期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 166, 期 4, 页码 535-540出版社
SPRINGER
DOI: 10.1007/s10517-019-04388-1
关键词
multipotent mesenchymal stromal cells; umbilical cord; bone marrow; secretome
Production of cytokines and growth factors by cultured human umbilical cord tissue- and bone marrow-derived multipotent mesenchymal stromal cells was measured by multiplex analysis. In most cases, the concentrations of bioactive factors in the culture medium conditioned by umbilical cord-derived cells was ten- to hundred-times higher than in the medium conditioned by bone marrow-derived cells. These results suggest that both multipotent mesenchymal stromal cells from the umbilical cord and cell-free products can have more pronounced therapeutic effect in comparison with mesenchymal stromal cells obtained from adult sources.
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