期刊
BIOLOGICAL CHEMISTRY
卷 396, 期 11, 页码 1215-1222出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2015-0172
关键词
autolysosomes; autophagosomes; autophagy; hepatitis C virus; innate immunity; unfolded protein response
资金
- National Institutes of Diabetes and Digestive and Kidney Diseases [DK094652, DK100257]
- National Cancer Institute [CA177337]
Autophagy is a catabolic process by which cells remove protein aggregates and damaged organelles for recycling. It can also be used by cells to remove intracellular microbial pathogens, including viruses, in a process known as xenophagy. However, many viruses have developed mechanisms to subvert this intracellular antiviral response and even use this pathway to support their own replications. Hepatitis C virus (HCV) is one such virus and is an important human pathogen that can cause severe liver diseases. Recent studies indicated that HCV could activate the autophagic pathway to support its replication. This review summarizes the current knowledge on the interplay between HCV and autophagy and how this interplay affects HCV replication and host innate immune responses.
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