Article
Medicine, Research & Experimental
Liang He, Zhuoran Wang, Rui Zhou, Wei Xiong, Yuqiao Yang, Ning Song, Jinqiao Qian
Summary: Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality. Cardiac miR-146a is emerging as a potent regulator of myocardial function. Dexmedetomidine preconditioning provides cardioprotective effects, of which mechanisms related to miR-146a-3p targeting IRAK1 and TRAF6 through inhibition of NF-kappa B signaling pathway and ROS emission.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Zhongfei Zhang, Xiaoxiong Zou, Run Zhang, Yu Xie, Zhiming Feng, Feng Li, Jianbang Han, Haitao Sun, Qian Ouyang, Shiting Hua, Bingke Lv, Tian Hua, Zhizheng Liu, Yingqian Cai, Yuxi Zou, Yanping Tang, Xiaodan Jiang
Summary: The study showed that hUMSC-Exos can attenuate microglia-mediated neuroinflammation and improve neural deficits following ischemic stroke. MiR-146a-5p plays a crucial role in this process.
Review
Immunology
Mengxue Zhang, Yiqing Yin
Summary: Postoperative cognitive dysfunction (POCD) is a common clinical symptom after surgery, characterized by a decline in neurocognitive function. Neuroinflammation mediated by microglia is the key mechanism of POCD. Anesthetics are believed to be a major cause of POCD development, as they activate microglia and induce neuroinflammation. However, the role of anesthetics in POCD remains controversial. Anesthetics can have both anti-inflammatory and pro-inflammatory effects, suggesting their dual roles in the pathogenesis of POCD. This review discusses the mechanisms by which commonly used anesthetics regulate microglial activation through inflammatory signaling pathways, highlighting the anti-inflammatory properties of anesthetics and their potential to improve cognitive performance. The beneficial effects of anesthetics on POCD vary depending on dose, exposure time, and patients' characteristics, emphasizing the need for careful selection of anesthetics to minimize the incidence of POCD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yanli Li, Shilian Tan, Yuanying Shen, Le Guo
Summary: The primary pathophysiological alteration caused by inflammatory bowel disease (IBD) is prolonged, excessive inflammatory response to stimulation factors, which leads to intestinal mucosal lesions. This study found that miR-146a-5p negatively regulated the expression of inflammatory factors through targeted downregulation of IRAK1/TRAF6, thus negatively regulating the IL-1 beta-stimulated inflammatory response in human intestinal epithelial cells. Therefore, miR-146a-5p may act as an important diagnostic biomarker and treatment target of IBD.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Neurosciences
Lei Mao, Qingcui Zeng, Wenjie Su, Menglong Song, Jiacen Li, Min Xie
Summary: This study demonstrated that VSL#3 could inhibit neuronal apoptosis and reduce oxidative stress in POCD mice by upregulating the expression of miR-146a to block the BTG2/Bax axis. This mechanism contributes to the protective role of probiotics treatment against POCD.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ruifang Han, Juan Gao, Liming Wang, Peng Hao, Xi Chen, Yuchuan Wang, Zhixin Jiang, Li Jiang, Ting Wang, Lin Zhu, Xuan Li
Summary: MiR-146a plays a role in regulating corneal inflammation in dry eye disease and negatively regulates inflammation in human corneal epithelial cells through the IRAK1/TRAF6/NF-κB pathway. This study provides a potential therapeutic approach for the treatment of dry eye disease.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Peifeng Han, Keisuke Sunada-Nara, Nobuyuki Kawashima, Mayuko Fujii, Shihan Wang, Thoai Quoc Kieu, Ziniu Yu, Takashi Okiji
Summary: This study found that miR-146b-5p can suppress inflammation in human dental pulp cells stimulated by LPS, and its synthesis is controlled via the NF-κB/IL6/STAT3 signaling cascade. The study also found that miR-146b-5p down-regulates the expression of pro-inflammatory mediators by targeting TRAF6, IRAK1, and RELA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Tong Hua, Mei Yang, Honghao Song, Erliang Kong, Mengqiu Deng, Yongchang Li, Jian Li, Zhixiao Liu, Hailong Fu, Yue Wang, Hongbin Yuan
Summary: This study demonstrates that huc-MSCs-derived exosomes attenuated chronic inflammatory pain, possibly through the regulation of autophagy and pyroptosis by miR-146a-5p/TRAF6.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Zhi Chen, QinYue Lu, Xiang Cao, Kun Wang, YuHao Wang, Yanni Wu, Zhangping Yang
Summary: Lead exposure was found to promote apoptosis and inflammation in mouse and cow mammary tissue. The up-regulation of IRAK1 and its specific target miR-146a were identified in the high-throughput sequencing profile of mammary gland tissue. Additionally, circRNA-05280 was found to regulate apoptosis and inflammation in the mammary gland by binding miR-146a and releasing its expression on target gene IRAK1.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Neurosciences
Yinqiong Huang, Xiaoyun Lin, Xiahong Lin
Summary: This study investigated the effects of advanced glycation end products (AGEs) on microglial polarization and the role of miR-146a-5p in its regulation. It was found that AGEs upregulated the M1 phenotype and downregulated the M2 phenotype, which could be reversed by miR-146a overexpression. In addition, the expression of NLRP3 and NF-kappa B was also modulated by miR-146a. The RAGE or TLR-4/miR-146a/NLRP3/NF-kB pathway may be involved in the regulation of microglial polarization induced by AGEs.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Meng Zhou, Yuzhen Liu, Haoxiang Xu, Xu Chen, Nana Zheng, Zhimin Duan, Yiping Ge, Dongqing Li, Tong Lin, Rong Zeng, Qing Chen, Min Li
Summary: This study revealed the role of hsa-circ_0102678 in regulating inflammation induced by C. acnes biofilm in acne. The findings showed that hsa-circ_0102678 could bind to miR-146a and promote the expression of IRAK1 and TRAF6, thus promoting keratinocyte inflammation.
JOURNAL OF INNATE IMMUNITY
(2023)
Article
Oncology
Chuan-Peng Liu, Ming Zhong, Jun-Xia Sun, Jin He, Yong Gao, Fang-Xia Qin
Summary: miR-146a effectively improves depressive behaviors in depressed model mice by inhibiting microglial activation and neuroinflammatory factor expression.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Neurosciences
Jiangnan Wu, Yanjing Guo, Wei Li, Zihao Zhang, Xinlei Li, Qidi Zhang, Qihang Du, Xinhuan Niu, Xijiang Liu, Gongming Wang
Summary: This study found that exploratory laparotomy induced cognitive function decline in aged mice but not in young mice, accompanied by inflammatory activation of microglia in the hippocampus. Depletion of microglia using a CSF1R inhibitor protected aged mice from POCD. The downregulation of the immune checkpoint Mef2C in aged microglia contributed to microglial priming and neuroinflammation, leading to increased vulnerability to POCD in aged individuals.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Rheumatology
R. Kong, J. Gao, L. Ji, Y. Peng, J. Zhang, D. Zhao
Summary: This study demonstrates that iguratimod can ameliorate the progression of rheumatoid arthritis by regulating miR-146a-mediated IRAK1 expression and TRAF6/JNK1 pathway. The experimental results indicate that iguratimod can reduce cell proliferation, migration, invasion, and inflammatory cytokine expression in RA-FLS, while enhancing apoptosis.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Oncology
Jingyuan Hou, Qiaoting Deng, Xunwei Deng, Wei Zhong, Sudong Liu, Zhixiong Zhong
Summary: This study demonstrated that miR-146a-5p negatively regulates LPS-induced NF Kappa B activation and the NLRP3 inflammasome signaling pathway in HUVECs by modulating TRAF6 and IRAK1 expression, indicating its potential as a therapeutic target for atherosclerosis.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)