180303, JUSRP51714B]
- Distinguished Professor Program of Jiangsu Province
Bacterial infections have evolved as a life-threatening problem afflicting people due to the abuse of antibiotics and emergence of drug-resistant bacteria. Thus developing novel antibacterial materials is an urgent need. Herein, chitosan-MoS2 (CS-MoS2) nanocomposite was synthesized through thiol ligand functionalization and chemical modification to achieve more efficient bactericidal activity. CS-MoS2 exhibited synergistic remarkable bactericidal capability against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli), where bacterial viabilities were significantly reduced. After treatment with 10 mu g/mL of CS-MoS2, 100% and 98.1% of S. aureus and E. coli cells were killed respectively. A mechanism study revealed that the positively charged CS-MoS2 could interact with cell membrane, then cause damage to the membrane and cellular constituents by generation of reactive oxygen species (ROS) and glutathione (GSH) oxidation, finally inhibit bacterial growth. The CS-MoS2 could be an attractive antibacterial agent with improved efficiency and provide more strategies for application of MoS2.
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