期刊
BIOLOGICAL CHEMISTRY
卷 396, 期 6-7, 页码 693-705出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2014-0310
关键词
acyl chain length; ceramide synthase; disease; sphingolipid
资金
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2013K2A1A2053119, NRF-2013R1A1A1057912, NRF-2013R1A1A1076013]
- National Research Foundation of Korea [2013R1A1A1076013, 2013R1A1A1057912] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Sphingolipids have emerged as an important lipid mediator in intracellular signalling and metabolism. Ceramide, which is central to sphingolipid metabolism, is generated either via a de novo pathway, by attaching fatty acyl CoA to a long-chain base, or via a salvage pathway, by degrading pre-existing sphingolipids. As a 'sphingolipid rheostat' has been proposed, the balance between ceramide and sphingosine-1-phosphate has been the object of considerable attention. Ceramide has recently been reported to have a different function depending on its acyl chain length: six ceramide synthases (CerS) determine the specific ceramide acyl chain length in mammals. All CerS-deficient mice generated to date show that sphingolipids with defined acyl chain lengths play distinct pathophysiological roles in disease models. This review describes recent advances in understanding the associations of CerS with various diseases and includes clinical case reports.
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