期刊
CARBOHYDRATE POLYMERS
卷 208, 期 -, 页码 451-456出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.12.096
关键词
Lactose-modified chitosan; Non-linear rheology; Strain-hardening; Active network; Boric acid
资金
- University of Trieste [FRADONATI2016-17]
- INTERREG V-A ITALIA-SLOVENIA 2014-2020 BANDO 1/2016 ASSE 1 [BioApp1472551605]
- ERA-MarineBiotech project Mar3Bio
Developing synthetic materials able to mimic micro- and macrorheological properties of natural networks opens up to novel applications and concepts in materials science. The present contribution describes an active network based on a semi-synthetic polymer, a lactitol-bearing chitosan derivative (Chitlac), and a transient inorganic cross-linker, boric acid. Due to the many and diverse anchoring points for boric acid on the flanking groups of Chitlac, the cross-links constantly break and reform in a highly dynamic fashion. The consequence is a network with unusual non-equilibrium and mechanical properties closely resembling the rheological behavior of natural three-dimensional arrangements and of cytoskeleton. Concepts like network nucleation, reorganization and disassembly are declined in terms of amount of the cross-linker, which acts as a putative motor for remodeling of the network upon application of energy. The out-of-equilibrium and non-linear behavior render the semi-synthetic system of great interest for tissue engineering and for developing in-vitro mimics of natural active matrices.
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