Article
Immunology
Jong Hee Choi, Jinhee Oh, Min Jung Lee, Seong-Gyu Ko, Seung-Yeol Nah, Ik-Hyun Cho
Summary: The study revealed that Gintonin has neuroprotective effects in models of multiple sclerosis, alleviating inflammatory lesions. The mechanism of action may involve inhibiting various signaling pathways, enhancing antioxidant activity, and modulating immune cell activity through LPARs, providing a new therapeutic approach for autoimmune disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Pharmacology & Pharmacy
Samar M. Shawki, Mohammed A. Saad, Rania M. Rahmo, Walaa Wadie, Hanan S. El-Abhar
Summary: Liraglutide shows neuroprotective potential in a rat model of Huntington's disease by modulating multiple molecular signaling pathways and reducing apoptosis and oxidative stress, demonstrating a neurotherapeutic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
May Nasser Bin-Jumah, Sadaf Jamal Gilani, Abdulaziz F. Alabbasi, Fahad A. Al-Abbasi, Shareefa A. AlGhamdi, Ohoud Y. Alshehri, Amira M. Alghamdi, Nadeem Sayyed, Imran Kazmi
Summary: The study demonstrates that fustin has neuroprotective effects by restoring memory function through modulation of behavioral activities, effectively reversing HD symptoms induced by 3-NPA via inhibiting oxidative and enzymatic activity.
Article
Pharmacology & Pharmacy
Pei Teng Lum, Mahendran Sekar, Lay Jing Seow, Mohd Farooq Shaikh, Alina Arulsamy, Thaarvena Retinasamy, Siew Hua Gan, Charles Gnanaraj, Norhaizan Mohd Esa, Gobinath Ramachawolran, Vetriselvan Subramaniyan, Suresh V. Chinni, Yuan Seng Wu
Summary: Huntington's disease (HD) is a neurodegenerative disease that affects the daily performances and life quality of patients. Mangiferin, a compound found in the Mangifera indica plant, has been proven to have medicinal benefits against memory and cognitive impairment in neurodegenerative diseases. This study aims to evaluate the neuroprotective effect of mangiferin against 3-nitropropionic acid (3NP) induced HD in rat models.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wael A. Mahdi, Shareefa A. AlGhamdi, Amira M. Alghamdi, Syed Sarim Imam, Sultan Alshehri, Mohammad A. Almaniea, Baraa Mohammed Hajjar, Fahad A. Al-Abbasi, Nadeem Sayyed, Imran Kazmi
Summary: This study aimed to analyze the neuroprotective effect of hibiscetin on rats with 3-nitropropionic acid-induced Huntington's disease. The results suggest that hibiscetin successfully restored the body weight and improved several biochemical and neuroinflammatory parameters in the rats.
Article
Biochemistry & Molecular Biology
Ahmad Fotoohi, Mohammad Raman Moloudi, Saed Hosseini, Kambiz Hassanzadeh, Marco Feligioni, Esmael Izadpanah
Summary: The study revealed that safranal effectively alleviated the motor dysfunction induced by 3-NP in rat model of Huntington's disease, showing potential as a therapeutic agent due to its modulating effect on oxidants-antioxidant balance.
NEUROCHEMICAL RESEARCH
(2021)
Article
Cell Biology
Kuan-Hung Lin, Jui-Chung Chiang, Wei-Min Chen, Ya-Hsuan Ho, Chao-Ling Yao, Hsinyu Lee
Summary: The balance between LPA receptor subtypes, regulated by GATA factors, plays a critical role in lineage commitment of myeloid progenitors. Manipulation of GATA factors affects the expression levels of LPA(2) and LPA3, indicating a novel mechanism regulating erythropoiesis and megakaryopoiesis. The physical interaction between GATA factors and the promoter region of LPAR genes further supports this regulatory role.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Plant Sciences
Jong Hee Choi, Tae Woo Kwon, Hyo Sung Jo, Yujeong Ha, Ik-Hyun Cho
Summary: This study investigated the therapeutic potential of Gintonin (GT), derived from Panax ginseng, in treating epilepsy. Results showed that GT alleviated seizures in mice and ameliorated excitotoxic events in the hippocampus by reducing neuroglial activation, proinflammatory cytokine expression, and increasing antioxidant activity. GT has the potential to be a treatment for epilepsy.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Medicine, Research & Experimental
Marwa El-Sayed El-Shamarka, Ayman E. El-Sahar, Muhammed A. Saad, Naglaa Assaf, Rabab H. Sayed
Summary: Inosine attenuated 3-NP-induced HD-like symptoms in rats by activating the A2AR/BDNF/TrKB/ERK/CREB signaling pathway.
Article
Pharmacology & Pharmacy
Priya Sharma, Manish Kumar, Nitin Bansal
Summary: The study demonstrates that ellagic acid pre-treatment protects rats from cognitive impairment and motor disturbances induced by 3-NP, largely by inhibiting oxido-nitrosative stress and promoting mitochondrial function. These findings suggest that EA supplementation may have protective potential against symptoms of Huntington's disease.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Immunology
Weam W. IbrahimnAff, Nora O. Abdel RasheednAff
Summary: The study explored the neuroprotective effects of diapocynin, a specific NADPH oxidase inhibitor, against the 3-nitropropionic acid (3-NP) model of Huntington's disease (HD) in rats. The results showed that diapocynin attenuated oxidative stress, neuroinflammation, glial activation, and apoptosis induced by 3-NP. Diapocynin also improved motor functions and histopathological derangements associated with HD. The findings suggest that diapocynin could be a promising candidate for the management of HD.
INFLAMMOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Pradeep Singh, Garima Mishra, Mulugeta Molla, Yohannes Shumet Yimer, Woretaw Sisay, Yared Andargie, Amien Ewunetie
Summary: Huntington's disease is a neurodegenerative disease that poses a major threat to the elderly population. It is caused by the expansion of repeats, triggering the formation of a mutant huntingtin protein that leads to neuronal death. Herbal nutraceuticals, enriched with antioxidants, are believed to have significant effects on Huntington's disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Afzal, Nadeem Sayyed, Khalid Saad Alharbi, Sami Alzarea, Mohammed Salem Alshammari, Fadhel A. Alomar, Sattam Khulaif Alenezi, Anwarulabedin Mohsin Quazi, Abdulaziz Alzarea, Imran Kazmi
Summary: This study evaluates the anti-Huntington's effect of rosiridin against 3-NPA-induced HD-like effects in rats. Results show that rosiridin improves behavioral parameters, modulates biochemical parameters, and reduces neuroinflammation.
Article
Cell Biology
Ying Kai Chan, Sean K. Wang, Colin J. Chu, David A. Copland, Alexander J. Letizia, Helena Costa Verdera, Jessica J. Chiang, Meher Sethi, May K. Wang, William J. Neidermyer, Yingleong Chan, Elaine T. Lim, Amanda R. Graveline, Melinda Sanchez, Ryan F. Boyd, Thomas S. Vihtelic, Rolando Gian Carlo O. Inciong, Jared M. Slain, Priscilla J. Alphonse, Yunlu Xue, Lindsey R. Robinson-McCarthy, Jenny M. Tam, Maha H. Jabbar, Bhubanananda Sahu, Janelle F. Adeniran, Manish Muhuri, Phillip W. L. Tai, Jun Xie, Tyler B. Krause, Andyna Vernet, Matthew Pezone, Ru Xiao, Tina Liu, Wei Wang, Henry J. Kaplan, Guangping Gao, Andrew D. Dick, Federico Mingozzi, Maureen A. McCall, Constance L. Cepko, George M. Church
Summary: The study engineered AAV vectors by incorporating short DNA oligonucleotides to antagonize TLR9 activation, reducing innate immune responses and enhancing gene expression in clinically relevant animal models. The engineered vectors can avoid adverse reactions in some models, demonstrating a potential wider therapeutic window for AAV therapies.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Thamer H. Albekairi, Arzoo Kamra, Sudeep Bhardwaj, Sidharth Mehan, Aditi Giri, Manisha Suri, Abdulrahman Alshammari, Metab Alharbi, Abdullah F. Alasmari, Acharan S. Narula, Reni Kalfin
Summary: Huntington's disease (HD) is a genetic disorder characterized by gene mutation and neuronal loss. A study has shown that beta Boswellic acid (beta-BA), in combination with vitamin E, has neuroprotective effects and can improve behavioral impairments in HD. The treatment with beta-BA restored neurotransmitter levels and enzyme activity, suggesting its potential in preventing neurological diseases like HD.
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)