Article
Energy & Fuels
Arumugam Ramesh, Pamula Balaji Bhargav, Minh-Tri Nguyen-Le
Summary: Magnesium-alumina (Mg-Al2O3) composite was synthesized by sol-gel method and supported with SO42- catalyst using different methods. The catalyst prepared by hydrothermal method showed high acid sites. Sulfidation of catalysts played a significant role in the catalytic conversion of jojoba oil, with SO42-/Mg-Al2O3 (10) catalyst achieving 99% conversion efficiency under optimized conditions.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Article
Materials Science, Paper & Wood
Sauel Llacer Navarro, Monika Tolgo, Lisbeth Olsson, Tiina Nypelo
Summary: This study demonstrates the direct surface modification of cellulose nanocrystals (CNCs) using lytic polysaccharide monooxygenases (LPMOs) from the auxiliary activity 9 (AA9) family, revealing that sulfate ester groups on CNCs limit enzyme adsorption and modulate enzyme-mediated cuts on the surface, enabling carboxylation of the insoluble substrate. The importance of analyzing both solid and soluble reaction products is highlighted for understanding the oxidation mechanism.
Article
Chemistry, Applied
Jianfen Ye, Xiao Hua, Xiaomei Lyu, Wei Zhao, Wenbin Zhang, Ruijin Yang
Summary: A neutral polysaccharide (NPP) was extracted from peanut sediment, purified, and found to have a specific polysaccharide structure and chain conformation. Aggregates formed in the polysaccharide solution, but could be eliminated through specific treatments.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Abul Hossain, Deepika Dave, Fereidoon Shahidi
Summary: Sea cucumbers contain sulfated polysaccharides (SPs) with diverse pharmacological effects, including anticoagulant, anti-inflammatory, and anticancer activities. The effects of SPs depend on their structural characteristics, such as the degree of sulfation, position, molecular weight, and distribution of branches. However, these effects are also influenced by the species, origin, harvesting season, and extraction methods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Maxim S. Kokoulin, Alexandra S. Kuzmich, Lyudmila A. Romanenko, Irina V. Chikalovets
Summary: This study investigates the structure and antiproliferative effect of the capsular polysaccharide from Kangiella japonica KMM 3897 on cancer cells. The carbohydrate polymer was isolated, purified, and its structure was determined through chemical analysis and NMR spectroscopy.
CARBOHYDRATE POLYMERS
(2022)
Article
Acoustics
Haisong Wang, Jinran Chen, Pengfei Ren, Yiwen Zhang, Stanley Omondi Onayango
Summary: The study found that ultrasound irradiation significantly reduced the molecular weight and particle size of yellow tea polysaccharides. Partial degradation of yellow tea polysaccharides occurred during ultrasound treatment, but the monosaccharide composition remained unchanged. Irradiation enhanced the free radical scavenging activity of yellow tea polysaccharides.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Food Science & Technology
Junwen Cheng, Jiling Song, Yanbin Wang, Hailong Wei, Liang He, Yu Liu, Hongmei Ding, Qingrong Huang, Chuanjiu Hu, Xubo Huang, Yihan Jiang, Youliang Wu
Summary: A novel water-soluble mannogalactan (SSPS1) was obtained from the fruiting bodies of the Sanghuangporus sanghuang. It showed potent anticancer activity on HepG2 cells by inducing apoptosis through a mitochondria-mediated signaling pathway.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Shen Song, Xiaoyuan Liu, Ling Ding, Mohamed Aamer Abubaker, Ji Zhang, Yulong Huang, Shengrong Yang, Zengjie Fan
Summary: The study prepared a water-soluble bacterial cellulose sulfate using sulfur trioxide pyridine complex and bacterial cellulose, which exhibited shear thinning behavior and temperature-sensitive weak elastic gel characteristics based on rheological properties. The modified bacterial cellulose existed in linear polymer form in aqueous solution and could potentially be used as a renewable material in the field of biological tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Xubo Huang, Yalan Zhang, Na Xie, Junwen Cheng, Yanbin Wang, Shaofei Yuan, Qin Li, Rui Shi, Liang He, Min Chen
Summary: A polysaccharide (PBSR1) extracted from the processing waste of Phyllostachys pracecox bamboo shoots was found to be a triple-helix galactan with excellent thermal stability and antioxidant properties, as well as immunostimulatory effects.
Article
Food Science & Technology
Peilin Chen, Lu Liu, Zirun Cheng, Yi Zhang, Baodong Zheng, Xiaoke Hu, Hongliang Zeng
Summary: This study investigated the structure and fermentation properties of a polysaccharide fraction isolated from red marine alga Porphyra haitanensis in rat fecal microbiota. The results showed that this polysaccharide fraction could modulate the composition of rat fecal microflora, promote the growth of specific bacterial groups, and potentially regulate cholesterol metabolism. These findings are important for exploring the potential of algal polysaccharides in functional foods.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Food Science & Technology
Rui Han, Yongxuan Ma, Jianbo Xiao, Lijun You, Sandra Pedisic, Lan Liao
Summary: The study found that sulfated polysaccharide from Gracilaria Lemaneiformis could alleviate DSS-induced colitis by reducing inflammation, enhancing intestinal barrier, activating short chain fatty acid receptors, and regulating gut microbiota.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Physical
Rui Qi, Baohua Liu, Hongmei Li, Jian Wang, Xiaohong Li, Yong Jin, Songzhi Xie
Summary: In this study, diblock copolymers were synthesized to control the shape of nanomicelles by adjusting the pH values and lengths of the core-forming blocks. Ultrathin scarf-like micelles, ultrathin disk-like micelles, and spherical micelles were obtained, providing an effective method for fabricating well-defined nanostructures.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Oncology
James D. Hampton, Erica J. Peterson, Samantha J. Katner, Tia H. Turner, Mohammad A. Alzubi, J. Chuck Harrell, Mikhail G. Dozmorov, Joseph B. McGee Turner, Pam J. Gigliotti, Vita Kraskauskiene, Mayuri Shende, Michael O. Idowu, Madhavi Puchalapalli, Bin Hu, Larisa Litovchick, Eriko Katsuta, Kazuaki Takabe, Nicholas P. Farrell, Jennifer E. Koblinski
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer without targetable biomarkers. This study found that sGAG levels can predict the sensitivity of TNBC to Triplatin, a platinum agent. Triplatin showed significant antitumor efficacy in TNBC models with high levels of sGAGs, even in carboplatin-resistant tumors. Improved neoadjuvant and adjuvant treatments may enhance the clinical outcome of TNBC.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yuhei Takata, Masashi Kijima
Summary: Thermoplastic curdlan esters (CrdE(HepGlu)) with a carboxylic acid side chain were successfully prepared by reacting curdlan with glutaric anhydride and heptanoyl chloride. The esterification of curdlan effectively enhanced its formability and solubility in organic solvents. The mechanical properties and thermal stability of CrdE(HepGlu) films could be regulated by controlling the degree of substitution of the glutaric acid monoester moiety (DSGlu).
CARBOHYDRATE RESEARCH
(2023)
Article
Biochemical Research Methods
Katharina Lemmnitzer, Sebastian Kohling, Joanna Freyse, Jorg Rademann, Juergen Schiller
Summary: Glycosaminoglycans (GAG) are major components of the extracellular matrix, with sulfation playing a key role in mediating their binding with mediators. Natural sources of GAG are heterogeneous in terms of sulfation patterns and molecular weight, leading to contamination risks, which has sparked interest in careful characterization and synthetic alternatives. Structural characterization of sulfated GAG analogues is challenging due to sulfate loss during ionization, with optimized conditions enabling the gentle and fast mass spectrometry characterization of (fully) sulfated, artificial GAG-like oligosaccharides with minimized sulfate loss.
JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Chemistry, Applied
Yongtao Yang, Xiaojuan Xu, Qiang Wang
Summary: The study evaluated the effects of potassium sulfate (K2SO4) on the properties of different rice starches, showing that increasing K2SO4 concentration led to higher gelatinization temperatures and lower swelling capacities, resulting in decreased pasting viscosities. Waxy rice starch (WRS) exhibited the most significant changes in response to K2SO4.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Bingchao Duan, Siwei Zou, Ying Sun, Xiaojuan Xu
Summary: In this study, nucleic acid aptamers were attached to the polydeoxyadenylic acid (poly(dA)) tail to enhance tumor-targeting and cellular internalization. The results showed improved cellular uptake of s-LNT/poly(dA) composites in cancer cells, as well as increased internalization of LNT-FITC in cancer cells after aptamer conjugation. In vivo experiments confirmed enhanced accumulation of the composites at the tumor site. This work provides a novel strategy for utilizing triplex beta-glucan as delivery vectors with active tumor-targeting capabilities.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Environmental
Liqin Cai, Daofa Ying, Xichao Liang, Mengxiang Zhu, Xinghuan Lin, Qi Xu, Zongwei Cai, Xiaojuan Xu, Lina Zhang
Summary: A novel cationic polyelectrolyte microsphere (CCQM) with superior adsorption capabilities for anionic dyes and heavy metal ions was successfully synthesized. CCQM showed ultrafast adsorption rate and ultra-efficient adsorption capacity, surpassing most reported absorbents. Its adsorption mechanism involved cation exchange, chelating effect, proton exchange, complex formation, electrostatic interaction, and hydrogen bonding. Additionally, CCQM exhibited excellent recyclability, antibacterial viability, and biodegradability, making it a promising candidate for wastewater treatment applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Yan Meng, Hui Zhang, Na Hu, Baohui Zhang, Zhenpeng Qiu, Junjie Hu, Guohua Zheng, Lina Zhang, Xiaojuan Xu
Summary: Size controllable silver nanoparticles were synthesized in situ on polysaccharides-based nanotubes extracted from black fungus. The composites showed good antibacterial activity and stability, indicating their potential application in the biomedical field.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Liqin Cai, Shujun Zhou, Yanfeng Wang, Xiaojuan Xu, Lina Zhang, Zongwei Cai
Summary: This study comprehensively investigated the anti-tumor effects and mechanisms of black fungus polysaccharide, revealing its ability to inhibit proliferation of hepatoma carcinoma cells by promoting DNA damage, attenuating DNA damage repair, and inhibiting DNA synthesis, providing new insights for pharmacological research and clinical practice of polysaccharides in anti-tumor activities.
CARBOHYDRATE POLYMERS
(2021)
Review
Polymer Science
Huanhuan Chen, Ningyue Liu, Fangzhou He, Qingye Liu, Xiaojuan Xu
Summary: This review article focuses on the research progress of β-glucans extracted from different fungi, with a particular emphasis on the structure, conformational characteristics, and biological activities of β-glucans from Auricularia auricula judae, Lentinus edodes, and yeast. Additionally, the potential therapeutic applications of β-glucan-derived nanocomposite biomaterials are addressed.
Article
Materials Science, Biomaterials
Xiaojun Li, Yue Cheng, Jianfeng Zhang, Yarui Hou, Xiaojuan Xu, Qingye Liu
Summary: A novel strategy for fabricating bilayer hydrogel actuators based on the asymmetric distribution of crystalline regions was proposed, resulting in improved sensitivity to stimuli. The actuation behaviors are strongly dependent on experimental parameters such as pH, PVA content, and chemical-crosslinking density. Programmable 3D shape transformations can be achieved using designed 2D geometric patterns in the bilayer hydrogel, allowing for successful capture and transportation of cargo.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Food Science & Technology
Yujun Wan, Xiaojuan Xu, Robert G. Gilbert, Mitchell A. Sullivan
Summary: This review aims to increase understanding of the structure and function relationships of beta-glucans in treating type 2 diabetes by examining their detailed structural characteristics and anti-diabetic mechanisms, with the goal of expanding their applications.
Article
Chemistry, Applied
Huanhuan Chen, Ying Sun, Xiaojuan Xu, Qifa Ye
Summary: This study investigated the use of yeast-derived beta-(1, 3)-glucans to fabricate nanoparticles for the targeted delivery of methotrexate in the treatment of rheumatoid arthritis. The nanoparticles showed good biocompatibility and were effectively internalized by macrophages, leading to the reduction of pro-inflammatory factors in inflamed tissues. This work provides a safe alternative strategy for the clinical treatment of rheumatoid arthritis using beta-glucan nanoparticles as carriers.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Shihao Hu, Junqiao Wang, Shaoping Nie, Qiang Wang, Xiaojuan Xu
Summary: In this study, it was demonstrated that apple pectin and tomato pectin are high-ester and low-ester polysaccharides, respectively, with different properties under different conditions. The pectic polysaccharides showed semi-rigid chain conformations in NaNO3 aqueous solution and higher stiffness in water due to electrostatic repulsion. Under shear, the pectic polysaccharides exhibited shear-thickening behavior, which was stronger for those with longer side chains and higher molecular weight.
Article
Engineering, Environmental
Liqin Cai, Lina Zhang, Xiaojuan Xu
Summary: This study presents a stable and reusable homogeneous catalyst of ultra-small silver nanoparticles loaded triple-helix beta-glucan nanomaterial for efficient degradation of dyes and 4-nitrophenol in wastewater. The catalyst effectively disperses and stabilizes silver nanoparticles using Ag-O bonds in water, showing high catalytic efficiency. The research provides a novel strategy for designing eco-friendly homogeneous catalysts in wastewater treatment and expands the application of natural polysaccharides in synthetic catalysis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Kun Chen, Liqin Cai, Shixi Yang, Shuang Peng, Jinguo Huang, Jinglei Xu, Ziang Lu, Xiaojuan Xu, Boshi Fu, Lina Zhang, Xiang Zhou
Summary: The study developed a prodrug delivery system based on beta-(1 -> 3)-D-glucan modified with cisplatin, showing high anticancer activity and low toxicity. This system utilizes nanomaterials loaded with platinum prodrugs to effectively target and release in tumors, demonstrating significant antitumor properties in vitro and in vivo.
ACS APPLIED BIO MATERIALS
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
